Histamine Block

Rated 4.8 out of 5
19 Reviews

List price: $

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Key Benefits and Actions*

  • May help support digestion of food-derived histamine in the digestive tract
  • Enhances the presence of diamine oxidase (enzyme) in the digestive tract
  • Patented material with optimized stability
  • May help support normal inflammatory responses in the digestive tract

Histamine Block by Seeking Health contains a patented enzyme formula providing 10,000 HDU of diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine - per capsule. Histamine is known as a biogenic amine, an organic nitrogen compound, involved in certain immune responses and found in mast cells. It may be involved in regulating healthy function in the GI tract as well as the nervous system. Histamine also plays an important role in triggering the body’s normal inflammatory response.

An excess of histamine can be problematic, however, leading to histamine sensitivity/intolerance, digestive concerns, allergies and more. Individual sensitivity to histamine varies, and some individuals may be more reactive to histamines and other biogenic amines in foods. Diamine oxidase (DAO) has been clinically tested and found to break down food-derived histamine in the digestive tract. DAO is not absorbed and does not have systemic activity. Histamine Block does not manage or address antibody-related or IgE-related food allergies.*

To help maintain your body's natural first line of defense against ingested histamine - your gut - try ProBiota HistaminX.


NOT Suitable for Vegans and Vegetarians



Free of:

Milk, Egg, Fish, Tree Nuts, Peanuts, Wheat, Soy, Gluten, Artificial Colors

Suggested Use

Take 1 capsule no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient. Histamine Block is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. DAO is not absorbed and does not have systemic activity. Histamine Block does not manage or address antibody-related or IgE-related food allergies.

Serving Size: 1 Capsule
Servings Per Container: 30 or 90

Vitamin C (ascorbic acid)10 mg11%
Diamine Oxidase (from porcine kidney protein concentrate)4.2 mg (10,000 HDU)**
**Daily Value (DV) not established.

Other Ingredients: Microcrystalline cellulose (plant fiber), vegetable capsule (hypromellose and water), sucrose, rice starch, shellac, hydroxypropylcellulose, crospovidone, hydrated magnesium silicate, sodium carboxymethylcellulose, and glycerol.

1. Who is Histamine Block intended for?

Histamine Block is intended for those who experience sensitivity to histamine due to intake of excess histamine from non-allergenic food sources.

Excess histamine can be problematic, resulting in sensitivity or intolerance, digestive concerns, allergies, and more. DAO is clinically tested to break down food-derived histamine in the digestive tract, making it easier to tolerate histamine-rich foods. Histamine block does not reduce reaction to true allergies or IgE immune-driven responses.*

The purpose of Histamine Block is to break down histamine in foods with high histamine content (does not reduce reaction to allergies or IgE immune-driven responses). For additional defense against ingested histamines, try ProBiota HistaminX.*

Always talk to your doctor before considering the use of this product, especially if you have health conditions or diseases that need to be addressed or are pregnant or breastfeeding.

2. How do I take Histamine Block?

Take 1 to 2 capsules no more than 15 minutes before the consumption of histamine-rich foods or drinks, or as directed by your healthcare provider. Do not take Histamine Block and knowingly eat foods you are allergic to—it will not prevent allergic reactions.

3. What is the reasoning for each ingredient in Histamine Block?

Vitamin C Assists DAO in breaking down food-derived histamine in the digestive tract.*
DAO (diamine oxidase) Breaks down food-derived histamine in the digestive tract.*

Other ingredients found in this product include:

  • Microcrystalline cellulose: Structure of capsule.
  • HPMC: Capsule.
  • Sucrose: Natural preservative.
  • Rice starch: Protective carrier for DAO.
  • Shellac: Stabilizer.
  • Hydroxypropylcellulose: Structure of capsule.
  • Crospovidone: Dispersal aid.
  • Hydrated magnesium silicate: Anti-caking agent.
  • Sodium carboxymethylcellulose: Carrier for disintegration and dispersal.
  • Glycerol: Emulsifier and stabilizer; helps shuttle DAO into cells.

4. What are the ingredients in Histamine Block derived from?

  • Diamine oxidase is derived from porcine (pig) protein concentrate.
  • Vitamin C is from non-GMO corn.

5. Does Histamine Block contain gluten, soy, or grains?

This product does not contain any gluten or soy ingredients, however, the final product is not tested to be confirmed as gluten-free or soy-free. It contains vitamin C, a product derived from corn, but due to processing, it is considered to be non-allergenic.

6. Is Histamine Block free from GMOs?

We expect this product to be free from genetically modified ingredients, however, the final product is not tested.

7. Is Histamine Block vegetarian/vegan?

This product is not vegetarian or vegan because the DAO (diamine oxidase) is from porcine (pig) sources.

8. What are the possible interactions or side effects of using Histamine Block?

Possible side effects of this supplement include:

  • Feeling shaky
  • Feeling flushed
  • Stomach upset
  • Nausea

These symptoms are mild and rare.

If you believe that you are experiencing any adverse reactions, please see your healthcare professional immediately and discontinue use. Each individual may react differently to any product or supplement. We always recommend that you consult with your healthcare professional prior to considering the use of this or any supplement, especially when pregnant or breastfeeding.

Learning Center Find product FAQ and more! Click here.
Delivery Method Vegetarian Capsule
Storage Keep tightly closed in a cool, dry place out of reach by children.
Age Suitability Adult
Manufactured In USA
Case Quantity 24
Dimensions (in.) Length: 2.00 / Width: 2.00 / Height: 3.75
Return Policy Learn more about our Return Policy.
average rating 4.8 out of 5
Based on 19 reviews
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95% of reviewers would recommend this product to a friend
19 Reviews
Rated 5 out of 5
Review posted


This stuff is a lifesaver. Best help for food allergies/histamine intolerance

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Rated 5 out of 5
Review posted

Excellent Product for Histamine Intolerance!

This product keeps my issues with histamine intolerance under control. No more break outs! I also use their ProBiota HistaminX as it is the only probiotic that my sensitive system can tolerate. Seeking Health's customer service is exemplary and I completely trust the quality of their products. Thank you Seeking Health for improving my life!

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Rated 5 out of 5
Review posted

Family Lifesaver

I had serious histamine issues, and my brother had worst than me I ordered these, and my health got a lot better. I gave my brother some to use over the holidays, and he hasn't stop raiding my bottle and bugging me tto order him a bottle of miracle pills.

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Rated 5 out of 5
Review posted

Highly recommended!!

This product helps my histamine intolerance! I can't eat without this product! Thank you so much!

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Rated 5 out of 5
Review posted

It is helping!

My mom had a horrible reaction for a few weeks due to histamine issues and I got this for her and this really helped!

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