ProBiota 12 - 50 Billion CFUs - 60 Vegetarian Capsules - Research

ProBiota 12 Maximum Support 50 Billion CFUs

Probiotic bacteria have been extensively researched for their benefits to human digestive and immune function, but a number of factors affect whether or not probiotic supplements are able to reach & colonize your digestive tract. The strains that are selected for use as probiotics must be able to survive the harsh conditions of your stomach & duodenum to get to the intestines where they colonize¹, and they must be provided in sufficient numbers.

Some of the benefits of probiotics for intestinal & digestive health include reducing inflammation, improving digestion & absorption of nutrients, and interfering with pathogenic organisms such as Helicobacter pylori, Clostridium difficile, and others³. Beneficial probiotic bacteria inhibit these harmful bacteria & yeasts by attaching to the intestinal walls, blocking the pathogen from attaching itself, and also as a result of antimicrobial compounds they produce, such as lactic acid or conjugated linoleic acid².

Since about 70% of the immune system’s function is within the intestines, improving intestinal health with probiotics benefits immune function greatly. A number of studies have demonstrated that beneficial probiotic bacteria help improve the body’s immune response⁴. One study using mice sensitized to Ovalbumin found that probiotics reduce allergic symptoms, particularly Bifidobacterium breve5. In a randomized, double-blind study, a mixture of probiotics was found to boost the local immune system in preoperative colorectal cancer patients⁷.

Probiotics are also helpful in the treatment of food allergies and sensitivities. Some cases of lactose intolerance, for example, are secondary to inflammatory bowel conditions. Resolving the inflammation & microbial imbalance in the intestinal tract can restore the ability to produce lactase, thus ending lactose intolerance. Two probiotic strains, including Bifidobacteria lactis, were found to reduce the toxic effects of gliadin from wheat in celiac patients⁶.

Beyond the benefits of probiotics for the GI tract & immune function, probiotics are also being investigated for other health benefits. A 2002 study found that smokers treated with Lactobacillus plantarum exhibited fewer cardiovascular risk factors for arthersclerosis⁸, suggesting that probiotics may be clinically relevant for preventing long-term diseases caused by toxic exposures such as cigarette smoke.

References:

1. Tuomola E, Crittenden R, Playne M, Isolauri E, Salminen S. Quality assurance criteria for probiotic bacteria. Am J Clin Nutr. 2001 Feb;73(2 Suppl):393S-398S.

2. Kim JM, Kim JS, Kim YJ, Oh YK, Kim IY, Chee YJ, Han JS, Jung HC. Conjugated linoleic acids produced by Lactobacillus dissociates IKK-gamma and Hsp90 complex in Helicobacter pylori-infected gastric epithelial cells. Lab Invest. 2008 May;88(5):541-52.

3. Kaushik JK, Kumar A, Duary RK, Mohanty AK, Grover S, Batish VK. Functional and probiotic attributes of an indigenous isolate of Lactobacillus plantarum. PLoS One. 2009 Dec 1;4(12):e8099.

4. Romeo J, Nova E, Wärnberg J, Gómez-Martínez S, Díaz Ligia LE, Marcos A. Immunomodulatory effect of fibres, probiotics and synbiotics in different life-stages. Nutr Hosp. 2010 May-Jun;25(3):341-9.

5. Hougee S, Vriesema AJ, Wijering SC, Knippels LM, Folkerts G, Nijkamp FP, Knol J, Garssen J. Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice: a bacterial strain comparative study. Int Arch Allergy Immunol. 2010;151(2):107-17.

6. Lindfors K, Blomqvist T, Juuti-Uusitalo K, Stenman S, Venäläinen J, Mäki M, Kaukinen K. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol. 2008 Jun;152(3):552-8.

7. Gianotti L, Morelli L, Galbiati F, Rocchetti S, Coppola S, Beneduce A, Gilardini C, Zonenschain D, Nespoli A, Braga M. A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients. World J Gastroenterol. 2010 Jan 14;16(2):167-75.

8. Naruszewicz M, Johansson ML, Zapolska-Downar D, Bukowska H. Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. Am J Clin Nutr. 2002 Dec;76(6):1249-55.

Research Resource:

L. plantarum reduces cardiovascular risk factors in smokers

Quality Assurance Criteria for Probiotic Bacteria

Conjugated linoleic acids produced by Lactobacillus dissociates...in Helicobacter pylori-infected gastric epithelial cells

Functional and probiotic attributes of an indigenous isolate of Lactobacillus plantarum

Immunomodulatory effect of fibres, probiotics and synbiotics in different life-stages

Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice

Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin

A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients