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Histamine Digest

  • Digests histamine fast using the patented DAO2 TM enzyme.
  • Eat and drink with confidence again!
  • Supports healthy histamine levels in the small intestines, colon, uterus, bladder, prostate and breast milk.

Who Needs Histamine Digest

Can’t digest histamine?

Histamine Digest can do it for you.

Now you can eat and drink with confidence.

Assess each statement below. If you relate to any of them, then Histamine Digest may help you support healthy histamine levels:

  • Alcohol, especially red wine or champagne
  • Aged cheeses (eg. Parmesan, Gouda, Swiss, Cheddar)
  • Aged meats (eg. salami, pepperoni, canned meat, sausages, jerky)
  • Fish
  • Tomatoes
  • Sausages
  • Orange juice
  • Pineapple juice
  • Very ripe fruit (eg. strawberries, bananas)
  • Avocados
  • Sauerkraut, Kimchi
  • Balsamic vinegar
  • Kombucha
  • Leftovers
  • Headaches
  • Hives
  • Frequent inappropriate fatigue
  • Difficulty falling asleep
  • Loose stools
  • Bloating, gas
  • Stomach discomfort
  • Bladder discomfort
  • Nausea or pukey
  • Frequent peeing.
  • Waking up to pee at night
  • Ringing in the ears or fluid
  • Bedwetting
  • Heart palpitations or faster heart beat
  • Rashes, itchy skin or eczema
  • Sweating, flushing, red spots on skin or just feel hotter
  • Sneezing or runny nose
  • Menstrual cramps
  • Irritability
  • Anxiousness
  • Nose bleeds

If a number of those resonated with you, then Histamine Digest is something that you should seriously consider.

If none of the statements above resonated with you, then Histamine Digest is not something you need currently.

Alternatively, consider Histamine Block Plus or ProBiota HistaminX.

Customer Review

Amazing Products

This product has been a game changer for us. My daughter can enjoy food so much more and road trips are no longer nearly as stressful. We take the Histamine Block everywhere! ~ Esquibel F.

Key Ingredients In Histamine Digest

  • DAO2 TM (Diamine oxidase): This patented enzyme supports the healthy breakdown of histamine in many areas of your body - especially the small intestine, colon, placenta, kidney, appendix, testis and prostate.

Why Histamine Digest Works

You have a gene called DAO. This gene makes an enzyme that digests histamine.

Your DAO enzyme is found in various parts of your body in order to maintain healthy levels of histamine.

The problem is many people, and possibly you, do not have a DAO enzyme working very well for a variety of reasons.

This is why you may need Histamine Digest.

Histamine Digest provides you with the patented, lab tested and pure DAO enzyme called DAO2.

After you take a small capsule of Histamine Digest, the capsule breaks open and releases its contents of the DAO enzyme in your small intestine. The released DAO enzyme immediately starts digesting histamine for you so your body doesn’t have to.

Histamine Digest works on digesting histamine from these main sources of histamine:

  1. Food and drink
  2. Your gut’s immune system
  3. Your microbiome

By using Histamine Digest, you’ll once again support healthy levels of the DAO enzyme. By doing so, you may notice fewer symptoms of histamine intolerance!

Histamine Digest
Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 30 / 90

Vitamin C (as ascorbyl palmitate)10 mg 11%
DAO2TM porcine kidney extract (Diamine Oxidase Activity 10,000 HDU)4.2 mg**
**Daily Value (DV) not established.

Other Ingredients: Microcrystalline cellulose, vegetarian capsule (hypromellose, water, and gellan gum), and ascorbyl palmitate.
DAO2TM is a licensed trademark of Diem Direct, LLC used with permission.

    NOT Suitable for Vegetarians or Vegans
  • Delivery Method: Capsules
  • How To Store: Keep tightly closed in a cool, dry place out of reach by children.

Free Of: Corn, Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use Histamine Digest

When taken with meals, Histamine Digest helps break down histamine found in foods and drinks. Histamine will be at a healthy level which helps eliminate feelings related to histamine intolerance.†‡

When taken on an empty stomach, Histamine Digest helps break down histamine produced from the microbiome or your gut’s immune system.

This is a great idea to try: Take 1 capsule of Histamine Digest on an empty stomach to see if you feel better within 30 minutes.

Why would this be useful? High amounts of histamine are produced by an unhealthy microbiome, or an overactive gut immune system.

If you feel better, continue using Histamine Digest on an empty stomach as needed. Histamine Digest supports a healthy balance of histamine in the gut.

Histamine Digest may support healthy levels of histamine within the small intestine, colon, kidneys, uterus, appendix, placenta, prostate, or testicles. This is very important as unhealthy levels of histamine within these areas contribute to problems locally or throughout the body.

Children 4 years of age and older may use Histamine Digest. You may need to open the small capsule and mix in a bite of applesauce if they cannot swallow the small capsule.

