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L-Glutamine Powder - 300 Grams - Research

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L-Glutamine Powder

Glutamine, or l-Glutamine, is the most abundant amino acid in the body, and is generally synthesized by the body and obtained from the diet in sufficient amounts. Under stressful conditions, however, the demand for glutamine can exceed the supply. L-Glutamine is therefore classified as a conditionally essential amino acid and has been investigated for a variety of clinical applications. Dosages up to 55 grams per day have shown no adverse side effects in clinical trials (l-Glutamine by Seeking Health provides 5000 mg per serving)1,2

Glutamine & Intestinal Health

Diets including l-Glutamine were found in animal studies to improve markers of intestinal health, including mitigating the harmful effect of pathogenic organisms such as H. pylori that can inhabit the intestines. Glutamine may also modify the conditions of the GI tract in favor of beneficial probiotic organisms.3,4

Supplemental glutamine may also be of benefit for diabetes mellitus related neuropathy; a recent animal study found that supplementing with l-Glutamine promoted a neuroprotective effect.5

Increasing the amount of l-glutamine available was found to have a beneficial effect on intestinal permeability and absorption in patients being treated with fluorouracil for colorectal cancer.6

Glutamine & Immune Function

Glutamine has also been investigated for its effect on immune cell function. A study using rats fed diets with varying amounts of glutamine found that T lymphocyte cell response was improved in the group fed a glutamine-enriched diet, suggesting that the amount of available glutamine can affect the immune system at the cellular level.


1. Wernerman J. Clinical use of glutamine supplementation. J Nutr. 2008 Oct;138(10):2040S-2044S.

2. Watford M. Glutamine Metabolism and Function in Relation to Proline Synthesis and the Safety of Glutamine and Proline Supplementation. J Nutr. 2008 Oct;138(10):2003S-2007

3.S.S. Chamorro, C. de Blas, G. Grant, I. Badiola, D. Menoyo and R. Carabaño. Effect of dietary supplementation with glutamine and a combination of glutamine-arginine on intestinal health in twenty-five-day-old weaned rabbits. J Anim Sci 2010.88:170-180.

4.Amagase K, Nakamura E, Endo T, Hayashi S, Hasumura M, Uneyama H, Torii K, Takeuchi K. New frontiers in gut nutrient sensor research: prophylactic effect of glutamine against Helicobacter pylori-induced gastric diseases in Mongolian gerbils. J Pharmacol Sci. 2010 Jan;112(1):25-32.

5.Zanoni JN, Tronchini EA, Moure SA, Souza ID. Effects of L-glutamine supplementation on the myenteric neurons from the duodenum and cecum of diabetic rats. Arq Gastroenterol. 2011 Mar;48(1):66-71.

6.Daniele B, Perrone F, Gallo C, Pignata S, De Martino S, De Vivo R, Barletta E, Tambaro R, Abbiati R, D'Agostino L. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut. 2001 Jan;48(1):28-33.

7.Kew S, Wells SM, Yaqoob P, Wallace FA, Miles EA, Calder PC. Dietary glutamine enhances murine T-lymphocyte responsiveness. J Nutr. 1999 Aug;129(8):1524-31.

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