Histamine Block Plus - 60 Capsules

Rated 5.0 out of 5
Based on 5 reviews

List price: $

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Key Benefits and Actions*

  • Promotes a healthy response to high-histamine foods
  • Enhanced with cofactor nutrients for total histamine processing
  • Great for supporting histamine intolerance protocols

Too much histamine in your body can contribute to symptoms such as flushing, runny nose, sleep difficulties, and/or headaches. These pesky symptoms can be the result of slowed enzyme activity in your histamine pathway. While DAO is the main enzyme responsible for breaking down food-derived histamine in your gut, other enzymes also play critical roles in metabolizing histamine produced in your body. To support your entire histamine pathway, Dr. Ben Lynch formulated one of the first and only products including the specific nutrients your histamine enzymes need to function.*

Histamine Block Plus is a comprehensive formula containing seven essential nutrient cofactors plus powerful antioxidants to support total histamine metabolism in each and every cell.*

Toxic byproducts are created when histamine is metabolized, such as ammonia, hydrogen peroxide, and acetaldehyde that can cause side effects and cell damage. Histamine Block also contains nutrient cofactors to support the normal breakdown of these toxic byproducts.*

Histamine Block Plus is a synergistic blend of nutrients designed to support the normal breakdown of histamine through multiple enzymatic processes, as well as neutralizing the toxic byproducts of histamine, using key nutrients:*

  • DAO — Contains 5,000 HDU of a patented DAO, a major enzyme responsible for breaking down histamine
  • Copper — A nutrient cofactor for the DAO enzyme
  • SAMe — A nutrient cofactor for the HNMT enzyme, another major enzyme involved in histamine breakdown
  • Alpha Keto-Glutarate — Supports the normal breakdown of ammonia, which is a toxic byproduct of histamine metabolism
  • Riboflavin — A nutrient cofactor for the MAOA and MAOB enzymes, which aid in neutralizing histamine toxic byproducts
  • Zinc and Vitamin B3 — Nutrient cofactors for the ALDH enzyme family, which help to break down acetaldehyde, a toxic byproduct of histamine metabolism

  • These key nutrients plus other powerful ingredients create the perfect support to your histamine intolerance protocol. Finally, you can experience a healthy response to histamine!*

    Suggested Use

    Take 2 capsules no more than 15 minutes before consumption of histamine-rich foods, or use as directed by your healthcare professional. 


    Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient. Histamine Block Plus is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. DAO is not absorbed and does not have systemic activity. Histamine Block Plus does not manage or address antibody-related or IgE-related food allergies.

    Allergy and Diet Information

    • Histamine Block Plus is NOT suitable for vegans or vegetarians, as it contains porcine-derived ingredients.
    • Histamine Block Plus is free of milk, egg, fish, shellfish, tree nuts, peanuts, wheat, soy, gluten, GMOs, artificial colors, artificial flavors, and artificial preservatives.
    • Histamine Block Plus meets or exceeds cGMP Quality Standards.

    When taking Histamine Block Plus, consider these complementary products as recommended by Dr. Ben Lynch:

    • ProBiota HistaminX A probiotic formulated to exclude strains known to produce histamine to support a balanced microflora and gut health response to histamine ingestion.*
    • HistaminX - A bioflavonoid-based formula that supports healthy histamine release and healthy immune system responses.* This makes a great pair to Histamine Block Plus!
    • Optimal Electrolyte Electrolytes are key for hydration and for supporting the absorption of nutrients into cells, as well as supporting lost electrolytes that occur during cell division.*
    • Optimal PC Contains phosphatidylcholine, a nutrient used to build cell walls and support normal histamine release and regulation.* 
    • Optimal Liposomal Vitamin C Vitamin C is needed for optimal histamine response and DAO production. This optimally-absorbed vitamin C formula is one of our best sellers.*

