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  • Provides 250 mg of S-Adenosyl-L-methionine (SAMe) per 2 vegan capsules
  • Supports methylation as the body’s main methyl donor
  • Supports healthy mood, liver function, joint comfort, and histamine metabolism

Who Needs SAMe

Do you have histamine concerns, mood imbalances, or want to support healthy joints? You may be deficient in your body’s main methyl donor—S-adenosylmethionine—also known as SAMe.

SAMe by Seeking Health provides 250 mg of S-adenosyl-L-methionine (SAMe) per acid-resistant, vegetarian capsule.

SAMe is a vulnerable nutrient. Many SAMe supplements on the market are unstable. We use acid-resistant capsules designed for optimal delivery of SAMe to the gut for absorption. To further optimize stability and prevent degradation, the capsules are protected from moisture and air in a desiccated bottle.

SAMe (S-adenosylmethionine or S-adenosyl-L-methionine) is your body's main methyl donor. It is found in nearly every tissue and fluid. It is involved in hundreds of biochemical reactions in the human body. By providing your body methyl groups, SAMe plays vital roles in DNA expression, neurotransmitter and hormone balance, normal liver cell regeneration, and much more.

SAMe aids in normal cartilage production, playing a major role in joint and bone health. SAMe is also an important part of histamine intolerance protocols. It is a cofactor for the HNMT enzyme which helps to break down histamine for healthy inflammatory responses and mast cell balance.

SAMe is a nutrient cofactor for many important enzymatic reactions in the body, including the COMT enzyme. COMT helps you break down excess dopamine to support a healthy mood and feelings of calm.

Because so many compounds and processes in your body depend upon methyl groups, SAMe is known to support many areas of health.

SAMe by Seeking Health supports healthy:

  • DNA expression
  • Neurotransmitter synthesis & metabolism
  • Hormone balance
  • Bone & Joint health
  • Liver function
  • Positive mood & Cognitive function
  • Cell membranes
  • Energy production
  • Methylation & Transsulfuration pathways
  • Glutathione production

Now you can support your mood, methylation, and more with SAMe by Seeking Health.

Customer Review


Excellent product, acid resistant capsules etc. I use the pulse method with this one. So far so good. ~Amy J.

Key Ingredients In SAMe

  • S-adenosyl-L-methionine (SAMe): Your body's main methyl donor. Supports a healthy mood, joint comfort, liver health, healthy histamine metabolism, and normal genetic expression.

Why SAMe Works

Methylation is a critical chemical process in the human body. It is responsible for genetic expression, activating folate, metabolizing homocysteine, and many more vital biochemical functions. Methylation involves transferring a tiny molecule called a methyl group (CH3) to another molecule. The addition of a methyl group essentially ‘activates’ the receiving molecule by changing its shape. A common example of methylation is the addition of a methyl group to folate. This converts folate into its active form known as 5-MTHF (methylfolate).

The body’s main methyl donor is SAMe (S-adenosylmethionine). SAMe travels around the body, donating methyl groups to molecules in need. Once activated, these molecules can now perform their jobs of keeping our body systems running smoothly. Because so many compounds and processes in your body depend upon methyl groups and methylation, SAMe is known to support many areas of health, including sleep, mood, joints, and histamine sensitivity.

It is important to realize that 80% of all methylation in the human body is used to make two important compounds: creatine and phosphatidylcholine.

  • When one carbon is passed from SAMe to guanidinoacetate, creatine is made. Creatine is an essential component for maintaining optimal energy levels in muscle and brain tissues.

  • When three carbons are passed from SAMe to phosphatidylethanolamine and its metabolites, phosphatidylcholine is made. Phosphatidylcholine (PC) is the primary component found in cell membranes. It is also a vital constituent of bile. Without it, cells would fall apart, digestion would be challenged, and many environmental toxins could not be excreted via the bile.

While 80% of all methylation in the human body is used to make creatine and PC, there are hundreds of other processes that rely on SAMe donating its methyl groups, including DNA expression. The addition of methyl groups tells your DNA how and where to function.

Methyl groups also bind toxins and excess estrogen. This facilitates their excretion from the body. The addition of methyl groups to N-acetylserotonin produces melatonin. The number of ways that methylation controls your biochemistry is too long to list.

The primary source of methyl groups in your body is SAMe. SAMe is derived from the amino acid methionine. With the help of numerous enzymes and cofactor nutrients (including magnesium, folate, B12, and riboflavin), methionine can be recycled to make SAMe once again. This entire process of methionine becoming SAMe and being recycled back to methionine is often called methylation or the methylation cycle. However, certain conditions, or blocks in the methylation cycle, can reduce the amount of SAMe your body is able to synthesize.

