Histamine Block

Rated 4.7 out of 5
Based on 343 reviews

List price: $

$29.95 You save: $$$ (%)

Key Benefits and Actions*

  • Comfort and relief after eating foods high in histamine
  • Patented enzyme formula replenishes DAO in your gut
  • Great for histamine intolerance protocols

Histamine Block is now packaged in a moisture-controlled, desiccated bottle for enhanced product stability and potency. This new packaging delivers unparalleled protection for products that are sensitive to outside moisture. A desiccant sleeve surrounds the product creating an impenetrable barrier, contributing to greater product stability over time. Research has shown this container system to be more effective than standard bottles containing desiccants or even blister packs.

Histamine Block by Seeking Health contains a patented enzyme formula providing 10,000 HDU of diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine - per capsule. Histamine is known as a biogenic amine, an organic nitrogen compound, involved in certain immune responses and found in mast cells. It may be involved in regulating healthy function in the GI tract as well as the nervous system. Histamine also plays an important role in triggering the body’s normal inflammatory response.

An excess of histamine can be problematic, however, leading to histamine sensitivity/intolerance, digestive concerns, allergies, and more. Individual sensitivity to histamine varies, and some individuals may be more reactive to histamines and other biogenic amines in foods. Diamine oxidase (DAO) has been clinically tested and found to break down food-derived histamine in the digestive tract. Note that DAO is not absorbed and does not have systemic activity. Histamine Block does not manage or address antibody-related or IgE-related food allergies.*

For a similar formula with added cofactor nutrients, try Histamine Block Plus.

To help maintain your body's natural first line of defense against ingested histamine - your gut - try ProBiota HistaminX.* 

Suggested Use

Take 1 capsule no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient. Histamine Block is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. DAO is not absorbed and does not have systemic activity. Histamine Block does not manage or address antibody-related or IgE-related food allergies.

Allergy & Diet Information

  • Histamine Block is NOT suitable for vegans or vegetarians, as it contains porcine-derived ingredients.
  • Histamine Block is free of milk, egg, fish, shellfish, tree nuts, peanuts, wheat, soy, gluten, GMOs, artificial colors, artificial flavors, and artificial preservatives.
  • Histamine Block meets or exceeds cGMP Quality Standards.

    When taking Histamine Block, consider these complementary products as recommended by Dr. Ben Lynch:
  • ProBiota HistaminX — A probiotic formulated to exclude strains known to produce histamine to support a balanced microflora and gut health response to histamine ingestion.*
  • Optimal Electrolyte Electrolytes are key for hydration and for supporting the absorption of nutrients into cells, as well as supporting lost electrolytes that occur during cell division.*
  • Optimal PC Contains phosphatidylcholine, a nutrient used to build cell walls and support normal histamine release and regulation.*
  • Optimal Liposomal Vitamin C Vitamin C is needed for optimal histamine response and DAO production. This optimally-absorbed vitamin C formula is one of our best sellers.*


Serving Size: 1 Capsule
Servings Per Container: 30 / 90

Vitamin C (as ascorbyl palmitate)10 mg 11%
DAO2TM porcine kidney extract (Diamine Oxidase Activity 10,000 HDU)4.2 mg**
**Daily Value (DV) not established.

Other Ingredients: Microcrystalline cellulose, vegetarian capsule (hypromellose, water, and gellan gum), and ascorbyl palmitate.
DAO2TM is a licensed trademark of Diem Direct, LLC used with permission.

1. Who is Histamine Block intended for?

Histamine Block is intended for those who experience sensitivity to histamine due to intake of excess histamine from non-allergenic food sources.

