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Methylation Profile Test - Doctors Data


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Quick Overview

You may order directly from us if needed and Dr Lynch will provide some information back about the results.

Do understand that in no way is Dr Lynch diagnosing or treating you. He merely is helping interpret what the results mean in regards to methylation function.

Find a health professional to order Methylation Testing for you:

Physician Directory at Seeking Health Educational Institute

Product Description

We recommend finding a health professional to order Methylation Testing for you:

Physician Directory at Seeking Health Educational Institute

You may order directly from us if needed and Dr Lynch will provide some information back about the results.

Do understand that in no way is Dr Lynch diagnosing or treating you. He merely is helping interpret what the results mean in regards to methylation function.

The Methylation Profile Test is available only in the USA.

  • Measurement of six primary indicators of methionine metabolism and provision of the “methylation index”
  • Amino acids and metabolites measured by Liquid Chromatography-Mass Spectrometry
  • Requires a single, overnight fasting plasma sample
  • Results specific, patient-friendly commentary provided

Normal metabolism of the essential amino acid methionine is critical for cellular Methylation of DNA, proteins and neurotransmitters. Also, the methionine transsulfuration pathway provides conditionally essential cysteine which is the rate-limiting amino acid in glutathione biosynthesis. Aberrant methionine metabolism can occur in both genders at any age and can be associated with numerous health consequences. The DDI Methylation Profile evaluates the plasma concentrations of methionine, cysteine and key intermediary amino acid metabolites and can appropriately guide nutritional support to improve/normalize methionine metabolism.

Normal methionine metabolism is absolutely critical for folate-dependent transmethylation and transsulfuration. Abnormal metabolism of methionine can be found in both genders at any age. It is usually associated with genetic or nutritional deficiencies, aging and exposures to environmental toxins (e.g. lead can impair Methylation via inhibition of the enzyme methyltetrahydrofolate reductase (MTHFR).

Conditions associated with untreated, aberrant methionine metabolism include, but are not limited to:

  • abnormal neurotransmitter metabolism and psychiatric disorders such as schizophrenia and bipolar disorder;
  • neurodegenerative diseases;
  • autism;
  • dysregulation of nitric acid homeostasis;
  • oxidative stress;
  • global under-methylation/synthesis/repair of DNA;
  • immune dysregulation (autoimmunity);
  • cancer,
  • cardiovascular disease;
  • congenital heart disease/birth defects;
  • impaired endogenous detoxification processes and
  • increased risk for Down’s syndrome.


Methionine is first enzymatically converted to S-adenosylmethionine (SAM), the principal methyl donor for methylation of DNA, RNA, protein, phospholipids, creatinine and neurotransmitters. S-adenosylhomocysteine (SAH) is generated as a product of transmethylation and is hydrolyzed to homocysteine (Hcy) and adenosine through a reversible reaction. SAH is a potent inhibitor of methylation reactions. Efficient removal of adenosine and Hcy is imperative to prevent accumulation of SAH. Hcy is normally removed/recycled by remethylation to methionine through a series of reactions that require 5-methyltetrahydrofolate, B-12 and betaine to complete the normal methylation cycle. A low ration of SAM to SAH is a sensitive indicator of under-methylation. Elevated plasma Hcy is an independent risk factor for cardiovascular disease (CVD). Recent research suggests that elevated SAH may be an even better predictor of risk for CVD.

Transsulfuration:   Methionine-Hcy-cysteine

The methionine transsulfuration pathway occurs primarily in the liver and diverts Hcy away from remethylation to methionine towards synthesis of the conditionally essential amino acid cysteine. Homocysteine in the presence of serine and B-6 is enzymatically converted to cystathionine and ultimately cysteine. Cysteine is the rate limiting amino acid in the biosynthesis of quintessential glutathione (GSH). GSH is pivotal in the regulation of intracellular redox homeostasis, oxidative stress, immune function, DNA synthesis and repair, apoptosis and detoxification of metals and chemicals.

The Doctor's Data Methylation profile evaluates the plasma levels of methionine, cysteine, SAM, SAH, Hcy, and cystathionine and provides the important “methylation index” (ratio of SAM to SAH). The test results can appropriately guide nutritional support to improve/normalize methionine metabolism and meliorate or prevent the potential adverse consequences associated with inadequate methylation and transsulfuration capacity.

