Been taking this product for over 7 years. I am sensitive to methyl groups and can't take methyl B-12 or methylfolate products by swallowing as they get into my liver too fast and make me jittery and unable to sleep for days. So the sublingual form is perfect as it bypasses the liver and allows me to take just what I need. Since this is in tablet form, I am able use a pill cutter to quarter it and take what I need each day. Thank you for for this product!
Active B12 with L-5-MTHF Lozenges by Seeking Health provide 1,360 mcg DFE (800 mcg) of pure non-racemic L-methylfolate in an easy-to deliver lozenge, along with two active “coenzyme” forms of vitamin B12. As “coenzyme” forms, methylcobalamin and adenosylcobalamin are the forms required by certain B12-dependent enzymes and reactions within the body. Similarly, L-5-methyltetrahydrofolate is considered an “active” form of folate - the body's most prevalent form of folate in plasma.*
Vitamin B12 is crucial to the formation of healthy red blood cells, energy production, nervous system support, cognitive function, and homocysteine regulation. Folate as L-5-MTHF is also involved in homocysteine metabolism and efficiently supports methylation, DNA biosynthesis, and nervous system function.*
While folate and B12 are now commonly used to fortify cereals and grains, the synthetic forms of these important B vitamins used for fortification are often not well absorbed, nor added in amounts sufficient to meet the nutritional requirements of all individuals. Natural food sources of folate include liver, dark green leafy vegetables, avocado, peas and beans. Vitamin B12 is naturally present in seafood, shellfish, liver, eggs and dairy products. It may be harder for vegetarians and vegans to meet their daily needs for vitamin B12 from food sources without relying on supplements or fortified foods.*
As each individual may have different needs for vitamin B12 and folate, the potent doses of these vitamins contained in Active B12 with L-5-MTHF may not be ideal for everyone. Working with a qualified healthcare professional is the best way determine the appropriate dose for your individual needs. The lozenges can be broken down into halves or quarters if a lower dose is desired.
For greater flexibility and dosage customization, consider our standalone Active B12 5000 and L-5-MTHF Lozenge.*
Suitable for Vegans and Vegetarians
Milk, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat, Artificial Colors, Artificial Flavors
Take 1 lozenge daily, or use as directed by your healthcare professional. Lozenge may be broken into smaller pieces if lower dosage is desired. Do not take within 5 hours of bedtime as it may interfere with sleep.
Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. Consult with a healthcare professional before use if you are using antibiotics or other medications.
Serving Size: 1 Lozenge
Servings Per Container: 60
|Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt)||1360 mcg DFE (800 mcg)||340%|
|Vitamin B12 (80% as methylcobalamin and 20% as adenosylcobalamin)||1000 mcg||41,667%|
Other Ingredients: Xylitol, ascorbyl palmitate, natural cherry flavor, and silica.
1. Who is Active B12 with L-5-MTHF intended for?
Active B12 with L-5MTHF Lozenges provide 800 micrograms of pure L-methylfolate along with the two primary active forms of B12, all in an easy-to-take lozenge. This product is intended for any adult who wants to naturally support MTHFR mutations, support healthy mental clarity, focus, attention, as well as positive mood and energy.*
Vitamin B12 is essential for the formation of healthy red blood cells, energy production, nervous system support, cognitive function, and homocysteine regulation. Folate is involved in homocysteine metabolism and efficiently supports methylation, DNA biosynthesis, and nervous system function.*
While folate and B12 are now commonly used to fortify cereals and grains, the synthetic forms of these important B vitamins used for fortification are often not well absorbed, nor added in amounts sufficient to meet the nutritional requirements of all individuals. Natural food sources of folate include liver, dark green leafy vegetables, avocado, peas, and beans. Vitamin B12 is naturally present in seafood, meat, shellfish, liver, eggs, and dairy products. It may be harder for vegetarians and vegans to meet their daily needs for vitamin B12 from food sources without relying on supplements or fortified foods.*
As each individual may have different needs for vitamin B12 and folate, the potent doses of these vitamins contained in Active B12 with L-5MTHF may not be ideal for everyone. Working with a qualified healthcare professional is the best way to determine the appropriate dose for your individual needs.*
Always talk to your doctor before considering the use of this product, especially if you have health conditions or diseases that need to be addressed or are pregnant or breastfeeding.
