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R Lipoic Acid

SALE $29.95
  • Active R form of ALA (alpha lipoic acid)
  • Provides powerful antioxidant and energy support
  • Supports healthy nerves and glucose metabolism
DISCONTINUED - This product has been discontinued. For the same comprehensive support with healthy metabolism and energy production, try Acetyl-L-Carnitine .

Who Needs R Lipoic Acid

As you age, supporting optimal antioxidant activity and normal liver detoxification becomes increasingly important.

R Lipoic Acid (RLA) provides 100 mg of pure R-isomer alpha-lipoic acid (ALA) per vegan-friendly capsule.

R Lipoic Acid by Seeking Health provides the R-isomer form of lipoic acid. Normal alpha-lipoic acid supplements are an even mixture of the S- and R-isomers. However, in nature the R-form is the primary form found and it has a much higher bioavailability to cells.

Lipoic acid is often referred to as alpha lipoic acid or α-lipoic acid (ALA). R-Lipoic acid is a product that isolates the active component of ALA called R-Lipoic Acid. This powerful vitamin-like substance with antioxidant properties plays important roles in metabolism, energy production, and normal oxidative stress defenses.

R-Lipoic Acid has powerful antioxidant effects in the body. It has the unique ability to serve as an antioxidant in both water- and fat-soluble environments. This means it can go anywhere in your body and protect all types of tissues. R-Lipoic acid also assists in recycling important antioxidants such as vitamin C, vitamin E, coenzyme Q10, and glutathione.

Researchers have long known that R-Lipoic Acid plays a powerful role in energy production and normal glucose regulation. It acts as a coenzyme for the pyruvate dehydrogenase enzyme. This helps to clear glucose from the body and turn it into engergy by accelerating the conversion of pyruvate into acetyl CoA for the Krebs cycle.

A healthy body synthesizes lipoic acid naturally. With prolonged or increased physical stress, the body can struggle to produce enough to meet its functional needs. During these times, focusing on ALA supplementation with R-Lipoic Acid can be critical.

To maintain their function, the nerves in your eyes, brain, and extremities (hands and feet) benefit from antioxidant and energy support. Nerve damage, numbness, tingling, poor vision, and cognitive dysfunction can all result from low antioxidant and ATP levels. ALA helps to support healthy nerve function, eyes, and brain health thanks to its powerful energy producing and antioxidant properties.

ALA in the form of RLA supports normal liver detoxification capabilities. By helping to remove waste and toxins from cells. RLA also supports healthy fertility and aging.

R Lipoic Acid supports healthy:

  • Antioxidant activity
  • Aging processes
  • Stress responses
  • Energy production
  • Liver detoxification
  • Metabolism
  • Fertility
  • Cognitive, brain & nerve health
  • Blood sugar (glucose) regulation

Start experiencing the powerful effects of alpha-lipoic acid today with R Lipoic Acid by Seeking Health.

Customer Review

Consistent quality!

R Lipoic seems better tolerated to me than the other ALA, and it has helped me. The quality and potency seems consistent and reliable. Thank you Seeking Health! ~Leah D.

Key Ingredients In R Lipoic Acid

  • R-Lipoic Acid (as sodium R-lipoate): This R-isomer of alpha-lipoic acid (ALA) is known to be a more well-absorbed and bioactive form compared to the common S-isomer form. It acts as a powerful antioxidant in the body and also helps to recycle other antioxidants. Supports healthy nerve function, mental sharpness, liver function, carbohydrate breakdown, and eye health.

Why R Lipoic Acid Works

Your body produces lipoic acid naturally. It is also found in dietary supplements as alpha lipoic acid or R-lipoic acid (RLA). In nature, the R form is the only natural form. In supplement form, ALA is found as a racemic mixture of S and R isomers. Of the two forms, the R isomer is much more biologically active. The R isomer of ALA is able to more effectively bind substances that use it as cofactor. In fact, the R form may be inhibited by the S form, making it less effective at binding as a cofactor.

Energy production: R-lipoic acid plays a key role in supporting energy (ATP) production within cells. When glucose is turned into pyruvate, it must then be transformed into acetyl-CoA before it can be turned into ATP within a cell. R-lipoic acid assists the pyruvate dehydrogenase complex in carrying out this important step.

One of the things ALA in the R-form is well known for is the role it plays as a coenzyme for pyruvate dehydrogenase. This enzyme turns pyruvate into acetyl CoA which enters the Krebs cycle to eventually produce energy (ATP). RLA (along with B1, B2, B3, and B5) are all required as cofactors for the pyruvate dehydrogenase enzyme to function (and thus for energy production).

There is another similar enzyme called branched chain keto acid dehydrogenase that also uses R-lipoic acid as a cofactor. This enzyme assists in metabolizing the branched chain amino acids leucine, isoleucine, and valine into the Krebs cycle intermediates acetyl CoA and succinyl CoA that are readily used to make energy (ATP).

Antioxidant function: ALA in the R-form has a unique ability to function as an antioxidant in both water and fat soluble tissues. Its chemical structure allows it to be both lipophilic and hydrophilic, meaning it can travel in tissues filled with both water and fats. By donating electrons, it helps to regenerate NADPH which passes electrons to GSR (Glutathione-Disulfide Reductase). This enzyme recycles glutathione back into its active form, so it can be used again and again as the body’s master antioxidant. In a similar fashion, ALA in the R-form supports the recycling of other vital antioxidants in the body, including vitamins C, E, and others.

Liver detoxification: RLA is well known to support normal liver regeneration and protection against oxidative damage. It does this via a few different mechanisms. First, it acts as an antioxidant to directly quench free radicals by donating missing electrons. Second, RLA activates NRF2, a key transcription factor that activates detoxification and antioxidant genes. NRF2 stimulates anti-inflammatory enzymes and enzymes that promote phase 2 liver detox. Thus, R-Lipoic Acid can support normal damage repair by acting like an antioxidant, while also stimulating your genes to further produce antioxidant enzymes.

Mental sharpness: RLA provides neurological and brain support for mental sharpness. Its roles in ATP production, detoxification, and antioxidant function are protective to neurons. Nerves and the mitochondria in brain tissue are very susceptible to damage. There is a particularly low threshold for oxidative stress in brain mitochondria. R-Lipoic Acid supports healthy nerves, brain, and cognitive function via its versatile antioxidant activity. R-Lipoic Acid also supports the conversion of pyruvate to acetyl CoA to support healthy blood glucose levels. Elevated glucose levels have been repeatedly correlated to declines in cognitive function.

Each vegan-friendly capsule of R Lipoic Acid provides 100 mg of R-Lipoic Acid (as sodium R-lipoate). Unlike the common S-isomer, the R-isomer form is well-absorbed into the body due to its higher water solubility. Pick up a bottle today and start experiencing the beneficial effects of ALA in the all natural R-form.

R Lipoic Acid
Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60

R-Lipoic Acid (as sodium R-lipoate) 100 mg **
**Daily Value (DV) not established.

Other Ingredients: Microcrystalline cellulose, vegetarian capsule (hypromellose and water), ascorbyl palmitate, L-leucine, and silica.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Capsules
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use R Lipoic Acid

Suggested Use

Take 1 capsule away from food any time of day or as directed by your healthcare professional.


Children and pregnant, breastfeeding, or lactating women should consult their healthcare provider for medical advice prior to use. Do not use if tamper seal is damaged.

FAQs for R Lipoic Acid

What is the purpose of each ingredient in R Lipoic Acid?

Ingredients Purpose
R Lipoic Acid Supports healthy antioxidant activity, cellular energy production, metabolism, and cognition

Who is R Lipoic Acid intended for?

R Lipoic Acid is intended for individuals seeking a highly versatile nutrient to support healthy antioxidant defenses, normal nerve sensations in hands and feet, healthy cognitive function, and metabolism. The R- isomer of alpha-lipoic acid used in this formula is shown to be more bioavailable compared to the commonly used ALA supplements that have a mixture of both the S- and R-isomers.

Is R Lipoic Acid the stabilized form of Alpha Lipoic Acid?

Yes, R Lipoic Acid by Seeking Health contains stable R-isomer of Alpha Lipoic Acid, which carries an approximately three year shelf life. This is important as both isomers of ALA can be susceptible to oxidation or degradation if unstable or exposed to elements such as oxygen, heat, or light. Our product is designed to remain intact and effective under normal storage and use conditions for 2 years from the date of manufacture.

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What our customers say

Real reviews from real customers.

Rated 4.8 out of 5 stars
Based on 57 reviews
Total 5 star reviews: 51 Total 4 star reviews: 3 Total 3 star reviews: 2 Total 2 star reviews: 0 Total 1 star reviews: 1
95%would recommend these products
57 reviews
  • IM
    IRINA M.
    Verified Buyer
    R Lipoic Acid
    R Lipoic Acid
    I recommend this product
    Rated 5 out of 5 stars
    21 hours ago
    As always, makes a great difference~

    My liver is happy, my mood is great. I am able to get much more done :)

  • LS
    Linda S.
    Verified Buyer
    R Lipoic Acid
    R Lipoic Acid
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    Great product

    R-alpha Lipoic Acid is a great supplement and SEEKING HEALTH’s product lives up to expectations, as always.

    Thank you, Dr. Lynch! I’m very grateful to you and your products.

    Linda Seidman

  • NB Profile picture for New logo
    New B.
    Verified Reviewer
    R Lipoic Acid
    R Lipoic Acid
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Mitocondrial energy

    Antioxidant support and mitocondrial energy

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