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Optimal Liposomal L-5-MTHF

30 Servings

This product is unavailable for sale at this time. We do not have an ETA for when this product will be available, but we are diligently working with our manufacturers for best course of action. Consider our L-5-MTHF Lozenges or L-5-MTHF Capsules for an alternate source of methylfolate.

Key Benefits and Actions*

  • Soy-free liposomal format may help support optimal nutrient absorption
  • Provides an active, bioavailable form of folate
  • May help support healthy methylation processes
  • May play a role in healthy DNA/RNA synthesis
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Availability: Out of stock

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Full 30-Day Returns, Guaranteed.

Our return policy covers full refunds or replacements on items within 30 days of purchase.


Suitable for Vegans and Vegetarians

Free of:

Dairy, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat

Optimal Liposomal L-5-MTHF by Seeking Health provides 1,000 mcg of folate (as L-5-MTHF, or methylfolate) per serving. Folate is a water-soluble B vitamin that occurs naturally in food, such as leafy green vegetables, citrus fruits, dried beans, and peas. The methylated form, L-5-methylfolate (L-5-MTHF) requires no additional metabolic steps to be used by the body, and is often the preferred choice for those with absorption or metabolic defects. L-5-MTHF efficiently supports methylation, DNA biosynthesis, homocysteine metabolism, and nervous system function. L-5-MTHF is easily absorbed and used by cells. It is the predominant folate in circulation and the only form of folate that can cross the blood-brain barrier.*

Optimal Liposomal L-5-MTHF utilizes a unique liposomal delivery method to facilitate optimal absorption of our high-potency active folate. A liposome is a tiny phospholipid vesicle that mimics the body’s cell structure. Liposomes may be better absorbed across cell membranes in a way that is not possible for ordinary water-soluble or fat-soluble nutrients. Our liposomes are composed of non-hydrogenated phospholipids, derived from GMO-free sunflower oil. This is a soy free product.*

For a convenient capsule format providing 1,000 mcg of methylfolate, try our L-5-MTHF Capsules. Or, for those who have trouble swallowing capsules, consider our L-5-MTHF Lozenges. Those who are sensitive to methylated B vitamins might consider our Folinic Acid Capsules or Lozenges for a well-absorbed alternative to L-5-MTHF and synthetic folic acid.*

Suggested Use

Gently shake before use. Place 2 ml (1/2 tsp or about 40 drops) into a glass of juice or water and take by mouth. May also place directly into the mouth and swallow. Use as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Consult with a healthcare professional before use if you are using antibiotics or other medications.

Serving Size: 1/2 tsp or approx. 40 drops (2 ml)
Servings Per Container: Approx. 30

Supplement Facts

Folate (as L-5-Methylfolate) 1000 mcg 250%
Phosphatidylcholine and Phosphatidylethanolamine Complex (from non-GMO sunflower oil) 200 mg **
% DV (Daily Value) based on standard 2,000 calorie daily intake
**Daily Value not established

Other Ingredients: Purified water, glycerin, natural flavors and potassium sorbate (0.1% to prevent spoilage). Natural flavors are a vanilla, lemon and lime blend.

Additional Info
Additional Info
Learning Center Find product FAQ and more! Click here.
Cost Per Serving $0.93
Delivery Method Liposomal
Storage Store in a cool, dry place away from direct sunlight. Refrigerate after opening or use within 40 days of opening for maximum potency. Keep out of reach of children.
Suggested Shipping Method Ice Pack not required. If shipping during unusually warm weather, you may choose to add an ice pack for $2.95. If shipping with an ice pack, consider using overnight or 2-day shipping.
Age Suitability Adult
Manufactured In USA
Case Quantity 72
Dimensions (in.) Length: 1.5 / Width: 1.5 / Height: 4.5
Weight (lb.) 0.3000
Barcode 798295548740
Return Policy 30 Day Returns ― Learn more about our Return Policy.
Customer Reviews (9)
Please stock the liquid again soon!
Please make the liquid form available again soon!! I have to take small amounts at a time and the liquid form is the most accurate way of dosing for me. Review by Wendy (Posted on 1/31/2019)
I love this product
This is a wonderful product. I have tried several other brands and formulations of folate that upset my stomach and did not work as well for me. I have not had this problem with Seeking Health brand folate and it helps improve my energy levels throughout the day. Unfortunately, I have been feeling more fatigued while waiting on this product to be restocked. I hope this great product will become available for purchase again very soon! Review by Megan (Posted on 12/9/2018)
Seems to work well, easy to take
Haven’t yet had blood work to determine effectiveness but I feel good. No taste I can determine. Review by Liz (Posted on 12/8/2018)
So thankful for this product!
I’m so glad I found this! I have a hard time with methyl donors. So I take the optimal multi minus one. Working with my doctor now to try to add some methylfolate and I love that I can slowly increase my amount with this! I’m starting with just a few drops and then I’ll slowly add over time without having to divide small pills. I love it!! Review by Julie (Posted on 10/26/2018)
Great folate!
I love this folate, it is so effective and helps my family feel and function better. Review by Stephanie (Posted on 2/26/2018)
Very effective
More potent than an equal dose of Quatrefolic powder and much easier to administer to my kid who can't swallow pills yet. Great product! Review by Stephanie (Posted on 1/26/2018)
Kid friendly
Kid friendly for an MTHFR kiddo who can't yet swallow pills. Good flavor and amazingly much more effective than an equal dose of quatrefolic powder mixed into something! Review by James (Posted on 9/30/2017)
Great quality & effectiveness
When I stopped taking this product I noticed a significant drop in my energy! Review by Oren J (Posted on 9/3/2015)
easy to adjust dose
I like this product because it is so easy to accurately adjust my dose. Review by AMY E (Posted on 11/9/2014)
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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