Skip to content
Where's the plastic seal? Learn about our decision to cut plastic waste from our products. CLICK HERE
Where's the plastic seal? Learn about our decision to cut plastic waste from our products. CLICK HERE

Optimal Sleep II - WSL + BOGO

  • Melatonin-free, natural sleep aid
  • Supports healthy sleep onset for occasional sleepless nights
  • Supports balanced brain chemistry and relaxation
For a limited time, Buy 1 Get 1, Buy 3 Get 3 or Buy 6 Get 6. Select and add to cart.

THIS PRODUCT WAS MANUFACTURED ON 6/2021. - It is typical for dietary supplement products to retain potency and freshness for approximately 2 to 3 years from the manufacture date under proper storage conditions.

Who Needs Optimal Sleep II

Do you find yourself staring at the ceiling some nights, counting sheep? Do you ever feel tired but wired?

On those sleepless nights, you may benefit from specific nutrients that help metabolize excitatory brain chemicals.

Optimal Sleep II is a melatonin-free sleep aid. The synergistic nutrients support healthy sleep onset.

This melatonin-free formula is designed by epigenetics expert, Dr. Ben Lynch. It supports falling asleep by providing the nutrient cofactors needed for healthy neurotransmitter metabolism. Enzymes use these nutrient cofactors in biochemical pathways that allow you to relax, produce melatonin, and clear excitatory catecholamines from your brain. This formula does not contain melatonin or 5-HTP.

Healthy sleep requires balanced brain chemistry. This is dependent on proper catecholamine metabolism. Catecholamines are hormones that also function as neurotransmitters. They include dopamine, norepinephrine, and epinephrine. Catecholamines are responsible for feelings of excitement, nervousness, and anger, which can all interfere with sleep. Sleep problems can result from a build-up of these excitatory neurotransmitters in your brain.

Optimal Sleep II supplies the specific nutrients needed to break down and clear catecholamines from your system.

The nutrients found in Optimal Sleep II:

  • Act as cofactors for enzymes that metabolize excitatory brain chemicals (dopamine, epinephrine, etc.)
  • Serve as enzyme cofactors to break down potentially toxic byproducts from neurotransmitter metabolism (ammonia, aldehydes, etc.)
  • Support healthy serotonin levels
  • Are ideal for those with slow MAOA and COMT genes/enzymes

The main enzymes that break down dopamine and serotonin are MAOA and COMT. Unlike our original Optimal Sleep formula (intended for people with faster MAOA and COMT enzymes), this product is designed for those who feel that their MAOA and COMT enzymes are working slower. Due to genetics or epigenetics, slower MAOA and COMT enzymes cause excitatory brain chemicals to build up. You can read Dr. Ben Lynch’s bestselling book Dirty Genes or use the StrateGene® Report to learn your MAOA and COMT status.

Optimal Sleep II by Seeking Health is intended to help you fall asleep on those occasional sleepless nights. If you need support staying asleep, consider our original Optimal Sleep.

The key nutrients in Optimal Sleep II target the enzymes and biochemical processes responsible for producing healthy sleep. If you find yourself struggling to calm down after crawling into bed, Optimal Sleep II might just be the perfect partner for your nighttime routine.

Customer Review

Best Sleep Hack Yet!

After years of living on the graveyard shift & then returning to a day shift I have struggled to reset my circadian rhythm. Supplementing with melatonin has never worked for me. Optimal Sleep ll has been a game changer for me. After a few weeks using this I have much better deep sleep and wake up less often. My Fitbit scores show a clear change in my sleep patterns. I highly recommend this product! ~Katie M.

Key Ingredients In Optimal Sleep II

  • Riboflavin:Cofactor for the MAOA enzyme, which helps to metabolize dopamine for feelings of calm. Supports healthy serotonin levels.
  • Magnesium:Cofactor for the COMT enzyme to support the breakdown of excitatory dopamine, epinephrine, and norepinephrine.
  • Lithium & Vitamin B6:Support glutamate metabolism and feelings of calm.
  • Ornithine:This amino acid supports normal ammonia breakdown from neurotransmitter metabolism, as ammonia can lead to excitation in the brain.
  • Thiamine, Zinc & Niacin:Cofactors for the ALDH2 and ADH1B enzymes. Support the normal breakdown of potentially harmful and excitatory DOPAL, DOPEGAL, and other aldehydes.

