Methylation Profile Test - Doctors Data

DOCDATA-METHYLP-TEST

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Quick Overview

Detoxing and do not feel well? Have the MTHFR mutation? Wonder why you are sensitive to chemicals? Ordering the Methylation Profile by Doctor's Data is a good idea as it helps determine where in your detoxification pathways you are stuck. Methylation is also critical for healthy neurotransmitter function. Those with mental disorders may benefit from the information provided by the Methylation Profile.

Insurance is NOT accepted for this test.

This test is not available to International customers (including Canadian customers).

New York/Ohio Residents : Sorry, this test is not available to residents in New York or Ohio. No priority, 2 day or overnight shipping available for this test kit. Please select standard Ground Shipping.

Results: Results can take up to 4 weeks to receive from the lab and are emailed by Dr. Lynch every Monday along with brief interpretations and suggestions. All test results are sent to us confidentially and are emailed to the individual who ordered it. If exceptions occur, we must be notified directly via email customer@seekinghealth.com.

Directions: For accurate results, fasting overnight is required. Discontinuing all supplementation is not needed. However, if you or your doctor are interested in determining how your methylation is working without supplements, discontinue taking the following supplements for at least 24 hours prior to taking this test:

  • SAMe
  • NAC
  • Glutathione
  • B6
  • B12
  • TMG
  • Folate

If you or your doctor are interesting in determining how your supplement regimen is affecting your methylation pathways, you may decide to continue supplementation prior to taking this test. Dr. Lynch recommends taking this test without supplementation as a baseline to see how your body is functioning on its own. Make changes based on the lab findings using lifestyle, diet and supplements for a couple months and then retest– again without supplementation.

For more detailed specimen collection instructions, see Methylation Profile Specimen Collection Instructions.

Product Description

The Methylation Profile Test is available only in the USA.

  • Measurement of six primary indicators of methionine metabolism and provision of the “methylation index”
  • Amino acids and metabolites measured by Liquid Chromatography-Mass Spectrometry
  • Requires a single, overnight fasting plasma sample
  • Results specific, patient-friendly commentary provided

Normal metabolism of the essential amino acid methionine is critical for cellular Methylation of DNA, proteins and neurotransmitters. Also, the methionine transsulfuration pathway provides conditionally essential cysteine which is the rate-limiting amino acid in glutathione biosynthesis. Aberrant methionine metabolism can occur in both genders at any age and can be associated with numerous health consequences. The DDI Methylation Profile evaluates the plasma concentrations of methionine, cysteine and key intermediary amino acid metabolites and can appropriately guide nutritional support to improve/normalize methionine metabolism.

Normal methionine metabolism is absolutely critical for folate-dependent transmethylation and transsulfuration. Abnormal metabolism of methionine can be found in both genders at any age. It is usually associated with genetic or nutritional deficiencies, aging and exposures to environmental toxins (e.g. lead can impair Methylation via inhibition of the enzyme methyltetrahydrofolate reductase (MTHFR).

Conditions associated with untreated, aberrant methionine metabolism include, but are not limited to:

  • abnormal neurotransmitter metabolism and psychiatric disorders such as schizophrenia and bipolar disorder;
  • neurodegenerative diseases;
  • autism;
  • dysregulation of nitric acid homeostasis;
  • oxidative stress;
  • global under-methylation/synthesis/repair of DNA;
  • immune dysregulation (autoimmunity);
  • cancer,
  • cardiovascular disease;
  • congenital heart disease/birth defects;
  • impaired endogenous detoxification processes and
  • increased risk for Down’s syndrome.

Methylation

Methionine is first enzymatically converted to S-adenosylmethionine (SAM), the principal methyl donor for methylation of DNA, RNA, protein, phospholipids, creatinine and neurotransmitters. S-adenosylhomocysteine (SAH) is generated as a product of transmethylation and is hydrolyzed to homocysteine (Hcy) and adenosine through a reversible reaction. SAH is a potent inhibitor of methylation reactions. Efficient removal of adenosine and Hcy is imperative to prevent accumulation of SAH. Hcy is normally removed/recycled by remethylation to methionine through a series of reactions that require 5-methyltetrahydrofolate, B-12 and betaine to complete the normal methylation cycle. A low ration of SAM to SAH is a sensitive indicator of under-methylation. Elevated plasma Hcy is an independent risk factor for cardiovascular disease (CVD). Recent research suggests that elevated SAH may be an even better predictor of risk for CVD.

Transsulfuration:   Methionine-Hcy-cysteine

The methionine transsulfuration pathway occurs primarily in the liver and diverts Hcy away from remethylation to methionine towards synthesis of the conditionally essential amino acid cysteine. Homocysteine in the presence of serine and B-6 is enzymatically converted to cystathionine and ultimately cysteine. Cysteine is the rate limiting amino acid in the biosynthesis of quintessential glutathione (GSH). GSH is pivotal in the regulation of intracellular redox homeostasis, oxidative stress, immune function, DNA synthesis and repair, apoptosis and detoxification of metals and chemicals.

The Doctor's Data Methylation profile evaluates the plasma levels of methionine, cysteine, SAM, SAH, Hcy, and cystathionine and provides the important “methylation index” (ratio of SAM to SAH). The test results can appropriately guide nutritional support to improve/normalize methionine metabolism and meliorate or prevent the potential adverse consequences associated with inadequate methylation and transsulfuration capacity.

