Skip to content
Free Shipping on All Orders, No Minimum!*
Free Shipping on All Orders, No Minimum!*

Histamine Digest

Rated 4.8 out of 5 stars
637 Reviews

Histamine Digest

Original price $32.95 - Original price $407.76
Original price
You save: $$$ (%)
$32.95 - $407.76
Current price
You save: $$$ (%)
  • Breaks down histamine naturally using the patented DAO2 TM enzyme
  • Be confident and relaxed when eating and drinking
  • Results are fast acting
COMING SOON - Histamine Block will have a new name, Histamine Digest!

Who Needs Histamine Digest

Can’t digest histamine?

Histamine Block digests histamine when you cannot.

Now you can eat and drink with confidence.

If you select two or or more of the following statements below, then Histamine Block may be helpful for you in supporting the digestion of high histamine:

  • Alcohol, especially red wine or champagne
  • Aged cheeses (eg. Parmesan, Gouda, Swiss, Cheddar)
  • Aged meats (eg. salami, pepperoni, canned meat, sausages, jerky)
  • Fish
  • Tomatoes
  • Sausages
  • Orange juice
  • Pineapple juice
  • Very ripe fruit (eg. strawberries, bananas)
  • Avocados
  • Sauerkraut, Kimchi
  • Balsamic vinegar
  • Kombucha
  • Leftovers
  • Headaches
  • Hives
  • Frequent inappropriate fatigue
  • Difficulty falling asleep
  • Loose stools
  • Bloating, gas
  • Stomach discomfort
  • Bladder discomfort
  • Nausea or pukey
  • Frequent peeing.
  • Waking up to pee at night
  • Ringing in the ears or fluid
  • Bedwetting
  • Heart palpitations or faster heart beat
  • Rashes, itchy skin or eczema
  • Sweating, flushing, red spots on skin or just feel hotter
  • Sneezing or runny nose
  • Menstrual cramps
  • Irritability
  • Anxiousness
  • Nose bleeds

How many did you check from the quiz above?

If you checked two or more, Histamine Block is highly recommended.

Customer Review

Amazing Products

This product has been a game changer for us. My daughter can enjoy food so much more and road trips are no longer nearly as stressful. We take the Histamine Block everywhere! ~ Esquibel F.

Key Ingredients In Histamine Digest

  • DAO2 TM (Diamine oxidase): This patented enzyme supports the healthy breakdown of histamine in many areas of your body - especially the small intestine, colon, placenta, kidney, appendix, testis and prostate.
  • Vitamin C: Plays a crucial role in DAO production and a healthy inflammatory response

Why Histamine Digest Works

You have a gene called DAO. This gene makes an enzyme that has one job to do. This one job is to break down histamine found in various parts of your body.

The problem is many people do not have a healthy, functioning DAO enzyme for a variety of reasons.

This is why you may need Histamine Digest.

Histamine Digest provides you with the patented, lab tested and pure DAO enzyme called DAO2.

Essentially, after you swallow the small capsule of Histamine Digest, the capsule breaks open in about a minute and releases the DAO enzyme in your small intestine. The released DAO enzyme immediately starts breaking down histamine for you so your body doesn’t have to.

If you do not have enough DAO enzyme to break down histamine from any of these sources, you’ll have symptoms.

The symptoms you experience depend on where your DAO enzyme isn’t functioning very well. Your DAO enzyme, when healthy, is naturally found in high concentrations in specific areas of your body:

  • Small intestine
  • Colon (large intestine)
  • Appendix
  • Kidney
  • Placenta
  • Testicles
  • Prostate

Your DAO enzyme works on breaking histamine down from these main sources of histamine:

  1. Food and drink
  2. Your gut’s immune system
  3. Your microbiome

The primary reason why histamine can affect your entire body is because of leaky gut. Leaky gut allows histamine from these three sources to leak out from your small, or large intestine, and get absorbed into the rest of your body. When this happens, you will struggle from something called histamine intolerance.

Histamine intolerance occurs when your body cannot break down histamine fast enough. Essentially, you’ve exceeded your DAO enzyme’s capacity to break down histamine.