Why Optimal Sleep II Works

Optimal Sleep II supports the breakdown of excitatory brain neurotransmitters. A buildup of catecholamines (dopamine, epinephrine, norepinephrine) can interfere with your ability to fall asleep.

Two genes that play important roles in sleep are Monoamine Oxidase A (MAOA) and Catechol-O-Methyltransferase (COMT). These genes code for the production of enzymes of the same name. MAOA and COMT enzymes are found in your dopamine and serotonin biochemical pathways. This is where catecholamines are created and broken down.

  • MAOA: Enzyme that breaks down dopamine and serotonin.
  • COMT: Enzyme that supports the normal metabolism of estrogen and catecholamines including dopamine.

If your MAOA or COMT genes/enzymes are working too slow, it can lead to a buildup of dopamine and serotonin. Elevated brain levels of these excitatory neurotransmitters can make it difficult to calm down at night.

Genetic mutations or environmental stressors can slow MAOA and COMT enzyme activity. Slow MAOA and COMT enzymes can reduce your ability to break down stimulating catecholamines along with their potentially harmful metabolic byproducts.

Optimal Sleep II provides the nutrient cofactors needed by your MAOA and COMT enzymes to function. Riboflavin (vitamin B2) is a cofactor for the MAOA enzyme. It helps metabolize dopamine for feelings of calm. The COMT enzyme requires magnesium to support the normal breakdown of dopamine, epinephrine, and norepinephrine.

The normal metabolism of catecholamines and serotonin produces potentially toxic and stimulating byproducts, such as ammonia, DOPAL, DOPEGAL, and 5-HIAL. These can lead to uncomfortable side effects, trouble sleeping, and cellular damage.

Optimal Sleep II contains thiamin, zinc, and niacin. These are cofactors for the ALDH and ADH1B enzymes, which help break down the potentially harmful byproducts of catecholamine metabolism. The amino acid ornithine is included to support normal ammonia breakdown and clearance.

Glutamate is another stimulating brain neurotransmitter. High levels can interfere with your ability to fall asleep. Optimal Sleep II includes nutrients needed to break down glutamate. Lithium, magnesium, and vitamin B6 also support production of the calming neurotransmitter, GABA.

A gentle serving of ashwagandha and phosphatidyl serine is included to support cortisol regulation. Healthy cortisol levels are essential for sleep initiation.

The targeted nutrients in Optimal Sleep II support healthy sleep onset for those occasional sleepless nights. It is ideal for those with slow MAOA and COMT gene and enzyme activity, which can be determined with the StrateGene® Report. Rest assured with Optimal Sleep II by Seeking Health.

Optimal Sleep II
Supplement Facts

Serving Size: 2 Capsules
Servings Per Container: 30

Thiamin (as thiamine hydrochloride) 5 mg 417%
Riboflavin (as riboflavin 5'-phosphate sodium) 5 mg 385%
Niacin 15 mg 94%
Vitamin B6 (as pyridoxal 5'-phosphate) 5 mg 294%
Magnesium (as DiMagnesium Malate§ and magnesium acetyl taurine) 125 mg 30%
Zinc (as Zinc Bisglycinate Chelate§) 7 mg 64%
L-Ornithine hydrochloride 160 mg **
KSM-66 Ashwagandha Extract (Withania somnifera)(root)(5% total withanolides) 125 mg **
Phosphatidylserine 25 mg **
Lithium (as lithium orotate) 2.5 mg **
**Daily Value (DV) not established.

Other Ingredients: Vegetarian capsule (hypromellose and water) and ascorbyl palmitate.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Capsules
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use Optimal Sleep II

Suggested Use

Take 2 capsules away from food 30 minutes prior to bedtime, or use as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare professional prior to use. Do not use if tamper seal is damaged.

FAQs for Optimal Sleep II

What is the purpose of each ingredient in Optimal Sleep II?

