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L-Methylfolate

$19.95
  • Powerful methylation, MTHFR, and homocysteine support
  • Supports healthy cognition and mood
  • Healthy genetic expression support

Who Needs L-Methylfolate

Methylation controls multiple biochemical pathways in your body.

Your genetics, heart health, hormones, sleep, stress, mood, and detoxification depend on healthy methylation.

Where does your body get the methyl groups needed to carry out methylation? Primarily from folates that come from food and intestinal microbes. Food folates must be first converted into an active form before your body can use them.

Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).

Over 50 percent of the population is thought to have a genetic mutation in their MTHFR gene. Thus, they may not be achieving adequate methylfolate levels from food alone.

Because L-5-MTHF bypasses the MTHFR enzyme, it can provide methylation support for those with MTHFR polymorphisms.

Folate (as bioavailable L-methylfolate) is:

  • Easily absorbed and used by cells
  • The predominant form of folate in circulation
  • The only form of folate that can cross the blood-brain barrier
  • Essential for methylation, DNA expression, homocysteine metabolism, and nervous system function

Seeking Health’s L-methylfolate contains 1,700 mcg DFE of methylfolate in the bioavailable form of L-5-methyltetrahydrofolate (L-5-MTHF).

The bioactive form of L-methylfolate (L-5-MTHF) is well-utilized in the methylation cycle. It is often the preferred form for those with methylation, homocysteine, or MTHFR gene mutation concerns.

Mutations in your MTHFR gene can lead to reduced L-methylfolate production and a less functional methylation cycle. Challenges in the methylation cycle are associated with an increased risk for cardiovascular and mood issues, birth defects, and infertility concerns.

Mutations in this gene can also slow your body’s ability to convert folate into its active forms. Thus, a large majority of people may benefit from consuming an L-methylfolate dietary supplement.

The most direct way to support methylation and MTHFR genetic mutations is with L-methylfolate (L-5-MTHF).

Supplementing with bioavailable L-methylfolate supports:

  • Healthy methylation
  • Positive mood
  • Healthy homocysteine levels
  • Nervous system function and development
  • Prevention of neural tube defects during pregnancy
  • Healthy energy production
  • Normal cognitive, memory, and brain function

Get ready for your methylation cycle to fire on all cylinders with Seeking Health’s L-methylfolate!

Customer Review

Wow!

I have no idea why I waited so long in life to use this stuff. I’m so much calmer and life feels so much easier. It’s made such a beautiful difference.

Key Ingredients In L-Methylfolate

  • L-5-MTHF: A superior form of L-methylfolate that readily donates its methyl groups. It aids conversion of the amino acid homocysteine into methionine and supports your entire methylation cycle.

Why L-Methylfolate Works

Folate plays critical roles in methylation. By donating its methyl groups, folate regulates DNA expression and much more. Without sufficient bioavailable folate, your cells cannot effectively express your genes.

The MTHFR gene converts food folates into methyl folates. However, MTHFR variations and environmental or lifestyle stress can slow this gene down. If the MTHFR gene is slowed, MTHFR enzyme function is also slowed. The result can be a debilitating folate deficiency.

The artificial version of folate, folic acid, is often prescribed to folate-deficient individuals. Supplementation with L-methylfolate may be more effective than folic acid supplementation at increasing blood folate levels.

Folic acid is never included in any of our Seeking Health dietary supplements. This artificial version of folate is not well-utilized by the body and can produce adverse effects. Folic acid must go through several enzymatic steps before it is converted into usable methylfolate. Its inefficient chemical structure may even slow down your SLC191A, DHFR, and MTHFR genes to the point of folate deficiency! Folic acid can also block usable folate from entering your cells, further contributing to folate deficiency.

By supplementing with the natural form of folate as L-5-MTHF, you bypass the MTHFR enzyme. The methylated form, L-5-methylfolate (L-5-MTHF), requires no additional metabolic steps to be used by the body. This is why it is often the preferred choice for those with folate absorption or metabolic defects.

L-methylfolate also supports the production of important mood neurotransmitters. These include dopamine, serotonin, melatonin, epinephrine, and norepinephrine. This is how supplementation with L-5-MTHF can help to support a healthy mood.

Seeking Heath’s L-methylfolate provides a pure, non-racemic form of L-methylfolate. Each easy-to-take capsule offers a potent dose of 1,700 mcg DFE of folate as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt. This superior form supports healthy methylation, mood, and more.

Because folate needs B12 to support proper methylation, be sure to pair L-methylfolate with a bioactive form of B12, such as Active B12 1000.