This is why histamine intolerance is so frustratingly difficult for people. Some days you are fine, feeling great, and symptom-free. Then, when something increases your histamine levels more than your DAO enzyme can break down, you get symptoms of histamine intolerance.

Histamine intolerance is not an allergic response. Histamine intolerance is very similar to lactose intolerance. Both of these intolerances are frustrating, embarrassing at times, and cause numerous problematic symptoms. However, they will not send you to the hospital.

By using Histamine Digest, you’ll once again support healthy levels of the DAO enzyme. By doing so, you may be free of histamine intolerance!

Important note: Histamine Digest is very effective for providing the DAO enzyme immediately to support your digestive system.

Histamine Digest is known as a palliative supplement. It helps you feel great but it doesn’t solve the underlying problem.

Ultimately, you want your body’s DAO enzyme to function well on its own. This takes time to figure out how to heal your digestive system, restore your microbiome and balance your immune system. Work with a naturopathic physician or integrative health professional to help you work through these areas.

Experience relief now. Use Histamine Digest so you can immediately enjoy feeling healthy, instead of struggling, when you consume foods or drinks high in histamine. Over time, as you work on healing your gut, restoring your healthy microbiome and balancing your immune system, you’ll need less Histamine Digest.

Histamine Digest
Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 30 / 90

Vitamin C (as ascorbyl palmitate)10 mg 11%
DAO2TM porcine kidney extract (Diamine Oxidase Activity 10,000 HDU)4.2 mg**
**Daily Value (DV) not established.

Other Ingredients: Microcrystalline cellulose, vegetarian capsule (hypromellose, water, and gellan gum), and ascorbyl palmitate.
DAO2TM is a licensed trademark of Diem Direct, LLC used with permission.

    NOT Suitable for Vegetarians or Vegans
  • Delivery Method: Capsules
  • How To Store: Keep tightly closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use Histamine Digest

When taken with meals, Histamine Digest helps break down histamine found in foods and drinks. Histamine will be at a healthy level which helps eliminate feelings related to histamine intolerance.†‡

When taken on an empty stomach, Histamine Digest helps break down histamine produced from the microbiome or your gut’s immune system. It’s a good idea to try taking Histamine Digest on an empty stomach to see if you feel better. If you do feel better, then you may have an unhealthy microbiome, or an active gut immune system, that’s producing high amounts of histamine.

Histamine Digest may support healthy levels of histamine within the small intestine, colon, kidneys, appendix, placenta, prostate, or testicles. This is very important as unhealthy levels of histamine within these areas contribute to problems locally or throughout the body.

Children 4 years of age and older may use Histamine Digest. You may need to open the small capsule and mix in a bite of applesauce if they cannot swallow the small capsule.

Breastfeeding women may use Histamine Digest. Pregnant women please consult with your healthcare provider. High histamine levels are associated with problematic pregnancies. Histamine Digest may be prescribed by some health providers to support a healthy pregnancy.

Suggested Use

Take 1 capsule, as needed, just prior to consuming high histamine foods or drinks. Or, take away from food if wanting to support healthy histamine levels in the digestive tract.

Use as directed by your healthcare professional.

Do not take Histamine Digest and knowingly eat foods you are allergic to—it will not prevent allergic reactions.


Histamine Digest is not effective for immune-related food allergies, such as peanuts, shellfish, gluten intolerance or celiac disease. Histamine Digest does not manage or address antibody-related or IgE-related food allergies.

Pregnant women should consult their healthcare practitioner prior to use.

This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient.

How to Enhance Histamine Digest


Implement a Low-Histamine Diet

This involves removing foods from your diet known to cause adverse reactions. A histamine-free diet excludes aged cheeses, cured meats like salami, red wine, avocado, eggplant, tomatoes, fermented foods, and other foods with high histamine levels. Reducing dietary histamine reduces total body histamine, which supports the effectiveness of this product. An elimination diet can be helpful when working to identify food intolerance.


