†Restrictions apply (see details)
Login or create an account to earn points.
2X Rewards

Active B12 with L-5-MTHF

60 Lozenges

Key Benefits and Actions*

  • May help support cellular health
  • May help support the normal conversion of homocysteine to methionine
  • May help support cognitive health
  • May help support healthy energy levels

Ships tomorrow if ordered in the next 20 hours and 35 minutes!

Rewards Members will receive 200 Points for reviewing this product upon approval.

Availability: In stock

Learn more about our Autoship Program!

Full 30-Day Returns, Guaranteed.

Our return policy covers full refunds or replacements on items within 30 days of purchase.


Suitable for Vegans and Vegetarians

Free of:

Dairy, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat, Soy, Gluten, GMO

Active B12 with L-5-MTHF Lozenges by Seeking Health provide 800 mcg of pure non-racemic L-methylfolate in an easy-to deliver lozenge, along with two active “coenzyme” forms of vitamin B12. As “coenzyme” forms, methylcobalamin and adenosylcobalamin are the forms required by certain B12-dependent enzymes and reactions within the body. Similarly, L-5-methyltetrahydrofolate is considered an “active” form of folate - the body's most prevalent form of folate in plasma.*

Vitamin B12 is crucial to the formation of healthy red blood cells, energy production, nervous system support, cognitive function, and homocysteine regulation. Folate as L-5-MTHF is also involved in homocysteine metabolism and efficiently supports methylation, DNA biosynthesis, and nervous system function.*

While folate and B12 are now commonly used to fortify cereals and grains, the synthetic forms of these important B vitamins used for fortification are often not well absorbed, nor added in amounts sufficient to meet the nutritional requirements of all individuals. Natural food sources of folate include liver, dark green leafy vegetables, avocado, peas and beans. Vitamin B12 is naturally present in seafood, shellfish, liver, eggs and dairy products. It may be harder for vegetarians and vegans to meet their daily needs for vitamin B12 from food sources without relying on supplements or fortified foods.*

As each individual may have different needs for vitamin B12 and folate, the potent doses of these vitamins contained in Active B12 with L-5-MTHF may not be ideal for everyone. Working with a qualified healthcare professional is the best way determine the appropriate dose for your individual needs. The lozenges can be broken down into halves or quarters if a lower dose is desired.

Also consider our Optimal Liposomal Active B12 with L-5-MTHF, providing 5,000 mcg of methylcobalamin B12 and 100 mcg of L-5-MTHF per serving, in a soy-free liposomal format for optimal absorption. For greater flexibility and dosage customization, consider our standalone Active B12 5000 and L-5-MTHF Lozenge.*

Suggested Use

Take 1 lozenge daily, or as directed by your healthcare practitioner. Lozenge may be broken into smaller pieces if lower dosage is desired.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. Consult with a healthcare professional before use if you are using antibiotics or other medications.

Serving Size: 1
Servings Per Container: 60

Supplement Facts

Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt) 800 mcg DFE 200%
Vitamin B12 (80% as methylcobalamin and 20% as adenosylcobalamin) 1000 mcg 41667%
% DV (Daily Value) based on standard 2,000 calorie daily intake
**Daily Value not established

Other Ingredients: Xylitol, ascorbyl palmitate, natural cherry flavor, and silica.

