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Methylate - 60 Tablets

Rated 4.3 out of 5
Based on 69 reviews

Methylate - 60 Tablets

Original price $39.95 - Original price $203.76
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$39.95 - $203.76
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Key Benefits and Actions

Key Benefits and Actions

  • Gentle methylation support
  • Supports healthy homocysteine levels
  • Quick and delicious energy production support

Who Needs Methylate

Could you use more pep in your step?

If you keep finding yourself in an afternoon slump, you may need methylation support.

Methylation is a process that affects nearly every biochemical process in your body. From providing mental clarity to ensuring your DNA replicates correctly, proper methylation is critical.

Specific nutrients are required for your methylation processes to run smoothly. These include active forms of B vitamins, methyl donors, and cofactors for your methylation pathway enzymes.

Methylate is a targeted methylation support formula designed by epigenetics expert Dr. Ben Lynch. It contains gentle doses of your daily essential methylation nutrients.

When people start taking methylation support, many discover that most formulas are far too potent. How do they know? They experience side effects such as headaches, irritability, or rapid heartbeat.

Methylate is a solution for people sensitive to the higher doses found in most methylation supplements. The lower dosage allows you to optimize, rather than overwhelm, your methylation cycle. By supporting methylation gently, common unpleasant side effects from methylated nutrients may be lessened or prevented completely.

Methylate includes active forms of folate, vitamin B12, and nine other targeted nutrients to support healthy methylation and homocysteine levels. You can take it alongside your multivitamin or B complex for additional methylation support.

People with common MTHFR genetic mutations often benefit from methylation support. Depending on the speed of their MTHFR enzymes, they may need lower or higher amounts of nutrition.

Do you want to support healthy homocysteine levels? The targeted nutrients in Methylate help your body convert homocysteine into harmless methionine. This supports healthy levels of homocysteine for cardiovascular wellness.

For a more potent formula, consider HomocysteX Plus, which provides higher doses of methylation nutrients for those who need more support.

If you’re looking for a tasty chewable vitamin that supports methylation quickly, comprehensively, and gently, then Methylate is for you!

Customer Review

Perfect B Complex

I really appreciate having this product. It has a broad spectrum of b vitamins but in very low doses. I used to have trouble getting the right amount but this has solved that problem. I only need this 2-3x because I eat well but I give one to my son every day as he doesn't eat that well 😉. Great product!

Key Ingredients In Methylate

  • Riboflavin: Supports MTHFR activity and folate pathway function.
  • Folate & B12: Provide methyl groups for methylation processes.
  • Zinc, Magnesium & Molybdenum: Cofactors for enzymes involved in homocysteine metabolism, sulfur metabolism, and SAMe production.
  • Choline: Supports phosphatidylcholine production and methylation via the CHDH enzyme.
  • PQQ: Provides additional antioxidant support.
  • Niacin: Cofactor for several enzymes in the methylation pathway.

Why Methylate Works

Methylation is a critical biochemical reaction happening constantly in every cell of your body. On the cellular level, methylation is the process of transferring a methyl group (CH3) to a molecule. This activates the receiving molecule so your body can use it.

The methylation cycle involves passing a methyl group from the amino acid methionine, turning it into homocysteine, then recycling homocysteine back into methionine. There are numerous enzymes involved in this process that require specific minerals and vitamins in order to function.

The targeted nutrients in Methylate support your methylation pathway enzymes to work optimally.

  • Riboflavin is a cofactor for the MTHFR gene, which helps to produce methylfolate.
  • Niacin is a cofactor for the MTRR enzyme, which allows B12 to participate in MTR enzyme methyl group transfer reactions.
  • Methylfolate & Vitamin B12 are both needed to recycle homocysteine back into methionine.
  • Zinc is a cofactor for the MTR and BHMT enzymes.
  • Vitamin B6 is needed as a coenzyme for the CBS enzyme to make glutathione from homocysteine.
  • Choline supports dirty CHDH or PEMT enzymes/genes.
  • Magnesium is a cofactor for the MAT1A enzyme.
  • Betaine (TMG) is a methyl donor and supports BHMT enzyme activity.
  • PQQ supports healthy oxidative stress levels. The B12 recycling enzymes, MTR and MTRR, function best in low oxidative stress environments.
  • Molybdenum supports sulfite metabolism. Some people are sensitive to sulfite production in the glutathione pathway when methylation is supported.