Results: Results can take up to 4 weeks to receive from the lab and are emailed by Dr. Lynch every Monday along with brief interpretations and suggestions. All test results are sent to us confidentially and are emailed to the individual who ordered it. If exceptions occur, we must be notified directly via email customer@seekinghealth.com.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Additional Information

Product Name Methylation Profile Test - Doctors Data
Brand Doctors Data
Return Policy This test is pre-paid. You may request a full refund if the test kit has not been used.
Does not contain Gluten, Dairy, Egg, Soy, Fish, Shellfish, Nuts, Corn, GMO, Prebiotics
Retail Price $225.00

Find a health professional to order Methylation Testing for you:

Physician Directory at Seeking Health Educational Institute

Which supplements should I discontinue using prior to taking this test? If you are interested in using this test to see how your methylation is working without supplementation, discontinue using supplements containing SAMe, NAC, Glutathione, B6, B12, TMG, and Folate for at least 24 hours prior to taking this test. If you would like to see the effects of your supplement regimen on your methylation pathways, you may choose to continue taking these supplements prior to taking this test. Dr Lynch recommends taking this test without supplementation as a baseline to see how your body is functioning on its own. Make changes based on the lab findings using lifestyle, diet and supplements for a couple months and then retest – again without supplementation. This will help determine whether these changes have had meaningful effects on your methylation.

Product Questions

Questions on Methylation Profile Test - Doctors Data

Sort by Descending
  • Eastern Europe6/24/14 7:35 PM
    • Would it be in any way possible to ship this test to Hungary?
    • Hello,

      This test is not available in Eastern Europe due to the shipping times/delays with customs.  The test needs to be returned to the lab within 48 hours of the blood draw.

      Thank you for your time,


    • Do you find this question helpful?  Yes   No
  • Methylation Profile Test - Doctors Data7/5/14 2:11 PM
    • I am c677t homoygous. Is this test done at home? One questioner said she had trouble finding a lab.
    • Hello,

      The Doctor's Data test does need to be completed at a lab, and must be sent overnight using the pre-paid shipping label included in the test kit. The blood draw can be done at a local lab, urgent care facility, or hospital. If you are having trouble finding a lab, please let us know. We are happy to assist.

      Thank you for your time,


    • Do you find this question helpful?  Yes   No
  • Where to get blood draw7/6/14 12:24 AM
    • I am currently living in BC Canada but was born and raised in Washington state. I am wanting to have this test and I can have it shipped to Blaine Wa but need to know where would I have the blood drawn. I was hoping someplace in Bellingham that morning I pick it up. I am not sure how that works.

      Thank you!!!
    • Good morning,

      Thank you for contacting Seeking Health regarding the Doctors Data Methylation Profile Test.  This can be done at any lab in Bellingham, there is a lab at St. Joes Hospital near the birthing center or you can go to urgent care or an independent lab such as Lab Core or Quest Diagnostics.   If you are having issues locating a lab please let us know. 

      This test can be shipped to your Blaine address as soon as today if the order is placed by 11:30am.

      If we can be of further assistance pleas let us know.

      Thank you for your time,


    • Do you find this question helpful?  Yes   No
  • Methylation test7/6/14 12:26 AM
    • Hi

      I am sorry but I emailed you twice before looking at this more closely. I use Lab Corp and would like to get their price. What do I ask for? Is there a code?

      Also your link to a sample of the Dr.'s Report does not work. Can you send me a link that does?

      Many thanks. Will do this as soon as I hear from you.

    • Hello,

      Thank you for your follow-up question about the Methylation Profile Test. If you would like a quote on the prices at Lab Corp, you would need to contact Lab Corp and inquire about the price of a plasma draw. The link to the sample is working on our system. If you could please let us know how you are accessing the site (i.e. phone or computer, web browser) we are happy to troubleshoot that for you.

      Thank you for your time.


    • Do you find this question helpful?  Yes   No
  • Cynthia Schoenbauer8/16/14 6:12 AM
    • Hello, Does Dr. Lynch still evaluate each and every one of these tests? Thank you, Cynthia
    • Hello Cynthia,

      Thank you for contacting Seeking Health. Yes, Dr. Lynch evaluates all of the genetic tests purchased on SeekingHealth.com. Your results will be sent with his interpretation of the lab results as well as personalized recommendations for helpful supplements based on your results.

