Methylation controls multiple biochemical pathways in your body.

Your genetics, heart health, hormones, sleep, stress, mood, and detoxification depend on healthy methylation.

Where does your body get the methyl groups needed to carry out methylation? Primarily from folates that come from food and intestinal microbes. Food folates must be first converted into an active form before your body can use them.^†

Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).^†

Over 50 percent of the population is thought to have a genetic mutation in their MTHFR gene. Thus, they may not be achieving adequate methylfolate levels from food alone.^†

Because L-5-MTHF bypasses the MTHFR enzyme, it can provide methylation support for those with MTHFR polymorphisms.^†

Folate (as bioavailable L-5-MTHF) is:^†

• Easily absorbed and used by cells
• The predominant form of folate in circulation
• The only form of folate that can cross the blood-brain barrier
• Essential for methylation, DNA expression, homocysteine metabolism, and nervous system function

Seeking Health’s L-5-MTHF contains 25,500 mcg DFE of methylfolate in the bioavailable form of L-5-methyltetrahydrofolate (L-5-MTHF).^†

The bioactive form of L-methylfolate (L-5-MTHF) is well-utilized in the methylation cycle. It is often the preferred form for those with methylation, homocysteine, or MTHFR gene mutation concerns.^†

Mutations in your MTHFR gene can lead to reduced L-methylfolate production and a less functional methylation cycle. Challenges in the methylation cycle are associated with an increased risk for cardiovascular and mood issues, birth defects, and infertility concerns.

Mutations in this gene can also slow your body’s ability to convert folate into its active forms. Thus, a large majority of people may benefit from consuming an L-methylfolate dietary supplement.^†

The most direct way to support methylation and MTHFR genetic mutations is with L-methylfolate (L-5-MTHF).^†

Scientific research has demonstrated that higher strengths of L-5-MTHF may also support healthy neurotransmitter formation. A key cofactor is needed for both serotonin and dopamine metabolism. It is called BH4 or tetrahydrobiopterin. It appears that L-5-MTHF may help to both make more BH4 and also regenerate BH4 that has been previously used to make neurotransmitters. By doing so, L-5-MTHF plays an important role in assuring normal neurotransmitter formation takes place.^†

Supplementing with bioavailable L-5-MTHF supports:^†

• Healthy methylation
• Positive mood
• Healthy homocysteine levels
• Nervous system function and development
• Prevention of neural tube defects during pregnancy
• Healthy energy production
• Normal cognitive, memory, and brain function

Our 25,500 mcg DFE capsule was designed for healthcare practitioners to recommend to their clients who they have identified as requiring extra support for methylation or neurotransmitter metabolism. This higher dose of folate is reserved for healthcare practitioners or clients who have been guided by their healthcare practitioners to address their increased needs. If you or your practitioner are concerned with getting too many methyl groups when taking a higher dose of L-5-MTHF, chemistry shows that the ingestion of higher levels of both glycine (an amino acid found in collagen) and niacin may support normal levels of methylation reactions.^†

Get ready for your methylation cycle to fire on all cylinders with Seeking Health’s L-5-MTHF!^†