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For limited time, enjoy 20% off Multivitamin Sensitive. While supplies last. Automatic discount applied at checkout.
For limited time, enjoy 20% off Multivitamin Sensitive. While supplies last. Automatic discount applied at checkout.

Histamine Block Plus

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  • Supports a healthy seasonal histamine response, outdoors and indoors
  • Provides nutrients needed to support healthy histamine breakdown
  • You will notice it works quite quickly
This formula contains niacin. When taken on an empty stomach, a healthy response to niacin supplementation may include mild blushing, warming, or tingling of the skin. See below for more details.

Who Needs Histamine Block Plus

Histamine issues are front and center in your life. It seems you cannot get a handle on them.

You’ve realized that you need histamine support beyond just limiting high histamine food and drinks.

Here are some common scenarios which may resonate with you:

  • You love cats and dogs but your body doesn’t let you love them.
  • Some months of the year, you take a step outside and you find yourself sneezing right away. Mowing the lawn or going for a walk outside can really set you off.

Histamine Block Plus contains histamine-processing nutrients which support total body histamine breakdown.

If you relate to one or more of the following statements, then Histamine Block Plus may be helpful for you in supporting healthy histamine levels:

The synergistic blend of nutrients found in Histamine Block Plus supports healthy histamine metabolism. It also supports the body’s normal breakdown of histamine’s toxic byproducts.

Customer Review

Histamine Block Plus

My 10 year old son suffers from seasonal discomfort. Since starting him on Histamine Block Plus, he can now play outdoors all day and fall asleep easily. My husband has had support from it as well since taking these, too! I love how you don’t have to take it everyday as well! Definitely recommended for anyone experiencing seasonal discomfort! - Holly

Key Ingredients In Histamine Block Plus

  • DAO2TM (Diamine oxidase): A patented, porcine-derived enzyme. DAO is the enzyme responsible for breaking down histamine in the digestive tract
  • Zinc, Vitamins B1 & B3: Nutrient cofactors for aldehyde metabolism and the ALDH enzyme
  • SAMe: A cofactor for the HNMT enzyme that breaks down histamine throughout the body
  • Alpha Keto-Glutarate: Supports the normal breakdown of ammonia, a toxic byproduct of histamine metabolism
  • PQQ: supports normal breakdown of hydrogen peroxide and aldehydes
  • Vitamin C: stabilizes mast cells to support healthy histamine release
  • Vitamin B6: a cofactor for the DAO enzyme and supports healthy ammonia levels
  • Vitamin B5 (pantothenic acid): a cofactor for the NAT2 enzyme, which metabolizes histamine to acetyl histamine and eliminates it in the urine

Why Histamine Block Plus Works

In order for your body to have healthy histamine levels, you have to provide very specific nutrients. If you are lacking in even just one nutrient, your histamine levels will be problematic for you.

This is likely why histamine intolerance is such a common issue. It just takes one nutrient deficiency.

Here's why.

Histamine is a compound that requires destruction by multiple enzymes. These enzymes require specific nutrients. Think of it like an assembly line. If one worker gets overwhelmed, or doesn't have the right tools for the job, everything gets backed up.

Histamine Block Plus is the first, and likely only, supplement which supports all the histamine breakdown enzymes in your body. All of them. There are five enzymes which break apart histamine and eliminate it from your body. As mentioned before, you have to have ALL 5 enzymes working together simultaneously. If you don’t, you will not achieve healthy histamine levels.

Here are your five histamine breakdown enzymes:

  1. HNMT: this requires SAMe to initiate the first step of histamine breakdown into methylhistamine. HNMT is found heavily in your brain, uterus and liver.
  2. MAOA and MAOB: these two enzymes both require vitamin B2. These two enzymes process the methylhistamine made by HNMT.
  3. ALDH: this enzyme requires zinc, niacin and vitamin B1. This enzyme processes the compounds made by your MAOA, MAOB and DAO enzymes.
  4. DAO: this enzyme requires copper and vitamin B6. This enzyme processes histamine found in the digestive tract, placenta, bladder and many other areas.



It's not that easy.

As these enzymes work in breaking down histamine, they create the toxic compounds of ammonia, hydrogen peroxide, and acetaldehyde. These compounds must be broken down by additional enzymes. These enzymes require alpha keto-glutarate, thiamine and PQQ.

Next time you want to support healthy levels of histamine, and the elimination of the toxic byproducts, take 2 capsules of Histamine Block Plus anytime you need it - day or night. You will notice that it acts quite quickly.