Many people have genetic variations that slow down their methylation enzymes. Research indicates that over 50% of the population has an MTHFR genetic mutation.Your MTHFR gene and enzymes play a vital role in keeping your methylation cycle running smoothly. Others may be deficient in any one of the cofactor nutrients required to synthesize SAMe. In either case, SAMe production can become diminished.

By supplementing with SAMe, you can support your body’s own production of this critical methyl donor. SAMe by Seeking Health supports the health and function of:

  • Mood: SAMe is required for the synthesis of mood-related neurotransmitters and is a powerful nutritional method of supporting healthy mood and emotional well-being.
  • Joints: SAMe helps to incorporate sulfate groups into proteoglycans which help to maintain cartilage and support joints.
  • Liver: SAMe controls many vital hepatic functions. Liver function may be less than optimal when liver cells do not have adequate nutrients. When nutrient levels return to normal, healthy liver function is supported. By providing adequate levels of nutrition, SAMe assists in supporting liver health.
  • Histamine: The primary enzyme used to metabolize excessive histamine is called the Histamine N-methyltransferase (HNMT) enzyme. It relies on SAMe to pass a methyl group onto histamine. This changes histamine’s shape to support a healthy histamine response in the body.
  • COMT: SAMe is a cofactor for the COMT enzyme. Without adequate SAMe (as well as magnesium), your COMT enzyme cannot properly process dopamine and estrogens. Excess dopamine can lead to nervous feelings and irritability. Excess estrogens may cause cell damage. Providing your COMT enzyme with SAMe can support feelings of well-being and calm. It can also support healthy estrogen metabolite levels in your body.

SAMe by Seeking Health provides 250 mg of S-adenosyl-L-methionine (SAMe) per vegetarian-friendly capsule. To protect this vulnerable nutrient from being destroyed by stomach acid, SAMe has been encapsulated in acid-resistant capsules. The capsules are contained in a desiccated bottle to optimize their stability and prevent degradation from air and moisture. Experience the endless beneficial effects of SAMe today with SAMe capsules by Seeking Health.

Supplement Facts

Serving Size: 2 Capsules
Servings Per Container: 30

SAMe (S-adenosyl-L-methionine) 250 mg **
**Daily Value (DV) not established.

Other Ingredients: Acid-resistant capsule (hypromellose, gellan gum, and water), microcrystalline cellulose, ascorbyl palmitate, and silica.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Capsules
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use SAMe

Suggested Use

Take two capsules 45 minutes before or 60 minutes after a meal or as recommended by your healthcare provider. Taking away from food increases absorption.


Children and pregnant, lactating, or breastfeeding women should consult their healthcare professional prior to use. Do not use if tamper seal is damaged. If you are taking any medications for depression or anxiety, click here.

FAQs for SAMe

What is the purpose of each ingredient in SAMe?

Ingredients Purpose
SAMe (S-adenosyl-L-methionine) The body’s main methyl donor; Supports healthy mood, connective tissues, glutathione production, liver health, histamine metabolism, and methylation processes

Who is SAMe intended for?

SAMe is for those seeking healthy methylation support.

SAMe supports normal neurotransmitter synthesis and hormone metabolism. In turn, this supports feelings of calm and a positive mood.

Due to its role in histamine breakdown, SAMe is great for those seeking histamine metabolism support.

SAMe may also support bone and joint health due to its roles in healthy synthesis of connective tissues

How to use SAMe?

Take one capsule 45 minutes before or 60 minutes after a meal or as recommended by your healthcare professional. Taking away from food increases absorption.

Dr. Ben Lynch recommends ensuring adequate magnesium levels for an optimal experience with SAMe. Magnesium and SAMe are both cofactors for the COMT enzyme, needed to support normal dopamine breakdown. Those supplementing with SAMe, in particular those with slow COMT gene/enzyme function, may consider adding Optimal Magnesium to your SAMe regiment to support COMT function.

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What our customers say

Real reviews from real customers.

Rated 4.8 out of 5 stars
Based on 69 reviews
Total 5 star reviews: 63 Total 4 star reviews: 2 Total 3 star reviews: 2 Total 2 star reviews: 0 Total 1 star reviews: 2
94%would recommend this product
69 reviews
  • DS
    david s.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    4 days ago
    Just what I needed!

    I noticed a huge difference in my mood while taking this. Thanks for all the info shared!

  • LM
    Lisa M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 weeks ago

    I love the bogo, I have to take them daily having MTHFR. Great deal fast shipping

  • VM
    Vanessa M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    3 weeks ago

    After taking SAM-e, I feel like my body is lighter-more fluid! Hard to explain but I feel as if my system is "moving" not stagnant.

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