The nutrients in Methylate synergistically support a healthy methylation cycle and homocysteine recycling.

People with MTHFR gene mutations (especially the C677T variety) can have significant reductions in methylation. This is true even if they take plenty of folate! Many benefit from supplementing with the nutrient cofactors needed by methylation pathway enzymes.

When you have two copies of the MTHFR gene (homozygous), it becomes even more important to provide methylation support for your body. However, taking high doses can lead to over-methylation. Common symptoms of too much methylation support include headaches, irritability, insomnia, runny nose, body pain, and itchy skin.

Methylate provides lower doses of methylation nutrients. This is ideal if you are sensitive to the higher doses found in most methyl support supplements. With Seeking Health’s Methylate, you can support methylation gently, quickly, and comprehensively with only one delicious chewable vitamin per day!

Supplement Facts

Serving Size: 1 Tablet
Servings Per Container: 60

Riboflavin (as riboflavin and riboflavin 5'-phosphate sodium) 2.5 mg 192%
Niacin 2.5 mg NE 16%
Vitamin B6 (as pyridoxal 5'-phosphate and pyridoxine hydrochloride) 2.5 mg 147%
Folate [as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt and calcium folinate] 170 mcg DFE (100 mcg) 43%
Vitamin B12 (as MECOBALACTIVE® methylcobalamin, hydroxocobalamin, and adenosylcobalamin) 38 mcg 1,583%
Choline (as choline bitartrate) 25 mg 5%
Magnesium (as magnesium citrate) 25 mg 6%
Zinc (as Zinc Arginate Chelate§) 1.25 mg 11%
Molybdenum (as Molybdenum Glycinate Chelate§) 12 mcg 27%
Betaine Anhydrous (trimethylglycine) 62.5 mg *
Life PQQ (Pyrroloquinoline Quinone Disodium Salt) 1.5 mg *
*Daily Value (DV) not established.

Other Ingredients: Xylitol, natural flavors, ascorbyl palmitate, monk fruit extract, silica, salt, and malic acid.

  • Suitable For: Vegetarians and Vegans
  • Age Suitability: Adults
  • Delivery Method: Chewable Tablets
  • How To Store: Keep tightly closed in a cool, dry place out of reach by children.

Free Of: Eggs, Fish, Gluten, GMO, Milk, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use Methylate

Suggested Use

Chew 1 tablet with or without food. Tablets may be cut into halves or quarters if a lesser dose is desired and taken throughout the day. Do not take within 5 hours of bedtime as it may interfere with sleep. Use as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare professional prior to use. Do not use if tamper seal is damaged.

How to Enhance Methylate


Consider Pulsing

Dr. Ben Lynch recommends using certain dietary supplements based on your need for them. Start with a partial serving and increase slowly over time to the full serving, only if needed. When you start feeling good, consider reducing the serving size, skipping days, or pausing supplementation. Then take again when you feel you need it (stressful day, traveling, chemical exposure, etc.), hence "pulsing." Work with your qualified healthcare practitioner to determine what's best for you.


Pairs Well With

Multivitamin One, to provide your daily intake of key nutrients. Optimal Glutathione Plus, to support healthy aging, stress responses, and antioxidant defenses. Optimal Magnesium, provides magnesium in an optimal form to power over 300 enzymatic reactions in the body, including methylation and glutathione recycling.


Clean Your Genes

After years of suffering from unexplainable health issues, Dr. Ben Lynch, ND discovered the root cause - "dirty" genes. In his best-selling book, Dirty Genes, Dr. Ben Lynch describes the steps you can take to promote optimal epigenetic health. Ready to get started? Click here to take the Dirty Genes Quiz to find which of your genes are dirty!

Why Choose Seeking Health

Here at Seeking Health, we are committed to providing you the best in bioavailable supplements, methylation support, prenatal vitamins, genetic analysis tools, and more.

We strive to go above and beyond the average supplement company, which is why we allocate significant resources to testing all of our supplements for purity, potency, and label claims.