Histamine Block Plus
Supplement Facts

Serving Size: 2 Capsules
Servings Per Container: 30

Vitamin C (as ascorbic acid) 100 mg 111%
Thiamine (as thiamine hydrochloride) 20 mg 1,667%
Riboflavin (as riboflavin 5'-phosphate sodium) 10 mg 769%
Niacin (as nicotinic acid) 25 mg 156%
Vitamin B6 (as pyridoxal 5'-phosphate) 7 mg 412%
Pantothenic Acid (as d-calcium pantothenate) 10 mg 200%
Magnesium (as DiMagnesium Malate§) 50 mg 12%
Zinc (as zinc gluconate) 5 mg 45%
Copper (as copper gluconate) 0.5 mg 56%
Alpha-Ketoglutaric Acid 150 mg **
SAMe (as disulfate ptoluensulfonate) 100 mg **
PQQ (as LifePQQTM pyrroloquinoline quinone disodium salt) 7 mg **
DAO2TM porcine kidney extract (Diamine Oxidase Activity 5,000 HDU) 2.1 mg **
**Daily Value (DV) not established.

Other Ingredients: Vegetarian capsule (hypromellose, water, and gellan gum), microcrystalline cellulose, ascorbyl palmitate, and silica.
§Albion®, TRAACS® and the Albion Gold Medallion design are registered trademarks of Albion Laboratories, Inc.
DAO2TM is a licensed trademark of Diem Direct, LLC used with permission.

    NOT Suitable for Vegetarians or Vegans
  • Delivery Method: Capsules
  • How To Store: Keep tightly closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use Histamine Block Plus

Suggested Use

As needed, take 2 capsules anytime of day or night. If you’re sensitive to niacin, take with food to minimize the niacin flush. Use before bed to support healthy sleep onset. Use as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient. Histamine Block Plus is not effective for symptoms of immune-related (antibody- or IgE related) food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease.

Niacin Flushing: This formula contains niacin. When taken on an empty stomach, a healthy response to niacin supplementation may include mild blushing, warming, or tingling of the skin. This can appear on the ears, face, arms, torso, or occasionally on the legs. Commonly referred to as a "niacin flush", this harmless response normally dissipates within an hour. It is related to niacin's role in vasodilation (widening of blood vessels). Vasodilation leads to better circulation, capillary flushing, and increased blood flow to the surface of the skin. To minimize or prevent flushing, consider taking this supplement with food or in divided doses.

FAQs for Histamine Block Plus

What is the purpose of each ingredient in Histamine Block Plus?

Ingredients Purpose
Vitamin C Supports healthy DAO production, normal histamine breakdown, and normal inflammatory processes
Thiamine Is often depleted in the presence of high aldehyde levels and other histamine byproducts
Niacin Plays a role in increasing the activity of the ALDH enzyme family to support the normal regulation of acetaldehyde concentrations
Vitamin B6 Works with DAO to help support the normal breakdown of histamine
Pantothenic Acid Cofactor for the NAT2 enzyme, which metabolizes histamine to acetylhistamine
Magnesium Supports normal glutamate response from ammonia release. Ammonia is released from histamine metabolism
Zinc Cofactor for the ALDH enzyme family
Copper Cofactor for the DAO enzyme
Alpha-Ketoglutaric Acid Supports normal ammonia breakdown, which is created from histamine metabolism
SAMe Cofactor for the HNMT enzyme, which is a major enzyme in histamine breakdown
PQQ Supports healthy oxidative stress responses
DAO (porcine extract) The enzyme that supports healthy breakdown of histamine from food

Why is Histamine Block Plus not suitable for vegans or vegetarians?

Histamine Block Plus contains porcine-derived ingredients.

Which histamine product is right for me?

Check out this Histamine Supplement Comparison Chart..

If you have a question that's not addressed
here, see all frequently asked questions.


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What our customers say

Real reviews from real customers.

Rated 4.8 out of 5 stars
Based on 184 reviews
Total 5 star reviews: 163 Total 4 star reviews: 9 Total 3 star reviews: 6 Total 2 star reviews: 1 Total 1 star reviews: 5
95%would recommend this product
184 reviews
  • M
    Verified Reviewer
    I recommend this product
    Rated 5 out of 5 stars
    2 weeks ago
    My "must-have" for seasonal and environmental sensitivities

    We are new to the Utah Valley area and my sensitivities this past spring/early summer really needed support. The air quality in the valley is quite poor, and my body just struggled, especially on the heels of a spring cold I caught. Many people here use fragrances indoors. I ordered the histamine block plus for support, hoping for something to help what my body was experiencing, and this supplement (in conjunction with halotherapy for bronchitis) got me feeling well. I personally see very quick support for symptoms - within 20 minutes I can breathe well, my eyes and sinuses feel clear.

  • TM
    Teri M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    4 weeks ago
    Very helpful!

    I suffer from severe histamine intolerance and am thankful for the Histamine Block Plus that I take every night at bedtime. Seems to be helping me balance my histamine better.

  • SW Profile picture for Shannon W.
    Shannon W.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    It works!

    Oh my goodness! It works! Histamine sensitives kept me awake. I tried this and voilà! Sleep! Blessed sleep! Hallelujah!

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These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.