I have both MTHFR variants and my D.O. recommended this supplement. Seems to work great, no side effects, and over time I can see the benefits.
HomocysteX Plus by Seeking Health supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TMG) to synergistically support methylation and normal homocysteine metabolism. Methylation is vital for formation of essential cell components such as proteins, nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes. By transferring methyl groups (three hydrogen atoms bonded to a carbon atom, known as CH3) from one molecule to another, methylation turns on genes, activates enzymes, drives detoxification reactions, influences hormone secretion, and helps maintain normal metabolism of homocysteine, a potentially harmful amino acid metabolite. Unfortunately, poor nutrition, oxidative stress, infections, metabolic defects, and various other factors can impair methylation processes throughout the body.*
To nutritionally support optimal methylation capacity, this product supplies folate, vitamin B12, B6, B2, and betaine in amounts and forms that are efficiently utilized and well-tolerated by the body. Taking just L-5-methylfolate is often times not sufficient for those with MTHFR mutations. Dr. Lynch provides these other ingredients, such as betaine (TMG), to help support healthy homocysteine levels and support the methylation cycle.*
Betaine is a powerful and important methyl donor for the body, especially for those who have MTHFR mutations. Vitamin B12 is crucial to the formation of healthy red blood cells, energy production, nervous system support, cognitive function, and homocysteine regulation. Vitamin B6 as P-5-P is important as a coenzyme for the normal metabolism of amino acids, carbohydrates and lipids. It is also involved in healthy cognitive development, immune health and homocysteine conversion. Riboflavin is important for body growth and red blood cell production and assists in the process of releasing energy from carbohydrates.*
For a methylation support supplement without the betaine, consider our HomocysteX. For a B12- and folate-only product, consider our Active B12 with L-5-MTHF.
Suitable for Vegans and Vegetarians
Milk, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat, Soy, Gluten, GMO, Artificial Colors, Artificial Flavors
Take 1 capsule daily with or without food, or as directed by your healthcare professional. Do not take within 5 hours of bedtime as it may interfere with sleep.
Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. Consult with a healthcare professional before use if you are using antibiotics or other medications.
Serving Size: 1 Capsule
Servings Per Container: 60
|Riboflavin (as riboflavin-5’-phosphate sodium)||25 mg||1,923%|
|Vitamin B6 (as pyridoxal-5’-phosphate)||15 mg||882%|
|Folate [as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt]||1,360 mcg DFE (800 mcg)||340%|
|Vitamin B12 (as MECOBALACTIVE® methylcobalamin and adenosylcobalamin)||1,000 mcg||41,667%|
|TMG (trimethylglycine)||700 mg||**|
|**Daily Value (DV) not established.|
Other Ingredients: Vegetarian capsule (hypromellose and water) and ascorbyl palmitate.
Quatrefolic® is a registered trademark of Gnosis S.p.A. Produced under US Patent 7,947,662.
MECOBALACTIVE® is a registered trademark of HealthTech BioActives SLU d.b.a. Ferrer HealthTech.
|Learning Center||Find product FAQ and more! Click here.|
|Cost Per Serving||$0.47|
|Delivery Method||Vegetarian Capsule|
|Storage||Keep closed in a cool, dry place out of reach by children.|
|Dimensions (in.)||Length: 2 / Width: 2 / Height: 3.75|
|Return Policy||Learn more about our Return Policy.|
Recommended by my D.O.
I’m so happy to have found all seeking health supplements for all the variants I have
I've been taking this for a few months as recommended by my physician and have no complaints. I believe seeking health makes high quality products!
HomocysteX Plus - 60 Capsules
Since getting the results of my Stratagene Test, I have a much better understanding of what my body needs to function better. My histamine level has been a problem for a long time and doctors told me to take a Claritin tablet every day to manage the itching and irritations. I knew this was not dealing with the core issue but found no help until learning from Dr. Lynch. Now I'm cleaning up my genes and supporting the work of my pathways. I may need to use HomocysteX Plus for a long time because I do carry a marker for MTHFR. Finally, after 30 years, I'm getting answers for my health.
I bought this product as I have the MTHFR gene mutation, and I had high homocysteine levels when I found out. Along side other seeking health products over was able to lower my homocysteine from 15.6 to 5.7 in just under 2 months, and raise my B12 levels back to a normal range.