L-Methylfolate Supplements

L-methylfolate is the most abundant form of folate in your body. It is also referred to as active folate or L-5-MTHF. Other types of folate need to be converted into active forms. People with MTHFR gene variants may not be able to activate folic acid. If you are low on this critical nutrient, your methylation cycle won’t work effectively.


Methylation is essential for regulating gene expression and controlling how your DNA works. L-methylfolate supports healthy red blood cells, mental health, and normal homocysteine levels. It is found in foods like leafy greens and liver. If you aren’t eating a lot of these, you may benefit from a dietary supplement to support healthy folate levels.


Seeking Health’s L-methylfolate supplements include L-5-MTHF and Active B12 with L-5-MTHF. You can also get Optimal Prenatal and Optimal Multivitamin, which provide folate along with active vitamin B12 (methylcobalamin), calcium, and other important vitamins and minerals.


Check out this Folate Comparison Chart to select the right folate for you.


Explore L-methylfolate supplementation options below. 


If you find that methylated supplements make you feel jittery or upset, use this comparison chart to learn about the differences between methylated and non-methylated products or check out this article.