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Methylation Profile Test - Doctors Data

DOCDATA-METHYLP-TEST
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Quick Overview

Lab Testing is no longer available from Seeking Health.

To fully focus on our mission of providing education and products that can help optimize lives, we have found it necessary to discontinue our lab test kits.

However, this test kit can still be ordered directly from Doctor’s Data [phone: +1(630) 377-8139].

You can also order from many of our qualified practitioners on our Physician Directory at Seeking Health Educational Institute. Finding a doctor who can interpret these lab tests used to require an exhaustive search, but now it's just a click away, thanks to Dr. Lynch's resource of health professionals with training in the areas of MTHFR, methylation and nutrigenomics – and we are continuing to increase the number of doctors who know about these tests through conferences and education!

Product Description

Lab Testing is no longer available from Seeking Health.

To fully focus on our mission of providing education and products that can help optimize lives, we have found it necessary to discontinue our lab test kits.

However, this test kit can still be ordered directly from Doctor’s Data [phone: +1(630) 377-8139].

You can also order from many of our qualified practitioners on our Physician Directory at Seeking Health Educational Institute. Finding a doctor who can interpret these lab tests used to require an exhaustive search, but now it's just a click away, thanks to Dr. Lynch's resource of health professionals with training in the areas of MTHFR, methylation and nutrigenomics – and we are continuing to increase the number of doctors who know about these tests through conferences and education!

  • Measurement of six primary indicators of methionine metabolism and provision of the “methylation index”
  • Amino acids and metabolites measured by Liquid Chromatography-Mass Spectrometry
  • Requires a single, overnight fasting plasma sample
  • Results specific, patient-friendly commentary provided

Normal metabolism of the essential amino acid methionine is critical for cellular Methylation of DNA, proteins and neurotransmitters. Also, the methionine transsulfuration pathway provides conditionally essential cysteine which is the rate-limiting amino acid in glutathione biosynthesis. Aberrant methionine metabolism can occur in both genders at any age and can be associated with numerous health consequences. The DDI Methylation Profile evaluates the plasma concentrations of methionine, cysteine and key intermediary amino acid metabolites and can appropriately guide nutritional support to improve/normalize methionine metabolism.

Normal methionine metabolism is absolutely critical for folate-dependent transmethylation and transsulfuration. Abnormal metabolism of methionine can be found in both genders at any age. It is usually associated with genetic or nutritional deficiencies, aging and exposures to environmental toxins (e.g. lead can impair Methylation via inhibition of the enzyme methyltetrahydrofolate reductase (MTHFR).

Conditions associated with untreated, aberrant methionine metabolism include, but are not limited to:

  • abnormal neurotransmitter metabolism and psychiatric disorders such as schizophrenia and bipolar disorder;
  • neurodegenerative diseases;
  • autism;
  • dysregulation of nitric acid homeostasis;
  • oxidative stress;
  • global under-methylation/synthesis/repair of DNA;
  • immune dysregulation (autoimmunity);
  • cancer,
  • cardiovascular disease;
  • congenital heart disease/birth defects;
  • impaired endogenous detoxification processes and
  • increased risk for Down’s syndrome.

Methylation

Methionine is first enzymatically converted to S-adenosylmethionine (SAM), the principal methyl donor for methylation of DNA, RNA, protein, phospholipids, creatinine and neurotransmitters. S-adenosylhomocysteine (SAH) is generated as a product of transmethylation and is hydrolyzed to homocysteine (Hcy) and adenosine through a reversible reaction. SAH is a potent inhibitor of methylation reactions. Efficient removal of adenosine and Hcy is imperative to prevent accumulation of SAH. Hcy is normally removed/recycled by remethylation to methionine through a series of reactions that require 5-methyltetrahydrofolate, B-12 and betaine to complete the normal methylation cycle. A low ration of SAM to SAH is a sensitive indicator of under-methylation. Elevated plasma Hcy is an independent risk factor for cardiovascular disease (CVD). Recent research suggests that elevated SAH may be an even better predictor of risk for CVD.

Transsulfuration:   Methionine-Hcy-cysteine

The methionine transsulfuration pathway occurs primarily in the liver and diverts Hcy away from remethylation to methionine towards synthesis of the conditionally essential amino acid cysteine. Homocysteine in the presence of serine and B-6 is enzymatically converted to cystathionine and ultimately cysteine. Cysteine is the rate limiting amino acid in the biosynthesis of quintessential glutathione (GSH). GSH is pivotal in the regulation of intracellular redox homeostasis, oxidative stress, immune function, DNA synthesis and repair, apoptosis and detoxification of metals and chemicals.

The Doctor's Data Methylation profile evaluates the plasma levels of methionine, cysteine, SAM, SAH, Hcy, and cystathionine and provides the important “methylation index” (ratio of SAM to SAH). The test results can appropriately guide nutritional support to improve/normalize methionine metabolism and meliorate or prevent the potential adverse consequences associated with inadequate methylation and transsulfuration capacity.

Results: Results can take up to 4 weeks to receive from the lab and are emailed by Dr. Lynch every Monday along with brief interpretations and suggestions. All test results are sent to us confidentially and are emailed to the individual who ordered it. If exceptions occur, we must be notified directly via email customer@seekinghealth.com.

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Additional Information

Product Name Methylation Profile Test - Doctors Data
Brand Doctors Data
MPN DOCDATA-METHYLP-TEST
Return Policy This test is pre-paid. You may request a full refund if the test kit has not been used.
SKU DOCDATA-METHYLP-TEST
Does not contain Gluten, Dairy, Egg, Soy, Fish, Shellfish, Nuts, Corn, GMO, Prebiotics
Retail Price $225.00

Find a health professional to order Methylation Testing for you:

Physician Directory at Seeking Health Educational Institute

Which supplements should I discontinue using prior to taking this test? If you are interested in using this test to see how your methylation is working without supplementation, discontinue using supplements containing SAMe, NAC, Glutathione, B6, B12, TMG, and Folate for at least 24 hours prior to taking this test. If you would like to see the effects of your supplement regimen on your methylation pathways, you may choose to continue taking these supplements prior to taking this test. Dr Lynch recommends taking this test without supplementation as a baseline to see how your body is functioning on its own. Make changes based on the lab findings using lifestyle, diet and supplements for a couple months and then retest – again without supplementation. This will help determine whether these changes have had meaningful effects on your methylation.

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The information on this website is for informational and educational purposes only. It is not an attempt by the writers or publisher to diagnose or prescribe, nor should it be construed to be such. The information is not intended to replace medical advice offered by physicians. Readers are hereby encouraged to consult with a licensed health care professional concerning the information presented, which has been received from sources deemed reliable, but no guarantees, expressed or implied, can be made regarding the accuracy of same. Therefore, readers are also encouraged to verify for themselves and to their own satisfaction the accuracy of all reports, recommendations, conclusions, comments, opinions, or anything else published herein before making any kind of decisions based upon what they have read. If you have a medical condition, please consult your medical practitioner. Seeking Health, LLC will not be liable for any direct, indirect, consequential, special, exemplary, or other damages arising from the use or misuse of any products, materials or information published.

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