      Thank you for your time,


    • Do you find this question helpful?  Yes   No
  • Pretesting instructions?9/17/14 3:46 PM
    • Hi

      I'm interested in ordering this test, do I need to discontinue any/all supplements I'm currently taking and if so, how long in advance? Specifically curious about the B complex I'm taking.
      In addition I'm also taking fish oil & Vitamin D3 (occasionally).

      Also, I'm getting some genetic testing done (23andme), which will include C677T & A1298C, would it be helpful to Dr Lynch to have those results available when interpreting this test?

    • Hello Peter,

      Thank you for contacting Seeking Health regarding the Methylation Profile Test. An overnight fast is required for accurate test results. Discontinuing all supplementation is not needed; however certain supplements should be stopped in order to see how your methylation is working without supplementation.

      Discontinue the following for 24 hours:

      • SAMe
      • NAC
      • Glutathione
      • B6
      • B12
      • TMG
      • Folate

      This depends on whether your doctor is interested in determining how your methylation is working independent of supplementation or in determining the effectiveness of a supplement regimen. Some doctors want patients to continue supplementation prior to taking this test to see how the supplements are affecting methylation pathways.

      Dr. Lynch recommends taking this test without supplementation as a baseline to see how your body is functioning on its own. Then, he suggests making changes based on the lab findings using lifestyle, diet and supplements for a couple months and testing again – again without supplementation. This will allow both patient and doctor to see if making these changes has produced a meaningful change in methylation processes.

      At this time, Dr. Lynch is not doing personal consultations - you will receive his interpretation of those tests that are purchased through seekinghealth.com. We are not able to send your results from other tests to Dr. Lynch. Thank you for your time and understanding.


    • Do you find this question helpful?  Yes   No
  • Claire11/10/14 3:53 PM
    • Can I have this test sent to UK? I believe I can deliver back in under 48hrs.
      Is this a blood test?
    • Hello,

      Thank you for contacting Seeking Health regarding the Methylation Profile Test from Doctor's Data. This test is a blood test - it is not available to International customers, including those in the UK, due to regulations on shipping blood samples and time constraints. The lab will not ship this test internationally. Thank you for your time.


    • Do you find this question helpful?  Yes   No
  • Methylation Issues11/21/14 6:17 PM
    • Would this test tell if someone had over or undermethylation? And would it also indicate if there is an issue with MTHFR?
    • Hello,

      Thank you for contacting Seeking Health regarding the Doctor's Data Methylation Profile Test. This product can provide useful insight into your levels of co-factors and metabolites of the methylation process. This can help to determine whether you are an "overmethylator" or an "undermethylator." This test is not a gene test, however - it will not tell you for certain whether you do or do not have a particular gene mutation. However, it can provide Dr. Lynch and/or your healthcare provider with some clues as to the likelihood that you do have one or more of the MTHFR gene mutations. Thank you for your time.


    • Do you find this question helpful?  Yes   No
  • Mthfr1/9/15 7:51 PM
    • Hi, I'm looking for guidance on which tests I should get for my 3 year old daughter with many neurological conditions. Which ones and in what order would offer a comprehensive look at mthfr? Thanks so much
    • Hello,

      Thank you for contacting Seeking Health regarding the MTHFR tests. These might be some good resources for you in determining which tests would be valuable for you and your daughter:


      We offer some straightforward genetic tests to determine whether your daughter actually has one or both of the MTHFR gene mutations: SpectraCell MTHFR Test and Molecular Testing Labs MTHFR Test. These tests offer the same information - but the first is a blood test and the second is an oral swab test. It is only necessary to do one or the other.

      Once you know whether your daughter has the MTHFR mutation(s), you can also proceed to use either the Doctor's Data Methylation Profile Test or the Health Diagnostics and Research Institute Methylation Pathway Panel for a more detailed look at her methylation process. These tests provide additional information about the metabolites of folate and cofactors of methylation. They can provide a healthcare professional with information about where in the methylation process your daughter is "stuck" and also give information about actions or supplements to take for support. See the product questions on the product page for the Health Diagnostics and Research Institute test for a comparison of these two tests.

      I hope this helps. Thank you for your time.


    • Do you find this question helpful?  Yes   No

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