SAMe - 30 Capsules

Rated 4.8 out of 5
Based on 59 reviews
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Key Benefits and Actions*

  • May help support healthy mood
  • May help support healthy connective tissues
  • May help support normal glutathione levels and liver health
  • May help support healthy methylation processes


SAMe by Seeking Health provides 250 mg of S-adenosyl-L-methionine (SAMe) in each protective, acid-resistant vegetarian capsule. To optimize stability and prevent degradation on exposure to environmental factors, the capsules are protected from moisture and air via a desiccated bottle.*

SAMe is the body's main methyl donor - it is found in nearly every tissue and fluid in the human body. SAMe is naturally produced from the amino acid methionine and ATP. It is involved in the synthesis and regulation of chemicals in the brain, the maintenance of healthy cell membranes, the ATP cycle, and both methylation and transsulfuration pathways. As a sulfur-containing compound, SAMe is also important for normal production of glutathione, cysteine and taurine and may therefore be implicated in maintaining healthy liver function. Due to its role in supporting healthy synthesis of connective tissues, SAMe may also help support bone and joint health.*


Suitable for Vegans and Vegetarians

Free of:

Milk, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat, Artificial Colors, Artificial Flavors

Suggested Use

Take one capsule 45 minutes before or 60 minutes after a meal or as recommended by your healthcare professional. Taking away from food increases absorption.


Children and pregnant or lactating women should consult their healthcare professional prior to use. Do not use if tamper seal is damaged. Consult with a healthcare professional prior to use if you have any medical conditions. Individuals taking medications of any kind, especially for depression or anxiety, or MAOIs, should consult with a healthcare provider prior to taking this supplement.

Serving Size: 1 Capsule
Servings Per Container: 30

SAMe (S-adenosyl-L-methionine) 250 mg **
**Daily Value (DV) not established.

Other Ingredients: Acid-resistant capsule (hypromellose, gellan gum, and water), ascorbyl palmitate, silica, and microcrystalline cellulose.

Learning Center Find product FAQ and more! Click here.
Cost Per Serving $1.00
Delivery Method Vegetarian Capsule
Capsule Size 0
Storage Keep closed in a cool, dry place out of reach by children.
Age Suitability Adult
Manufactured In USA
Case Quantity 12
Dimensions (in.) Length: 1.25 / Width: 5.75 / Height: 4
Weight (lb.) 0.1000
Barcode 798295549181
Return Policy Learn more about our Return Policy.

We are not able to publish reviews that reflect atypical results or suggest that any product can diagnose, treat, cure, or prevent any disease, disorder, or chronic health condition. Please be mindful of these restrictions as you leave your review and thank you for all your feedback!

average rating 4.8 out of 5
Based on 59 reviews
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59 Reviews
Reviewed by Erin, from United States
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Finally sleeping through the night!

I'm Finally sleeping through the night and not needing to go to the bathroom in the middle of the night after starting SAMe! I've been working with a Functional medicine Dr and through diet, lifestyle and supplements i have improved my health tremendously but still wasn't able to sleep all night. On day 2 of taking this I finally am! Highly recommend!

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Reviewed by Angela H., from United States
I recommend this product
Rated 4 out of 5
Review posted

Don't feel a major difference

Not sure if it is just me, but I am sure it works well like the other projects.

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Reviewed by Kimberly S., from United States
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

No more headaches from B vitamins

Since I was little, supplemented b vitamins gave me massive headaches if I took them more than three to four days in a row. I couldn’t take multivitamins, or most designer supplements because of this.

I tried all the different forms of B-12, I tried methylated versions of b vitamins. Same result. Then a naturopath recommended Sam-e, both for b vitamin metabolism and histamine intolerance.

I’m so thrilled to say it worked.

I can now take any b vitamins as long as I take Sam-e the same day and not get a knock-out headache. It has also helped with histamine intolerance, both on its own and because I can take B6 to support my histamine pathways.

I take it most days, but on days I’m snacking more, I tend to forget since you have to take it away from food.

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