Additional Info
Additional Info
Learning Center Find product FAQ and more! Click here.
Cost Per Serving $0.33
Delivery Method Lozenge
Tablet Size 11/32"
Storage Keep closed in a cool, dry place out of reach by children.
Age Suitability Adult
Manufactured In USA
Case Quantity 24
Dimensions (in.) Length: 1.875 / Width: 1.875 / Height: 3.25
Weight (lb.) 0.0500
Barcode 700580723428
Return Policy 30 Day Returns ― Learn more about our Return Policy.
Customer Reviews (212)
Great product
Both my daughter and I had been diagnosed with a MTHFR mutation. I decided to try this product since it was sublingual. I figured it would be easier for her to take, and I thought it might be better absorbed for us. It was very easy to take. It dissolved quickly and had a pleasant taste. We are both feeling good so far, and are pleased with the product! Review by Natasha (Posted on 1/8/2013)
I have found this to be very effective.
I have reduced my other medications by 1/2 since starting on this regimen in August. Review by Super Dave (Posted on 1/8/2013)
So so...
I have MTHFR so I know I needed a product like this. I started slowly so I wouldn't have a bad reaction and worked my way up to 5 pills a day. I did not notice any changes which I thought was weird. But I know I need it so I'll continue with it. Just thought it would make me feel better. Oh and I had no side effects with it. Review by jovanb77 (Posted on 1/8/2013)
Positive results
I have idiopathic peripheral neuropathy. The tingling in my feet has dissipated since taking this product. I am please so far and will continue to take this product. Review by Nancy (Posted on 1/8/2013)
Use it daily
We are using Active B12 with L-5-MTHF every day. We have tried other forms of folate, but this one clearly works better for the people in our family with MTHFR. We haven't had any problems or side effects, and take one tablet daily. Review by Barbara (Posted on 1/8/2013)
Great Product!
I was recently diagnosed compound heterozygous for MTHFR. My homeopath sold me a bottle of Methylfolate (as Quatrefolic) 10 mg and told me to take half a capsule in addition to the methylcobalamin that I already have been taking twice a week. I had a very uncomfortable reaction to it, but it is not easy to measure out smaller amounts of powder from a tiny capsule. I was thrilled to discover Dr. Ben's website and learn that it is not advisable to start patients off on such high amounts. I immediately ordered the Active B12 with methylfolate and started with a quarter pill as suggested. I am up to a full pill every morning and am feeling good with no uncomfortable side effects. I will continue to increase the amount slowly to get my body used to the supplement. I would highly recommend this product! Review by Arielle (Posted on 1/8/2013)
Great product with super savings.
I was diagnosed with peripheral neuropathy and had been using Metanx or it's generic (1 tablet/day) for sometime. Then I found the pleasant tasting Seeking Health Active B-12 Lozenge with L-5-MTHF (2 tablets/day) to be an effective alternative at more than half the cost. Review by Phil - order#4506 dated 27Aug2012 (Posted on 12/3/2012)
Life Renewing!
I was recently diagnosed with homozygous MTHFR a1298c. I started with 1/4 tablet for 4 days, then half for two days. Am not having afternoon/evening extreme fatigue as before I began and notice a subtle lightness in spirit. I am amazed at how quickly I feel improvemets. Will keep at half tablet for awhile and plan to order the multivitamin! Thank you, Dr. Lynch! Review by Karen (Posted on 10/31/2012)
Great products
This pill taste great, does not cause dry mouth and dissolves quickly. I have only been using if for a few days but feel good about my decision to take this supplement over the folic acid my doctor recommended due to my diagnosis showing I am compound heterozygous for MTHFR. (Order # 5447) Review by Amber (Posted on 10/22/2012)
Powerful pill
I have MTHFR C677T, have been taking Sublingual Active B12 with Metafolin, 4 pills a day, feeling great. No side effect except my period cycle prolonged. I changed to HomocysteX last month, did not feel good. So I switched back to Sublingual Active B12 with Metafolin, felt good again. Review by jchendyu (Posted on 10/16/2012)
Sublingual B
We purchased this product to supplement the methly folate prescribed by my daughter's naturopath, for her newly diagnosed MTHFR (compound hetro with one of each mutated genes). It tastes pleasant-surprising for anything with B in it :)

Great customer service, great product, looking forward to trying more of the Seeking Health Brand products!
Review by evy (Posted on 6/27/2012)
I've been using these for several weeks and they seem to be working well. I'm compund heterozygous MTHFR. I've been working up on the dosage and am getting ready to go to 2 1/2 per day. Review by Kelly (Posted on 6/25/2012)

Items 201 to 212 of 212 total

per page
  1. 1
  2. ...
  3. 7
  4. 8
  5. 9
  6. 10
  7. 11
Write Your Own Review

Only registered users can write reviews. Please, log in or register

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

You may also be interested in the following product(s)
Optimal Electrolyte Berry Optimal Electrolyte Berry
21 Review(s)
Niacin Lozenge Niacin Lozenge
24 Review(s)

You demand the best for you and your family. We research so we can give it to you. Our rapid growth is a testament to you, our customers.
Seeking Health is a proud honoree of Inc. 5000’s fastest-growing companies in America for the third year in a row.

NSF GMP Registered
BBB Accredited