  • Third-party tested for heavy
    metals, microbials, and potency
  • Scientifically formulated by Dr. Ben Lynch, ND
  • Manufactured in the USA from globally
    sourced ingredients
  • Nutrients in their bioavailable
    forms for optimal absorption
  • cGMP facility registered by NSF International
Purity & Potency Tested & Assured
Scientifically Formulated by Dr. Ben Lynch
Manufactured in the USA from globally sourced ingredients third-party independently tested
Bioavailable Nutrients

FAQs for Methylate

What is the purpose of each ingredient in Methylate?

Ingredients Purpose
Riboflavin (50% as R-5-P and 50% as riboflavin) Cofactor for the MTHFR and MTRR enzymes
Niacin Cofactor for multiple enzymes in the methylation pathway including MTHFR, DHFR, and MTHFD1
Vitamin B6 (As P-5-P and pyridoxine HCl) Cofactor for the CBS enzyme
Folate (80% as Quatrefolic L-5-MTHF, glucosamine salt, and 20% as calcium folinate) Provides pre-methylated folate to be used in the transfer of methyl groups for methylation processes
Vitamin B12 (As MecobalActive methylcobalamin, adenosylcobalamin, hydroxocobalamin acetate) Provides support for methylation processes; B12 is needed alongside methylfolate for methylation to occur
Zinc (as TRAACS zinc bisglycinate chelate) Cofactor for the MTR enzyme
Molybdenum (as TRAACS molybdenum glycinate) Supports normal metabolism of sulfites
Betaine Anhydrous (TMG) Methyl donor for methylation processes
Choline (as choline bitartrate) Provides choline to support methylation (~70% of methylation goes towards making phosphatidylcholine and creatine)
Magnesium (as Magnesium citrate) Cofactor for the MAT enzyme; Needed for SAMe production
PQQ (Pyrroloquinoline Quinone Disodium Salt) Promotes healthy levels of oxidative stress to optimize the methylation cycle

Who is Methylate intended for?

Methylate is intended for those who do not tolerate higher dose methylation supplements. Methylate contains lower doses of B vitamins to gently support methylation and homocysteine recycling. It also includes folate and methionine pathway cofactors to comprehensively support methylation.

Methylate can also provide low-dose energy support throughout the day. Keep a bottle in your purse, car, or desk to support healthy, all-day energy levels, neurotransmitter production, and mood.

Those who dislike swallowing capsules may prefer this tasty chewable tablet!

How to use Methylate?

Chew one tablet with or without food, or as suggested by your healthcare professional. Take with food if you experience nausea or an upset stomach when taking this product on an empty stomach.

It is suggested to drink a small amount of filtered water after consumption, however, this is not necessary. You can cut the tablets into halves or quarters for a lower dosage, if desired.

Do not take within 5 hours of bedtime as it may interfere with sleep. The B vitamins and choline may have an energizing effect on some sensitive individuals, so it is best taken in the morning or early afternoon.

If you have a question that's not addressed
here, see all frequently asked questions.


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What our customers say

Real reviews from real customers.

average rating 4.3 out of 5
Based on 69 reviews
  • 5 Stars
    49 Reviews
  • 4 Stars
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  • 3 Stars
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  • 2 Stars
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83% of reviewers would recommend this product to a friend
69 Reviews
Reviewed by Alexandru Cristian P., from Romania
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I recommend this product
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I understand
Rated 5 out of 5
Review posted

Amazing product

i m happy i discovered this product mostly because it has a broad spectrum of B vitamins but in very low doses even if the pill is a little bit too large

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Reviewed by Jacqueline L., from United States
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Methylate - 60 Tablets BOGO
Methylate - 60 Tablets BOGO
I recommend this product
We are not able to publish reviews that reflect atypical results or suggest that any product can diagnose, treat, cure, or prevent any disease, disorder, or chronic health condition. Please be mindful of these restrictions as you leave your review and thank you for all your feedback!
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Rated 4 out of 5
Review posted

Better energy

I have extreme fatigue most days. And if I don't take this, I know it. I can get through most of the day without crashing. Now if I could only stop the cravings!!

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Reviewed by Lori, from United States
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I recommend this product
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Rated 5 out of 5
Review posted

Sooooo good!

I love these tablets especially when I am hiking or doing any sort of high-energy activity. I simply take a piece of the wafer and within minutes feel energized! I always have them with me!

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