Results: Results can take up to 4 weeks to receive from the lab and are emailed by Dr. Lynch every Monday along with brief interpretations and suggestions. All test results are sent to us confidentially and are emailed to the individual who ordered it. If exceptions occur, we must be notified directly via email customer@seekinghealth.com.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Additional Information

Product Name Methylation Profile Test - Doctors Data
Brand Doctors Data
MPN DOCDATA-METHYLP-TEST
Return Policy This test is pre-paid. You may request a full refund if the test kit has not been used.
SKU DOCDATA-METHYLP-TEST
Does not contain Gluten, Dairy, Egg, Soy, Fish, Shellfish, Nuts, Corn, GMO, Prebiotics
Retail Price $195.00
Which supplements should I discontinue using prior to taking this test? If you are interested in using this test to see how your methylation is working without supplementation, discontinue using supplements containing SAMe, NAC, Glutathione, B6, B12, TMG, and Folate for at least 24 hours prior to taking this test. If you would like to see the effects of your supplement regimen on your methylation pathways, you may choose to continue taking these supplements prior to taking this test. Dr Lynch recommends taking this test without supplementation as a baseline to see how your body is functioning on its own. Make changes based on the lab findings using lifestyle, diet and supplements for a couple months and then retest – again without supplementation. This will help determine whether these changes have had meaningful effects on your methylation.


Product Questions

Questions on Methylation Profile Test - Doctors Data

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  • Eastern Europe6/24/14 7:35 PM
    • Would it be in any way possible to ship this test to Hungary?
    • Hello,

      This test is not available in Eastern Europe due to the shipping times/delays with customs.  The test needs to be returned to the lab within 48 hours of the blood draw.

      Thank you for your time,

      Michelle

    • Do you find this question helpful?  Yes   No
  • Methylation Profile Test - Doctors Data7/5/14 2:11 PM
    • I am c677t homoygous. Is this test done at home? One questioner said she had trouble finding a lab.
    • Hello,

      The Doctor's Data test does need to be completed at a lab, and must be sent overnight using the pre-paid shipping label included in the test kit. The blood draw can be done at a local lab, urgent care facility, or hospital. If you are having trouble finding a lab, please let us know. We are happy to assist.

      Thank you for your time,

      Sarissa

    • Do you find this question helpful?  Yes   No
  • Where to get blood draw7/6/14 12:24 AM
    • I am currently living in BC Canada but was born and raised in Washington state. I am wanting to have this test and I can have it shipped to Blaine Wa but need to know where would I have the blood drawn. I was hoping someplace in Bellingham that morning I pick it up. I am not sure how that works.

      Thank you!!!
    • Good morning,

      Thank you for contacting Seeking Health regarding the Doctors Data Methylation Profile Test.  This can be done at any lab in Bellingham, there is a lab at St. Joes Hospital near the birthing center or you can go to urgent care or an independent lab such as Lab Core or Quest Diagnostics.   If you are having issues locating a lab please let us know. 

      This test can be shipped to your Blaine address as soon as today if the order is placed by 11:30am.

      If we can be of further assistance pleas let us know.

      Thank you for your time,

      Michelle

    • Do you find this question helpful?  Yes   No
  • Methylation test7/6/14 12:26 AM
    • Hi

      I am sorry but I emailed you twice before looking at this more closely. I use Lab Corp and would like to get their price. What do I ask for? Is there a code?

      Also your link to a sample of the Dr.'s Report does not work. Can you send me a link that does?

      Many thanks. Will do this as soon as I hear from you.

      np
    • Hello,

      Thank you for your follow-up question about the Methylation Profile Test. If you would like a quote on the prices at Lab Corp, you would need to contact Lab Corp and inquire about the price of a plasma draw. The link to the sample is working on our system. If you could please let us know how you are accessing the site (i.e. phone or computer, web browser) we are happy to troubleshoot that for you.

      Thank you for your time.

      Sarissa

    • Do you find this question helpful?  Yes   No
  • Cynthia Schoenbauer8/16/14 6:12 AM
    • Hello, Does Dr. Lynch still evaluate each and every one of these tests? Thank you, Cynthia
    • Hello Cynthia,

      Thank you for contacting Seeking Health. Yes, Dr. Lynch evaluates all of the genetic tests purchased on SeekingHealth.com. Your results will be sent with his interpretation of the lab results as well as personalized recommendations for helpful supplements based on your results.

      Thank you for your time,

      Sarissa

    • Do you find this question helpful?  Yes   No
  • Pretesting instructions?9/17/14 3:46 PM
    • Hi

      I'm interested in ordering this test, do I need to discontinue any/all supplements I'm currently taking and if so, how long in advance? Specifically curious about the B complex I'm taking.
      In addition I'm also taking fish oil & Vitamin D3 (occasionally).

      Also, I'm getting some genetic testing done (23andme), which will include C677T & A1298C, would it be helpful to Dr Lynch to have those results available when interpreting this test?

      Thanks
      Peter
    • Hello Peter,

      Thank you for contacting Seeking Health regarding the Methylation Profile Test. An overnight fast is required for accurate test results. Discontinuing all supplementation is not needed; however certain supplements should be stopped in order to see how your methylation is working without supplementation.

      Discontinue the following for 24 hours:

      • SAMe
      • NAC
      • Glutathione
      • B6
      • B12
      • TMG
      • Folate

      This depends on whether your doctor is interested in determining how your methylation is working independent of supplementation or in determining the effectiveness of a supplement regimen. Some doctors want patients to continue supplementation prior to taking this test to see how the supplements are affecting methylation pathways.

      Dr. Lynch recommends taking this test without supplementation as a baseline to see how your body is functioning on its own. Then, he suggests making changes based on the lab findings using lifestyle, diet and supplements for a couple months and testing again – again without supplementation. This will allow both patient and doctor to see if making these changes has produced a meaningful change in methylation processes.

      At this time, Dr. Lynch is not doing personal consultations - you will receive his interpretation of those tests that are purchased through seekinghealth.com. We are not able to send your results from other tests to Dr. Lynch. Thank you for your time and understanding.

      Sarissa

    • Do you find this question helpful?  Yes   No

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