Now you can go about your day with confidence, knowing your methylation cycle is firing on all cylinders with L-methylfolate!

L-Methylfolate
Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60

AMT %DV
Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt) 1,700 mcg DFE (1000 mcg) 425%
% DV (Daily Value) based on standard 2,000 calorie daily intake
**Daily Value not established

Other Ingredients: Microcrystalline cellulose, vegetarian capsule (hypromellose and water), ascorbyl palmitate, L-leucine, and silica.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Capsules
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, and Artificial Flavors

How to Use L-Methylfolate

Suggested Use

As needed, take 1 capsule with or without food. Do not take within 5 hours of bedtime as it may interfere with sleep. Use as directed by your healthcare professional.

Warnings

Consult with your healthcare professional prior to use. Do not use if inner tamper seal is damaged.

FAQs for L-Methylfolate

What is the purpose of each ingredient in L-Methylfolate?

Ingredients Purpose
Folate (Quatrefolic® 6S)-5-methyltetrahydrofolate, glucosamine salt) Supports a healthy nervous system, methylation, homocysteine recycling, and prenatal regimen along with a healthy diet and lifestyle

How do I know if taking L-Methylfolate works? How do I improve its utilization?

L-methylfolate (L-5-MTHF) is a superior form of folate that is well-utilized in the body. This is because 80 percent of the human body's folate is in this form.

L-5-MTHF is the form of folate that is used for methylation. Methylation is simply when one compound donates a methyl group to another compound. By having a methyl group attached, the compound's function changes.

You know when L-methylfolate works because of how you feel. It's typically very fast to notice if it's working or not.

According to Dr. Ben Lynch, supplementing with L-methylfolate can support healthy:

  • Mental clarity
  • Attention and focus
  • Energy production
  • Vision
  • Memory and recall
  • Circulation, especially in the hands and feet
  • Normal blood pressure
  • Normal homocysteine levels

In order for L-methylfolate to work, it requires vitamin B12. Reduced oxidative stress is also needed for L-methylfolate to function.

L-methylfolate needs the following to support methylation:

  • Vitamin B12
  • Zinc
  • Glutathione
  • Reduced oxidative stress
  • Functional MTR enzymes

Talk to your qualified healthcare practitioner before starting methylfolate supplementation. A trained health professional will be able to determine the appropriate dosing and whether methylfolate is right for you.

Which folate is right for me?

Click here to view our Folate Supplement Comparison Chart.

Read this blog: The different forms of folate: which one is right for you?

This blog article explains folic acid side effects.

If you have a question that's not addressed
here, see all frequently asked questions.

VIEW ALL FAQS

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What our customers say

Real reviews from real customers.

4.8
Rated 4.8 out of 5 stars
Based on 85 reviews
Total 5 star reviews: 75 Total 4 star reviews: 7 Total 3 star reviews: 1 Total 2 star reviews: 0 Total 1 star reviews: 2
96%would recommend these products
85 reviews
  • TR Profile picture for Tatiana R.facebook logo
    Tatiana R.
    Verified Reviewer
    L-Methylfolate
    Reviewing
    L-Methylfolate
    Rated 3 out of 5 stars
    1 week ago
    Please bring back the lozenges

    I completely agree with the previous reviewer about discontinued lozenges, those worked great, and we were able to cut and adjust the dose. My kids are not able to swallow capsules yet, so lozenges were perfect. Now I have to find a way to give it to them which is not going to be easy. Please bring the lozenges back, we also used adenosyl - hydroxo lozenges B12 that kids loved!

  • SG
    Supplementing G.
    Verified Buyer
    L-Methylfolate
    Reviewing
    L-Methylfolate
    I do not recommend this product
    Rated 1 out of 5 stars
    1 month ago
    Disappointed Lozenges Discontinued

    Loved, loved, loved L5 MTHF lozenges, which were discontinued at end of 2023. I bought last 4 bottles to get me through next summer, when will have to attempt transition to capsules, which may NOT be Seeking Health capsules as would mean wasting 25% of every 1 mg capsule. I cut lozenges, as only take 750 mcg first thing in AM. In addition, capsules will NOT work well for me due to low stomach acid, thus requiring a complete overhaul of my complex morning routine. This is one product Seeking Health should consider reinstating. Thanks!

  • KS
    Krista S.
    Verified Buyer
    L-Methylfolate
    Reviewing
    L-Methylfolate
    I recommend this product
    Rated 5 out of 5 stars
    4 months ago
    Awesome!

    This combined with Adeno b12 has helped with my methylation tremendously!

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