      Serving Size: 2 Capsules
      Servings Per Container: 30

      AMT %DV
      Vitamin C (as ascorbic acid) 100 mg 111%
      Thiamine (as thiamine hydrochloride) 20 mg 1,667%
      Riboflavin (as riboflavin 5'-phosphate sodium) 10 mg 769%
      Niacin 25 mg 156%
      Vitamin B6 (as pyridoxal 5'-phosphate) 7 mg 412%
      Pantothenic Acid (as d-calcium pantothenate) 10 mg 200%
      Magnesium (as DiMagnesium Malate§) 50 mg 12%
      Zinc (as zinc gluconate) 5 mg 45%
      Copper (as copper gluconate) 0.5 mg 56%
      Alpha-Ketoglutaric Acid 150 mg **
      SAMe (as disulfate ptoluensulfonate) 100 mg **
      PQQ (as LifePQQTM pyrroloquinoline quinone disodium salt) 7 mg **
      DAO2TM porcine kidney extract (Diamine Oxidase Activity 5,000 HDU) 2.1 mg **
      **Daily Value (DV) not established.

      Other Ingredients: Vegetarian capsule (hypromellose, water, and gellan gum), microcrystalline cellulose, ascorbyl palmitate, and silica.
      §Albion®, TRAACS® and the Albion Gold Medallion design are registered trademarks of Albion Laboratories, Inc.
      DAO2TM is a licensed trademark of Diem Direct, LLC used with permission.

      Learning Center Find product FAQ and more! Click here.
      Cost Per Serving $1.00
      Delivery Method Vegetarian Capsule
      Capsule Size 0
      Storage Keep tightly closed in a cool, dry place out of reach by children.
      Age Suitability Adult
      Manufactured In USA
      Case Quantity 24
      Dimensions (in.) Length: 2.00 / Width: 2.00 / Height: 3.75
      Weight (lb.) 0.05
      Barcode 810007521589
      Return Policy Learn more about our Return Policy.
      average rating 5.0 out of 5
      Based on 5 reviews
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      100% of reviewers would recommend this product to a friend
      5 Reviews
      Reviewed by Christina, from United States
      Verified Buyer
      I recommend this product
      Rated 5 out of 5
      Review posted


      I have the mthfr variant and have really struggled with histamine. My nose is constantly stuffy. I follow Dr. Lynch and watched a video he did talking about this product and his son’s response to it. I was hopeful it would help me like it’s helped others and it is. I feel less stuffiness just 20 to 30 minutes after taking it. Very thankful for the relief.

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      Reviewed by CM, from United States
      Verified Buyer
      I recommend this product
      Rated 5 out of 5
      Review posted

      Histamine Block Plus is working for me!

      I just started taking it and it is really helping me breathe through both nostrils and quelling hives that I can get from pollen, wind, eating. I watched a video by Dr. Lynch on Instagram this week and started using it before/after hikes with my dog when pollen is high as well as before a meal. Sometimes after as well if I've had a little swelling in my forehead/eyes. It's a true find. I tried the Histamine Block (DAO only) several years ago and it didn't seem to help me, but I realize I was taking it wrong - I was taking it daily rather than just before a meal. Wondering if taking the Histamine Block + Block Plus would be even a strong combination?

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      Reviewed by ermorriak, from United States
      Verified Reviewer
      I recommend this product
      Rated 5 out of 5
      Review posted

      Just ordered!

      I can't wait to try this new Histamine Block Plus. I have been a loyal user of the original Histamine Block for 3 years now and it has been life changing with my food intolerances and headaches! I'll post another review after a few weeks of trying this new formula! Can't wait to receive it!

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      Reviewed by Cara M., from United States
      I recommend this product
      Rated 5 out of 5
      Review posted

      Histamine Block for Hives

      I have been suffering with hives for years. And by hives I mean giant welts sporadically all over my body. I cut out wheat/gluten and cut back my sugar intake. The hives got better but I still would

      get 3-4 welts a week. I have been taking Histamine Block before meals for one week and NO HIVES OR WELTS! It’s only been a week but I am going to keep taking and see if it helps permanently.

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      Reviewed by Sunny C., from United States
      Verified Buyer
      I recommend this product
      Rated 5 out of 5
      Review posted

      This will help me out tremendously

      I usually take Benadryl when I eat histamine rich foods which ends up making me wanna nap so this will help me out tremendously thank you so much. Sidenote! Wow every vitamin supplement should have that bottle shape I hate trying to drag a vitamin out of a freaking skinny neck from the side of the bottle this bottle is amazing. No more dropping vitamins on the ground! Every vitamin supplement should have this bottle shape!

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