2. How do I take Active B12 with L-5-MTHF?
Take 1 lozenge daily or as directed by your healthcare practitioner. Lozenge may be broken into smaller pieces for a lower dosage if desired. Do not take within 5 hours of bedtime as this product may interfere with sleep.
3. What is the reasoning for each ingredient in Active B12 with L-5-MTHF?
|Folate||Supports homocysteine metabolism, methylation processes, and nervous system.*|
|Vitamin B12||Natural energy, methylation processes, and nervous system support.*|
Other ingredients found in this product include:
- Xylitol: Sweetener.
- Ascorbyl palmitate: Protects shelf-life of product.
- Natural cherry flavor: Flavoring.
- Silica: Anti-clumping agent.
4. What are the ingredients in Active B12 with L-5-MTHF derived from?
Vitamin B12 as adenosylcobalamin is from fermentation.
Vitamin B12 as methylcobalamin and folate are synthetic.
5. Does Active B12 with L-5-MTHF contain gluten, soy, or grains?
This product is tested and confirmed to be free from gluten and soy allergens. It contains ascorbyl palmitate, a product derived from corn, but due to processing, it is considered to be non-allergenic.
6. Is Active B12 with L-5-MTHF free from GMOs?
Testing verifies that this product is free from GMO markers.
7. Is Active B12 with L-5-MTHF vegetarian/vegan?
This product is both vegetarian and vegan.
8. What are the possible interactions or side effects of using Active B12 with L-5-MTHF?
Possible side effects of this supplement include:
- Rash Itching Mild fever Stomach upset Gastrointestinal complaints Insomnia Irritability Fatigue
Individuals who have recently undergone surgery for a coronary stent should avoid using B12.*
If you believe that you are experiencing any adverse reactions, please see your healthcare professional immediately and discontinue use. Each individual may react differently to any product or supplement. We always recommend that you consult with your healthcare professional prior to considering the use of this or any supplement, especially when pregnant or breastfeeding.
9. What is the difference between the types of B12?
There are four types of B12: adenosylcobalamin, hydroxocobalamin, methylcobalamin, and cyanocobalamin.
- Adenosylcobalamin: A primary form of B12 in the body that is mostly concentrated in cellular tissues.
- Hydroxocobalamin: Supports natural detoxification pathways and easily converts into methylcobalamin, the most active form.
- Methylcobalamin: A primary form of B12 in the body that is mostly concentrated in blood plasma.
- Cyanocobalamin: None of our products contain this form. This is the inactive form that is paired with a cyanide molecule and is the most difficult to absorb and use in the body.
Your healthcare provider will be the best person to determine which form(s) are optimal for your health needs.
10. Does Active B12 with L-5-MTHF absorb better if chewed or dissolved sublingually?
This product is meant to be taken orally and swallowed. Absorption rates will vary from person to person and due to a number of other factors, including enzyme activity, diet, age, size, etc.*
|Learning Center||Find product FAQ and more! Click here.|
|Cost Per Serving||$0.33|
|Storage||Keep closed in a cool, dry place out of reach by children.|
|Dimensions (in.)||Length: 1.875 / Width: 1.875 / Height: 3.25|
|Return Policy||Learn more about our Return Policy.|
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Great combination and product!
Active B12 with L-5 MTHF has everything I was looking for in one lozenge.
I’m very satisfied with this supplement as well as the company Seeking Health. I have checked many companies that sell supplements and Seeking Health meets my requirements for a qualified company to include research and quality ingredients. I love having a high dose methylation supplement B12 as well as folate. I am vegan and I’m not always able to eat enough of the appropriate foods to meet the appropriate doses of B12 or folate. I feel assured these needs are met with this product.
Tastes great, works great
Easily absorbed B12 that tastes great, too. A win, win!