Pairs Well With

ProBiota HistaminX, provides select histamine balancing probiotic strains which support healthy histamine levels. Optimal GI Plus, to support healthy restoration of your gut, bladder and uterine lining. Digestive Intensive, to support healthy digestion, and absorption, of fats, carbohydrates and protein.


Clean Your Genes

After years of suffering from unexplainable health issues, Dr. Ben Lynch, ND discovered the root cause - "dirty" genes. In his best-selling book, Dirty Genes, Dr. Ben Lynch describes the steps you can take to promote optimal epigenetic health. Ready to get started? Click here to take the Dirty Genes Quiz to find which of your genes are dirty!

Why Choose Seeking Health

Here at Seeking Health, we are committed to providing you the best in bioavailable supplements, methylation support, prenatal vitamins, genetic analysis tools, and more.

We strive to go above and beyond the average supplement company, which is why we allocate significant resources to testing all of our supplements for purity, potency, and label claims.

  • Third-party tested for heavy
    metals, microbials, and potency
  • Scientifically formulated by Dr. Ben Lynch, ND
  • Manufactured in the USA from globally
    sourced ingredients
  • Nutrients in their bioavailable
    forms for optimal absorption
  • cGMP facility registered by NSF International
Purity & Potency Tested & Assured
Scientifically Formulated by Dr. Ben Lynch
Manufactured in the USA from globally sourced ingredients third-party independently tested
Bioavailable Nutrients

FAQs for Histamine Digest

What is the purpose of each ingredient in Histamine Digest?

Ingredients Purpose
Vitamin C Plays a crucial role in DAO production and a healthy inflammatory response
DAO2TM (diamine oxidase) The enzyme that breaks down histamine in various parts of the body - especially the small intestine, colon, placenta, kidney, appendix, testis and prostate.

Why is Histamine Digest not suitable for vegans or vegetarians?

Histamine Digest is not vegetarian or vegan because the DAO (diamine oxidase) is from porcine (pig) sources.

Which histamine product is right for me?

Check out this Histamine Supplement Comparison Chart.

If you have a question that's not addressed
here, see all frequently asked questions.


Do you have Questions
for this Product?


What our customers say

Real reviews from real customers.

Rated 4.8 out of 5 stars
Based on 637 reviews
Total 5 star reviews: 547 Total 4 star reviews: 58 Total 3 star reviews: 14 Total 2 star reviews: 5 Total 1 star reviews: 13
96%would recommend these products
637 reviews
  • K
    Verified Buyer
    Histamine Block
    Histamine Block
    I recommend this product
    Rated 5 out of 5 stars
    42 minutes ago
    Sleep Support

    This supported my healthy sleep when I started taking at night. Great product!!

  • JM
    Jeannine M.
    Verified Buyer
    Histamine Block
    Histamine Block
    I recommend this product
    Rated 5 out of 5 stars
    22 hours ago
    Side-Dish of Support

    It's comforting to have Histamine Block nearby for those meals where the potential for histamine havoc lies in wait.

    Does it completely eliminate the rise of those 'kick-you-in-the-pants' kind of histamine moments - each and every time?

    ~ Well ... no.

    If you go overboard with too many hissy fit foods in one sitting - or persist on challenging your gut to a histamine showdown - you may be disappointed.

    But then again, this unfortunate fact would apply to any product of this type.

    For me, I wouldn't dare go near a dinner plate without Histamine Block.

    ~ Just not worth it. ~

  • M
    Verified Buyer
    Histamine Block
    Histamine Block
    I recommend this product
    Rated 5 out of 5 stars
    This product is great and does work

    This is a good product, but there are instructions do not take more than 15 mins before meals. Other reviews say take right before a meal or with meal. Very different instructions. Which is it? Taking right before you eat is so much easier. The 15 mins before can be difficult and tricky. Sometimes you are just hungry and need/want to eat. And if you go over the 15 mins it is lost in effectiveness. Someone needs to definitely state what is it in terms of effectiveness and timing of this product. It is too expensive to do it wrong. Saying take right before meal is wrong if it needs to be taken 10-15 mins before. Would like an answer on this!e

Reviews LoadedReviews Added
These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.