- Measurement of six primary indicators of methionine metabolism and provision of the “methylation index”
- Amino acids and metabolites measured by Liquid Chromatography-Mass Spectrometry
- Requires a single, overnight fasting plasma sample
- Results specific, patient-friendly commentary provided
Normal metabolism of the essential amino acid methionine is critical for cellular Methylation of DNA, proteins and neurotransmitters. Also, the methionine transsulfuration pathway provides conditionally essential cysteine which is the rate-limiting amino acid in glutathione biosynthesis. Aberrant methionine metabolism can occur in both genders at any age and can be associated with numerous health consequences. The DDI Methylation Profile evaluates the plasma concentrations of methionine, cysteine and key intermediary amino acid metabolites and can appropriately guide nutritional support to improve/normalize methionine metabolism.
Normal methionine metabolism is absolutely critical for folate-dependent transmethylation and transsulfuration. Abnormal metabolism of methionine can be found in both genders at any age. It is usually associated with genetic or nutritional deficiencies, aging and exposures to environmental toxins (e.g. lead can impair Methylation via inhibition of the enzyme methyltetrahydrofolate reductase (MTHFR).
Conditions associated with untreated, aberrant methionine metabolism include, but are not limited to:
- abnormal neurotransmitter metabolism and psychiatric disorders such as schizophrenia and bipolar disorder;
- neurodegenerative diseases;
- dysregulation of nitric acid homeostasis;
- oxidative stress;
- global under-methylation/synthesis/repair of DNA;
- immune dysregulation (autoimmunity);
- cardiovascular disease;
- congenital heart disease/birth defects;
- impaired endogenous detoxification processes and
- increased risk for Down’s syndrome.
Methionine is first enzymatically converted to S-adenosylmethionine (SAM), the principal methyl donor for methylation of DNA, RNA, protein, phospholipids, creatinine and neurotransmitters. S-adenosylhomocysteine (SAH) is generated as a product of transmethylation and is hydrolyzed to homocysteine (Hcy) and adenosine through a reversible reaction. SAH is a potent inhibitor of methylation reactions. Efficient removal of adenosine and Hcy is imperative to prevent accumulation of SAH. Hcy is normally removed/recycled by remethylation to methionine through a series of reactions that require 5-methyltetrahydrofolate, B-12 and betaine to complete the normal methylation cycle. A low ration of SAM to SAH is a sensitive indicator of under-methylation. Elevated plasma Hcy is an independent risk factor for cardiovascular disease (CVD). Recent research suggests that elevated SAH may be an even better predictor of risk for CVD.
The methionine transsulfuration pathway occurs primarily in the liver and diverts Hcy away from remethylation to methionine towards synthesis of the conditionally essential amino acid cysteine. Homocysteine in the presence of serine and B-6 is enzymatically converted to cystathionine and ultimately cysteine. Cysteine is the rate limiting amino acid in the biosynthesis of quintessential glutathione (GSH). GSH is pivotal in the regulation of intracellular redox homeostasis, oxidative stress, immune function, DNA synthesis and repair, apoptosis and detoxification of metals and chemicals.
The Doctor's Data Methylation profile evaluates the plasma levels of methionine, cysteine, SAM, SAH, Hcy, and cystathionine and provides the important “methylation index” (ratio of SAM to SAH). The test results can appropriately guide nutritional support to improve/normalize methionine metabolism and meliorate or prevent the potential adverse consequences associated with inadequate methylation and transsulfuration capacity.
Results: Results can take up to 4 weeks to receive from the lab and are emailed by Dr. Lynch every Monday along with brief interpretations and suggestions. All test results are sent to us confidentially and are emailed to the individual who ordered it. If exceptions occur, we must be notified directly via email firstname.lastname@example.org.
|Product Name||Methylation Profile Test - Doctors Data|
|Return Policy||This test is pre-paid. You may request a full refund if the test kit has not been used.|
|Does not contain||Gluten, Dairy, Egg, Soy, Fish, Shellfish, Nuts, Corn, GMO, Prebiotics|
Find a health professional to order Methylation Testing for you:
Physician Directory at Seeking Health Educational InstituteWhich supplements should I discontinue using prior to taking this test? If you are interested in using this test to see how your methylation is working without supplementation, discontinue using supplements containing SAMe, NAC, Glutathione, B6, B12, TMG, and Folate for at least 24 hours prior to taking this test. If you would like to see the effects of your supplement regimen on your methylation pathways, you may choose to continue taking these supplements prior to taking this test. Dr Lynch recommends taking this test without supplementation as a baseline to see how your body is functioning on its own. Make changes based on the lab findings using lifestyle, diet and supplements for a couple months and then retest – again without supplementation. This will help determine whether these changes have had meaningful effects on your methylation.
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