Breastfeeding women may use Histamine Digest. Histamine gets absorbed from the gut and into breastmilk. If breastmilk has higher levels of histamine, the breastfeeding baby may experience colic. Infant colic is associated with higher levels of histamine. Support healthy levels of histamine in your breastmilk by taking Histamine Digest.

Pregnant women may use Histamine Digest if approved by their healthcare professional. Occasional nausea and vomiting of pregnancy is associated with high levels of histamine. Levels of histamine in a healthy pregnancy decrease below values found in healthy non-pregnant women. This is because the placenta is designed to produce a lot of the DAO enzyme. However, sometimes the levels of histamine exceed the ability of the placenta’s DAO enzyme to digest histamine.

In some complications of pregnancy, maternal blood histamine levels rise above those associated with a healthy pregnancy. Many of the complications of pregnancy, including preeclampsia, preterm labour, spontaneous abortion and hyperemesis gravidarum, are associated with increased levels of maternal blood histamine. Supporting healthy levels of maternal blood histamine levels during pregnancy, especially during such complications, may be helpful.

Suggested Use

Take 1 capsule, as needed, just prior to consuming high histamine foods or drinks. Or, take away from food if wanting to support healthy histamine levels in the digestive tract.Use as directed by your healthcare professional.

Do not take Histamine Digest and knowingly eat foods you are allergic to—it will not prevent allergic reactions.


Histamine Digest is not effective for immune-related food allergies, such as peanuts, shellfish, gluten intolerance or celiac disease. Histamine Digest does not manage or address antibody-related or IgE-related food allergies.

Pregnant women should consult their healthcare practitioner prior to use.

This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient.

Dr. Lynch's Tips

Important Note:

Histamine Digest is very effective for providing the DAO enzyme immediately to support your digestive system.

Histamine Digest is known as a palliative supplement. It helps you feel great but it doesn't solve the underlying problem.

Ultimately, you want your body’s DAO enzyme to function well on its own. It takes time to figure out how to heal your gut, restore your microbiome and balance your immune system. Work with a naturopathic physician or integrative health professional to help you work through these areas.

It’s possible to experience relief now. Use Histamine Digest so you can immediately enjoy feeling healthy, instead of struggling, when consuming foods or drinks high in histamine.

Over time, as you work on healing your gut, restoring your healthy microbiome and balancing your immune system, you’ll likely need less Histamine Digest to support healthy histamine metabolism.

Change in bowel frequency may occur from using Histamine Digest.

High amounts of histamine in the gut are associated with loose stools or diarrhea. Low amounts of histamine are associated with constipation. Since Histamine Digest supports healthy histamine levels, if one takes too much, it may contribute to harder to pass stools.

If stools become harder to pass, only use Histamine Digest when eating foods or drinks with histamine.

If you continue having harder to pass stools, then stop using Histamine Digest and consume a histamine-containing drink like kombucha. If you now can pass stools normally again, then you know you may have taken too much Histamine Digest. Adjust your use as needed.

Note that your use of Histamine Digest will reduce as you restore a healthy gut lining and a healthy gut microbiome.

This is why it’s highly recommended to use ProBiota HistaminX each evening after dinner. Probiota HistaminX supports a healthy gut microbiome.

FAQs for Histamine Digest

What is the purpose of each ingredient in Histamine Digest?

Ingredients Purpose
Vitamin C Plays a crucial role in DAO production and a healthy inflammatory response
DAO2TM (diamine oxidase) The enzyme that breaks down histamine in various parts of the body - especially the small intestine, colon, placenta, kidney, appendix, testis and prostate.

Why is Histamine Digest not suitable for vegans or vegetarians?

Histamine Digest is not vegetarian or vegan because the DAO (diamine oxidase) is from porcine (pig) sources.

Which histamine product is right for me?

Check out this Histamine Supplement Comparison Chart.

If you have a question that's not addressed
here, see all frequently asked questions.


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What our customers say

Real reviews from real customers.

Rated 4.8 out of 5 stars
Based on 681 reviews
Total 5 star reviews: 587 Total 4 star reviews: 62 Total 3 star reviews: 14 Total 2 star reviews: 5 Total 1 star reviews: 13
96%would recommend these products
681 reviews
  • T
    Verified Reviewer
    Histamine Digest
    Histamine Digest
    I recommend this product
    Rated 5 out of 5 stars
    loved it

    I took the entire bottle and I saw a difference. I was able to eat quite a few things I am sensitive to. I still have some sensitivities but this is supportive. It was worth the buy and I do recommend this.

  • A
    Verified Buyer
    Histamine Digest
    Histamine Digest
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago

    I have a histamine problem so I take this before meals. It really works!

  • AS Profile picture for Ang Seoh logo
    Ang Seoh L.
    Verified Buyer
    Histamine Digest
    Histamine Digest
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    Standby Supplements

    I had to buy this to replace the histamine block plus. To standby for any sensitives at dinner that might affect my sleep.

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These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.