Optimal Methylate Chewable - 60 Tablets

Rated 4.0 out of 5
22 Reviews
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Key Benefits and Actions*

Optimal Methylate Chewable by Seeking Health provides a lower dose of methylation support for those who are sensitive to the higher doses found in most methyl support supplements. We’ve included active forms of folate, vitamin B12 and nine other targeted nutrients to help support and optimize healthy methylation processes throughout your body.*

Methylation is an extremely important biochemical reaction that’s happening every second in every cell of your body. On the cellular level, methylation is the process of transferring a methyl group (CH3) to a molecule, which activates the molecule so it can be used by the body.


For example, attaching a methyl group to folate transforms it into the active form known as 5-MTHF (l-methylfolate), which is the predominant form of folate found in the body and the only form that can cross the blood-brain-barrier. Likewise, adding a methyl group to homocysteine (a marker of inflammation and cardiovascular disease) converts it back into methionine, a harmless amino acid. The addition and removal of methyl groups to and from DNA are responsible for turning genes on and off.


People with the MTHFR gene mutation (especially the C677T variety) can have significant reductions in methylation (even if they take plenty of folate) and may benefit from supplementing with activated forms of folate, B12 and other methyl-supportive nutrients.* When you have two copies of the MTHFR gene (homozygous) it becomes even more important to provide methylation support for your body, however, taking high doses can lead to overmethylation. Common symptoms of too much methylation support include headaches, irritability, insomnia, runny nose, body pain, and itchy skin.


Optimal Methylate Chewable was created by Dr. Ben Lynch to address the need for an easy-to-take vitamin that supports methylation quickly, comprehensively, and gently. The lower amounts per serving allow you to optimize rather than overwhelm your methylation cycle. By supporting methylation gently, common unpleasant side effects of taking methylation support may be lessened or prevented completely.*


The targeted ingredients found in Optimal Methylate Chewable are designed to provide the following benefits and actions:*

  • Riboflavin is the primary vitamin needed to support the MTHFR enzyme. Riboflavin also helps in the recycling of glutathione (the body’s master antioxidant) along with supporting the metabolism of serotonin, epinephrine, norepinephrine, and histamine

  • Niacin helps to support histamine metabolism while providing a calming effect

  • Vitamin B6 is used in the conversion of harmful homocysteine into beneficial glutathione. Vitamin B6 also supports the production of GABA, a calming neurotransmitter

  • Folate is included in two forms: 80% as L-5-MTHF (l-methylfolate) and 20% as folinic acid. L-5-MTHF is the active methylated form of folate needed to produce the body's main methyl donor, SAMe. Folinic acid is involved in the production of energy and BH4 (an important cofactor in the body)

  • Vitamin B12 is included in three different forms: methylcobalamin to support methylation, hydroxocobalamin to balance reactive forms of nitric oxide and hydrogen sulfide, and adenosylcobalamin to support mitochondrial health and energy production

  • Choline and betaine (TMG) support the recycling of homocysteine back to methionine via the BHMT enzyme. Choline also supports the synthesis of phosphatidylcholine, which uses a large majority of the body’s methylation reactions to produce

  • Magnesium is required for the production of the body's main methyl donor, SAMe. Magnesium also supports the COMT enzyme, which can be a common culprit of methylation side effects

  • Zinc is an important cofactor for the MTR and BHMT enzymes, which helps them bind to homocysteine. Zinc also supports the reduction of excitatory NMDA activity

  • Molybdenum helps support the metabolism of sulfites, which is important if one consumes too much methylation support

  • PQQ helps support the reduction of oxidative stress, which when present, can slow the methylation cycle. PQQ is also protective to BH4, which helps support the production of neurotransmitters and the healthy form of nitric oxide

Suitable for Vegans and Vegetarians

Free of:

Milk, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat, Artificial Colors, Artificial Flavors

Suggested Use

Chew 1 tablet with or without food. Tablets may be cut into halves or quarters if a lesser dose is desired and taken throughout the day. Do not take within 5 hours of bedtime as it may interfere with sleep. Use as directed by your healthcare professional.

Warnings

Children and pregnant or lactating women should consult their healthcare professional prior to use. Do not use if tamper seal is damaged.

Looking for complementary support?

Additional supplements that complement Optimal Methylate Chewable are:

Serving Size: 1 Tablet
Servings Per Container: 60

AMT %DV
Calories 5
Total Carbohydrate 1 g <1%
Riboflavin (50% as riboflavin and 50% as riboflavin 5'-phosphate sodium) 2.5 mg 192%
Niacin 2.5 mg 16%
Vitamin B6 (50% as pyridoxal 5'-phosphate and 50% as pyridoxine HCl) 2.5 mg 147%
Folate [80% as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt and 20% as calcium folinate] 170 mcg DFE (100 mcg) 43%
Vitamin B12 (50% as methylcobalamin, 39% as hydroxocobalamin, and 11% as adenosylcobalamin) 38 mcg 1,583%
Choline (as choline bitartrate) 25 mg 5%
Magnesium (as magnesium citrate) 25 mg 6%
Zinc (as Zinc Bisglycinate Chelate§) 1.25 mg 11%
Molybdenum (as Molybdenum Glycinate Chelate§) 12 mcg 27%
Betaine Anhydrous (trimethylglycine) 62.5 mg **
Pyrroloquinoline Quinone Disodium Salt 1.5 mg **
Percent Daily Values are based on a 2,000 calorie diet.
**Daily Value (DV) not established.

Other Ingredients: Xylitol, natural flavors, ascorbyl palmitate, silica, stevia leaf extract, sea salt, monk fruit extract, citric acid, and malic acid.

Learning Center Find product FAQ and more! Click here.
Cost Per Serving $0.63
Delivery Method Chewable Tablet
Storage Keep tightly closed in a cool, dry place out of reach by children.
Age Suitability Adult
Manufactured In USA
Case Quantity 24
Dimensions (in.) Length: 2.5 / Width: 2.5 / Height: 5.25
Weight (lb.) 0.4000
SKU METHYL-60-TAB
Barcode 810007520698
Return Policy Learn more about our Return Policy.
average rating 4.0 out of 5
Based on 22 reviews
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68% of reviewers would recommend this product to a friend
22 Reviews
Reviewed by Lois L.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Tastes good, easy to take

Nice way to take the vitamins I need.

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Reviewed by Ellen A.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Great pill for comprehensive methylation support

Cherry flavor is pretty good and dissolves easily. I noted increased energy levels and

feelings of well-being.

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Reviewed by María
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Awesome Product

Finally, a B complex supplement that doesn’t give me anxiety! I love the taste too. I will continue purchasing it.

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Reviewed by Marianne
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

A genius formulation for MTHFR

I was on the email list to buy this when it first came out. An adult family member with homozygous mthfr had struggled for YEARS, working with a functional medicine practitioner, to solve methylation issues. Dr Lynch has created a formulation that includes cofactors from all around the chemical pathway that can help the methylfolate be tolerated by sensitive individuals. Pure genius! We started with half, then one full lozenge, then worked up to 2 morning and 2 midday. The response has been miraculous. If you can put this same formulation in a capsule for an adult, we would love it, and would buy it. However, this IS such an excellent product; we can deal with the tangy chewable and will always keep buying it. It is a life changer, and thank you Dr Lynch for putting your heart, soul and mind into your supplements for real people needing real help!

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Reviewed by Laura
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

A+

I feel this is a great MTHFR supplement. Easy to take and great taste. I am taking it for pyroluria and homogygous c1289. Helping to keep my migraines at bay.

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