Excess histamine can be problematic, resulting in sensitivity or intolerance, digestive concerns, allergies, and more. DAO is clinically tested to break down food-derived histamine in the digestive tract, making it easier to tolerate histamine-rich foods. Histamine block does not reduce reaction to true allergies or IgE immune-driven responses.*

The purpose of Histamine Block is to break down histamine in foods with high histamine content (does not reduce reaction to allergies or IgE immune-driven responses). For additional defense against ingested histamines, try ProBiota HistaminX.*

Always talk to your doctor before considering the use of this product, especially if you have health conditions or diseases that need to be addressed or are pregnant or breastfeeding.

2. How do I take Histamine Block?

Take 1 to 2 capsules no more than 15 minutes before the consumption of histamine-rich foods or drinks, or as directed by your healthcare provider. Do not take Histamine Block and knowingly eat foods you are allergic to—it will not prevent allergic reactions.

3. What is the reasoning for each ingredient in Histamine Block?

Vitamin C Assists DAO in breaking down food-derived histamine in the digestive tract.*
DAO (diamine oxidase) Breaks down food-derived histamine in the digestive tract.*

Other ingredients found in this product include:

  • Microcrystalline cellulose: Structure of capsule.
  • vegetable capsule (hypromellose, water, and gellan gum)
  • ascorbyl palmitate

4. What are the ingredients in Histamine Block derived from?

  • Diamine oxidase is derived from porcine (pig) protein concentrate.
  • Vitamin C is from non-GMO corn.

5. Does Histamine Block contain gluten, soy, or grains?

This product does not contain any gluten or soy ingredients, however, the final product is not tested to be confirmed as gluten-free or soy-free. It contains vitamin C, a product derived from corn, but due to processing, it is considered to be non-allergenic.

6. Is Histamine Block free from GMOs?

We expect this product to be free from genetically modified ingredients, however, the final product is not tested.

7. Is Histamine Block vegetarian/vegan?

This product is not vegetarian or vegan because the DAO (diamine oxidase) is from porcine (pig) sources.

8. What are the possible interactions or side effects of using Histamine Block?

Possible side effects of this supplement include:

  • Feeling shaky
  • Feeling flushed
  • Stomach upset
  • Nausea

These symptoms are mild and rare.

If you believe that you are experiencing any adverse reactions, please see your healthcare professional immediately and discontinue use. Each individual may react differently to any product or supplement. We always recommend that you consult with your healthcare professional prior to considering the use of this or any supplement, especially when pregnant or breastfeeding.

Learning Center Find product FAQ and more! Click here.
Delivery Method Vegetarian Capsule
Storage Keep tightly closed in a cool, dry place out of reach by children.
Age Suitability Adult
Manufactured In USA
Case Quantity 24
Dimensions (in.) Length: 2.00 / Width: 2.00 / Height: 3.75
Return Policy Learn more about our Return Policy.

We are not able to publish reviews that reflect atypical results or suggest that any product can diagnose, treat, cure, or prevent any disease, disorder, or chronic health condition. Please be mindful of these restrictions as you leave your review and thank you for all your feedback!

average rating 4.7 out of 5
Based on 343 reviews
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96% of reviewers would recommend this product to a friend
343 Reviews
Reviewed by Ariel M., from United States
Verified Buyer
I recommend this product
Rated 4 out of 5
Review posted

Hard to tell

I think my issues are just more difficult than some others perhaps. I get bad headaches/migraines when I eat certain kinds of foods nightshades, mushrooms, sugar/sweeteners and wine. I honestly don’t know if the histamine blocker is helping. I’m taking it along with the SulfiteX. I have had some but mostly minimal good results when I take those 2 products when I eat the offending foods. I actually haven’t tried with wine yet since I haven’t had any in the house for so long and forget to buy it to test it, lol. I’m wondering if I should try taking more than one of the Histamine Block capsules? So I would recommend this product to other people, I’m just not sure it’s working for me yet.

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Reviewed by Angela, from United States
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

highly recommended!!

If you have histamine intolerance, you should try. It really works!

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Reviewed by Sean K., from United States
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Histamine Block

It’s a miracle that saved my diet. I take it before every meal. Whenever I run out, my life is very different.

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