I am heterozygous A1298C, along with likely many other relevant SNPs. I tried the Methylated B12 and Folate many times under a controlled test run and concluded that I cannot tolerate Methylated supplements very well. The most obvious symptoms were aggravation and irritation for no other apparent reasons. Per Dr. Bens recommendations and other reason I have now tried 2 test runs of Hydroxo B12 paired with Folinic Acid (Folate) and PROBLEM SOLVED. No random aggression or irritation and energy levels significantly more stable. My diet/supplements/lifestyle choices are very controlled, as well. Thanks Seeking Health and Dr. Ben.
PS: Consider the Strategene Test. It's on sale and I promise will be worth every penny. I printed out my entire report and study it every week.
In a day and age where the people who should be looking out for us are actively NOT, its up to US and people we can trust to lead us toward healing our bodies and being the best we can be.