Methylation is an extremely important biochemical reaction that’s happening every second in every cell of your body. On the cellular level, methylation is the process of transferring a methyl group (CH3) to a molecule, which activates the molecule so it can be used by the body.
For example, attaching a methyl group to folate transforms it into the active form known as 5-MTHF (l-methylfolate), which is the predominant form of folate found in the body and the only form that can cross the blood-brain-barrier. Likewise, adding a methyl group to homocysteine (a marker of inflammation and cardiovascular disease) converts it back into methionine, a harmless amino acid. The addition and removal of methyl groups to and from DNA are responsible for turning genes on and off.
People with the MTHFR gene mutation (especially the C677T variety) can have significant reductions in methylation (even if they take plenty of folate) and may benefit from supplementing with activated forms of folate, B12 and other methyl-supportive nutrients.* When you have two copies of the MTHFR gene (homozygous) it becomes even more important to provide methylation support for your body, however, taking high doses can lead to overmethylation. Common symptoms of too much methylation support include headaches, irritability, insomnia, runny nose, body pain, and itchy skin.
Optimal Methylate Chewable was created by Dr. Ben Lynch to address the need for an easy-to-take vitamin that supports methylation quickly, comprehensively, and gently. The lower amounts per serving allow you to optimize rather than overwhelm your methylation cycle. By supporting methylation gently, common unpleasant side effects of taking methylation support may be lessened or prevented completely.*
The targeted ingredients found in Optimal Methylate Chewable are designed to provide the following benefits and actions:*
Riboflavin is the primary vitamin needed to support the MTHFR enzyme. Riboflavin also helps in the recycling of glutathione (the body’s master antioxidant) along with supporting the metabolism of serotonin, epinephrine, norepinephrine, and histamine
Niacin helps to support histamine metabolism while providing a calming effect
Vitamin B6 is used in the conversion of harmful homocysteine into beneficial glutathione. Vitamin B6 also supports the production of GABA, a calming neurotransmitter
Folate is included in two forms: 80% as L-5-MTHF (l-methylfolate) and 20% as folinic acid. L-5-MTHF is the active methylated form of folate needed to produce the body's main methyl donor, SAMe. Folinic acid is involved in the production of energy and BH4 (an important cofactor in the body)
Vitamin B12 is included in three different forms: methylcobalamin to support methylation, hydroxocobalamin to balance reactive forms of nitric oxide and hydrogen sulfide, and adenosylcobalamin to support mitochondrial health and energy production
Choline and betaine (TMG) support the recycling of homocysteine back to methionine via the BHMT enzyme. Choline also supports the synthesis of phosphatidylcholine, which uses a large majority of the body’s methylation reactions to produce
Magnesium is required for the production of the body's main methyl donor, SAMe. Magnesium also supports the COMT enzyme, which can be a common culprit of methylation side effects
Zinc is an important cofactor for the MTR and BHMT enzymes, which helps them bind to homocysteine. Zinc also supports the reduction of excitatory NMDA activity
Molybdenum helps support the metabolism of sulfites, which is important if one consumes too much methylation support
PQQ helps support the reduction of oxidative stress, which when present, can slow the methylation cycle. PQQ is also protective to BH4, which helps support the production of neurotransmitters and the healthy form of nitric oxide
Serving Size: 1
Servings Per Container: 60
Suitable for Vegans and Vegetarians
Dairy, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat
Chew 1 tablet with or without food. Tablets may be cut into halves or quarters if a lesser dose is desired and taken throughout the day. Do not take within 5 hours of bedtime as it may interfere with sleep. Use as directed by your healthcare professional.
Children and pregnant or lactating women should consult their healthcare professional prior to use. Do not use if tamper seal is damaged.
Looking for complementary support?
Additional supplements that complement Optimal Methylate Chewable are: