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  • Provides 250 mg of S-Adenosyl-L-methionine (SAMe) per 2 vegan capsules
  • Supports methylation as the body’s main methyl donor
  • Supports healthy mood, liver function, joint comfort, and histamine metabolism

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High End Ingredients

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Excellent product, acid resistant capsules etc. I use the pulse method with this one. So far so good. ~Amy J.

Do you have histamine concerns, mood imbalances, or want to support healthy joints?

You may be deficient in your body’s main methyl donor—S-adenosylmethionine—also known as SAMe.

SAMe by Seeking Health provides 250 mg of S-adenosyl-L-methionine (SAMe) per acid-resistant, vegetarian capsule.

SAMe is a vulnerable nutrient. Many SAMe supplements on the market are unstable. We use acid-resistant capsules designed for optimal delivery of SAMe to the gut for absorption. To further optimize stability and prevent degradation, the capsules are protected from moisture and air in a desiccated bottle.

SAMe (S-adenosylmethionine or S-adenosyl-L-methionine) is your body's main methyl donor. It is found in nearly every tissue and fluid. It is involved in hundreds of biochemical reactions in the human body. By providing your body methyl groups, SAMe plays vital roles in DNA expression, neurotransmitter and hormone balance, normal liver cell regeneration, and much more.

SAMe aids in normal cartilage production, playing a major role in joint and bone health. SAMe is also an important part of histamine intolerance protocols. It is a cofactor for the HNMT enzyme which helps to break down histamine for healthy inflammatory responses and mast cell balance.

SAMe is a nutrient cofactor for many important enzymatic reactions in the body, including the COMT enzyme. COMT helps you break down excess dopamine to support a healthy mood and feelings of calm.

Because so many compounds and processes in your body depend upon methyl groups, SAMe is known to support many areas of health.

SAMe by Seeking Health supports healthy:

  • DNA expression
  • Neurotransmitter synthesis & metabolism
  • Hormone balance
  • Bone & Joint health
  • Liver function
  • Positive mood & Cognitive function
  • Cell membranes
  • Energy production
  • Methylation & Transsulfuration pathways
  • Glutathione production

Now you can support your mood, methylation, and more with SAMe by Seeking Health.

Key Ingredients

Inside the Uncompromising Quality of Our Ingredients

  • S-adenosyl-L-methionine (SAMe)
    Your body's main methyl donor. Supports a healthy mood, joint comfort, liver health, healthy histamine metabolism, and normal genetic expression.

Suggested Use

Take two capsules 45 minutes before or 60 minutes after a meal or as recommended by your healthcare provider. Taking away from food increases absorption.


Children and pregnant, lactating, or breastfeeding women should consult their healthcare professional prior to use. Do not use if tamper seal is damaged. If you are taking any medications for depression or anxiety, click here.

Suitable for


Delivery Method


How to Store

Keep closed in a cool, dry place out of reach by children.

  • No Artificial Preservatives
  • No Artificial Flavors
  • No Artificial Colors
  • Wheat-Free
  • Tree-Nut-Free
  • Shellfish-Free
  • Soy-Free
  • Peanut-Free
  • GMO-Free
  • Gluten-Free
  • Fish-Free
  • Egg-Free
  • Dairy-Free

What our customers say

Real reviews from real customers.

Rated 4.8 out of 5 stars
Based on 69 reviews
Total 5 star reviews: 63 Total 4 star reviews: 2 Total 3 star reviews: 2 Total 2 star reviews: 0 Total 1 star reviews: 2
94%would recommend this product
69 reviews
  • DS
    david s.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Just what I needed!

    I noticed a huge difference in my mood while taking this. Thanks for all the info shared!

  • LM
    Lisa M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago

    I love the bogo, I have to take them daily having MTHFR. Great deal fast shipping

  • VM
    Vanessa M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago

    After taking SAM-e, I feel like my body is lighter-more fluid! Hard to explain but I feel as if my system is "moving" not stagnant.

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