Ingredients Purpose
Thiamine Cofactor for the ALDH2 enzyme to support the breakdown of potentially harmful DOPAL, DOPEGAL, 5-HIAL, and other aldehydes
Riboflavin Cofactor for the MAOA enzyme which breaks down dopamine for feelings of calm; Supports healthy serotonin levels
Niacin Cofactor for the ALDH2 enzyme to support the breakdown of potentially harmful DOPAL, DOPEGAL, 5-HIAL, and other aldehydes; Supports healthy serotonin production
Vitamin B6 A cofactor for the AADC enzyme that helps to produce serotonin; Cofactor for the GAD enzyme to support glutamate metabolism for feelings of calm; Supports GABA production, a calming neurotransmitter
Magnesium Cofactor for the COMT enzyme to support the normal breakdown of dopamine, epinephrine, and norepinephrine; Supports healthy regulation of excitatory glutamate by preventing calcium influx into cells; Supports healthy muscle relaxation
Zinc Supports hundreds of cellular processes and contributes to the building blocks of melatonin; Cofactor for enzymes that support the normal breakdown of potentially harmful aldehydes, including DOPEGAL
L-Ornithine hydrochloride Amino acid that helps to support normal ammonia breakdown, as ammonia can lead to excitation in the brain
Ashwagandha extract An adaptogenic herb that supports a healthy nervous system, cortisol response, mood, adrenal function, relaxation, and feelings of calm
Phosphatidylserine Sunflower-derived phospholipid; Supports healthy cortisol regulation, nervous system function, and a healthy mood for feelings of calm and relaxation
Lithium Supports healthy GABA production and glutamate metabolism for feelings of calm

Who is Optimal Sleep II intended for?

Optimal Sleep II is intended for adults seeking high-quality support for falling asleep on occasional sleepless nights. It is designed by epigenetics expert Dr. Ben Lynch for those with slow MAOA or slow COMT gene/enzyme activity. This can be determined with the StrateGene® Report or by reading Dr. Lynch’s bestselling book, Dirty Genes.

This sleep supplement supports normal catecholamine and glutamate metabolism, along with healthy GABA production to help you wind down and fall asleep at night.

Optimal Sleep II does not contain melatonin or 5-HTP, as some people are sensitive to melatonin supplements, herbal supplements, and other over-the-counter natural remedies. Many natural sleep aids contain melatonin or 5-HTP, which may not be tolerated or safe for long-term use. This formula is free from melatonin, 5-HTP, L-theanine, tryptophan, and valerian root.

Optimal Sleep II is designed to leave you feeling refreshed the next morning. Prescription sleep aids and over-the-counter sleep supplements like melatonin can have potential side effects, including drowsiness or a feeling of jet lag the day after taking them. Always talk to your doctor before using this product, especially if you have health conditions or diseases that need to be addressed, are pregnant, or breastfeeding. Consult with a sleep medicine doctor for medical advice if you have any sleep disorders, or struggle consistently to get a good night’s sleep.

Which sleep supplement is right for me?

Check out this Sleep Supplement Comparison Chart.

This blog will help you determine which sleep formula is best for you:

If you have a question that's not addressed
here, see all frequently asked questions.


Do you have Questions
for this Product?


What our customers say

Real reviews from real customers.

Rated 4.3 out of 5 stars
Based on 66 reviews
Total 5 star reviews: 39 Total 4 star reviews: 13 Total 3 star reviews: 8 Total 2 star reviews: 4 Total 1 star reviews: 2
85%would recommend this product
66 reviews
  • NS
    Nita S.
    Verified Buyer
    I recommend this product
    Rated 4 out of 5 stars
    3 weeks ago
    helps a little

    Sems to help somewhat but i still need to add magnesium and l theanine to help with sleep.

  • A Profile picture for Ana
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    4 weeks ago
    Great product

    For me it is a great product. I took 2 capsules 2 hour before sleep and it worked amazing

  • T
    Verified Reviewer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago

    I find this product very supportive. I have long needed support for a healthy night's sleep. It feels wonderful to fall asleep soon after getting into bed and to get a solid night's sleep. However, I believe if I take it too many nights in a row, I start to feel very dizzy. But it is hard not to take it because without it, my sleep does not seem as restful.

Reviews LoadedReviews Added