Magnesium Plus contains two bioavailable forms of magnesium and the active form of vitamin B6. This combination supports optimal magnesium levels in your body. Each serving provides 125 mg of elemental magnesium in the superior malate and glycinate forms. A gentle serving of P-5-P (30 mg) is included to support optimal magnesium absorption.^†

P-5-P (pyridoxal 5’-phosphate) is considered by many to be the best form of vitamin B6. This form is thought to be better for those who have trouble converting pyridoxine HCL into an active form that can be utilized by the body. Up to 90 percent of your body’s vitamin B6 is made by gut bacteria. Due to poor diet, modern living, and genetic variations, many people are deficient in this essential B vitamin.^†

P-5-P has been shown to increase absorption of magnesium into red blood cells to support healthy magnesium levels. P-5-P also pairs well with magnesium to promote healthy female menstrual cycles and hormone metabolism prior to menstruation. It may also support stomach comfort and digestion due to occasional nausea or morning sickness during pregnancy.^†

Magnesium glycinate is a well-tolerated form of magnesium bound to the amino acid glycine. Glycine is the most basic of all amino acids. By attaching magnesium to glycine, it greatly increases absorption of this mineral. When unabsorbed magnesium is left in the intestines, water is released from the intestinal lining to flush it out. This contributes to the cramping, indigestion, heartburn, loose stools, and discomfort associated with magnesium supplementation. Magnesium glycinate is one of the best choices for people with sensitive stomachs who have not previously tolerated magnesium. It is also ideal for those seeking the calming benefits of glycine, which acts as a neurotransmitter in the brain to support feelings of calm and relaxation.^†

Magnesium malate is another well-tolerated form of magnesium bound to malate (malic acid), an important compound in the Krebs cycle used to produce energy (ATP). Malate’s role in ATP production supports healthy exercise performance and muscle recovery. For these reasons, many people consider magnesium malate ideal for supporting natural energy levels. Magnesium itself is also a vital part of energy production. It plays a key role as a cofactor holding ATP stable in over 300 enzyme reactions in the human body. Binding magnesium to malic acid amplifies magnesium’s energy benefits.^†

How Magnesium Supports Calm

It may seem counterintuitive that magnesium simultaneously supports energy while also calming the mind and body. One of magnesium’s major roles is related to mood and relaxation via N-Methyl D Aspartate (NMDA) receptors in the brain. Magnesium supports feelings of calm by blocking NMDA. These brain calcium channel receptors are activated by the neurotransmitter glutamate.^†

When we are in danger or starving, brain levels of glutamate increase. Glutamate binds to NMDA receptors, allowing for more calcium to enter neurons. This calcium influx excites neurons, helping us to be alert and awake so we can protect ourselves from potential harm. This excitatory state in the brain is great during emergencies, but not so great when we need to relax. The end result can be feelings of nervousness, racing thoughts, rapid heartbeat, and sleep difficulties.

Magnesium supports relaxation and calm by regulating the amount of calcium that can enter cells via NMDA receptors. By lowering NMDA stimulation, magnesium supports a calm mood and focus. In addition, magnesium is needed for COMT enzyme function, which breaks down dopamine. In excess, dopamine can lead to irritability and nervousness. Consuming a combination of vitamin B6 and magnesium may support a healthy mood and well-being.^†

The P-5-P in this formula further reduces NMDA activation. P-5-P is required as the only cofactor for the enzyme glutamate decarboxylase. This enzyme converts excitatory glutamate into GABA, your body’s primary inhibitory (calming) neurotransmitter. In addition, the magnesium glycinate in this formula contains magnesium attached to glycine. The amino acid glycine acts as an inhibitory neurotransmitter to support feelings of calm and relaxation.^†

Magnesium Plus contains magnesium in the ‘malate’ and ‘glycinate’ forms to support energy while also supporting relaxation. Along with P-5-P, these well-tolerated forms of magnesium offer superior absorption and GI comfort.^†

If you’re looking for a bioavailable form of magnesium, look no further than Magnesium Plus by Seeking Health. For a standalone magnesium glycinate supplement, consider our Magnesium Glycinate Powder. For standalone magnesium malate, try our or Magnesium Malate Chewable or Magnesium Malate Powder. For a blend of magnesium malate and glycinate without the P-5-P, try our Optimal Magnesium.^†