HomocysteX Plus - 60 Vegetarian Capsules

Retail: $27.95
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Quick Overview

HomocysteX Plus by Seeking Health supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism. This formula is exceptional for those with defective MTHFR genes. Taking just 5-MTHF is not sufficient for those with MTHFR mutations which is why Dr. Lynch provides a comprehensive complex to support normal levels of homocysteine and support the methylation cycle.

Product Description

HomocysteX by Seeking Health supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism. This formula is exceptional for those with defective MTHFR genes. Taking just 5-MTHF is not sufficient for those with MTHFR mutations which is why Dr. Lynch provides a comprehensive complex to support normal levels of homocysteine and support the methylation cycle.

Individuals most at increased risk for vitamin B12, folate, and vitamin B6 deficiencies are the elderly, vegetarians, and individuals with ulcers, Crohn's disease, and bacterial overgrowth. This dietary supplement may be especially beneficial for persons with impaired gastrointestinal absorptive function due to aging, illness, or surgery.

The body's methylation process is vital for formation of essential cell components such as proteins, nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes.* By transferring methyl groups (three hydrogen atoms bonded to a carbon atom, known as CH3) from one molecule to another, methylation turns on genes, activates enzymes, drives detoxification reactions, influences hormone secretion, and helps maintain normal metabolism of homocysteine, a potentially harmful amino acid metabolite.* Unfortunately, poor nutrition, oxidative stress, infections, metabolic defects, and various other factors can impair methylation processes throughout the body.* To nutritionally support optimal methylation capacity, this product supplies folate, vitamin B12, B6, B2, and betaine in amounts and forms that are efficiently utilized and well-tolerated by the body.

Key Benefits and Actions of HomocysteX Plus by Seeking Health:
  • Supports homocysteine metabolism
  • Supports cellular repair
  • Supports normal sleep cycles
  • Supports detoxification
  • Supports healthy energy output

Supplement Facts

Servings Size
1

Servings Per Container
60 Vegetarian Capsules

AMTDV
Riboflavin (as riboflavin-5-phosphate sodium) 25 mg 1471%
Vitamin B6 (as pyridoxal-5-phosphate) 15 mg 750%
Folate (as Quatrefolic (6S)-5-methyltetrahydrofolic acid, glucosamine salt) 800 mcg 200%
Vitamin B12 (as methylcobalamin, coenzyme B12) 1000 mcg 16667%
TMG (trimethylglycine) 700 mg **

 * = Daily Value Based on a standard 2,000 calorie daily intake
** = Daily Value Not Established

Suggested Use
1 capsule daily with food.

Ingredients
Riboflavin (as riboflavin-5-phosphate sodium), Vitamin B6 (as pyridoxal-5-phosphate), Folate (as Quatrefolic (6S)-5-methyltetrahydrofolic acid, glucosamine salt), Vitamin B12 (as methylcobalamin, coenzyme B12), TMG (trimethylglycine).

Other Ingredients
HPMC (capsule), ascorbyl palmitate, silica, medium chain triglycerides.

Warnings
Store in a cool, dry place (59-85 degrees) away from direct sunlight. Keep out of reach of children.

Capsule Size
#00 large vegetarian capsule

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Description

HomocysteX by Seeking Health supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism. This formula is exceptional for those with defective MTHFR genes. Taking just 5-MTHF is not sufficient for those with MTHFR mutations which is why Dr. Lynch provides a comprehensive complex to support normal levels of homocysteine and support the methylation cycle.

Individuals most at increased risk for vitamin B12, folate, and vitamin B6 deficiencies are the elderly, vegetarians, and individuals with ulcers, Crohn's disease, and bacterial overgrowth. This dietary supplement may be especially beneficial for persons with impaired gastrointestinal absorptive function due to aging, illness, or surgery.

The body's methylation process is vital for formation of essential cell components such as proteins, nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes.* By transferring methyl groups (three hydrogen atoms bonded to a carbon atom, known as CH3) from one molecule to another, methylation turns on genes, activates enzymes, drives detoxification reactions, influences hormone secretion, and helps maintain normal metabolism of homocysteine, a potentially harmful amino acid metabolite.* Unfortunately, poor nutrition, oxidative stress, infections, metabolic defects, and various other factors can impair methylation processes throughout the body.* To nutritionally support optimal methylation capacity, this product supplies folate, vitamin B12, B6, B2, and betaine in amounts and forms that are efficiently utilized and well-tolerated by the body.

Key Benefits and Actions of HomocysteX Plus by Seeking Health:
  • Supports homocysteine metabolism
  • Supports cellular repair
  • Supports normal sleep cycles
  • Supports detoxification
  • Supports healthy energy output

Supplement Facts

Servings Size
1

Servings Per Container
60 Vegetarian Capsules

AMTDV
Riboflavin (as riboflavin-5-phosphate sodium) 25 mg 1471%
Vitamin B6 (as pyridoxal-5-phosphate) 15 mg 750%
Folate (as Quatrefolic (6S)-5-methyltetrahydrofolic acid, glucosamine salt) 800 mcg 200%
Vitamin B12 (as methylcobalamin, coenzyme B12) 1000 mcg 16667%
TMG (trimethylglycine) 700 mg **

 * = Daily Value Based on a standard 2,000 calorie daily intake
** = Daily Value Not Established

Suggested Use
1 capsule daily with food.

Ingredients
Riboflavin (as riboflavin-5-phosphate sodium), Vitamin B6 (as pyridoxal-5-phosphate), Folate (as Quatrefolic (6S)-5-methyltetrahydrofolic acid, glucosamine salt), Vitamin B12 (as methylcobalamin, coenzyme B12), TMG (trimethylglycine).

Other Ingredients
HPMC (capsule), ascorbyl palmitate, silica, medium chain triglycerides.

Warnings
Store in a cool, dry place (59-85 degrees) away from direct sunlight. Keep out of reach of children.

Capsule Size
#00 large vegetarian capsule

Additional Information

Product Name HomocysteX Plus - 60 Vegetarian Capsules
Height 3.9
Width 2
Brand Seeking Health
UPC 828054145832
MPN HOMOP-60-CAPS
Age Adult
Delivery Vegetarian Capsule
Return Policy 60 Day Monday Back Guarantee
Weight Unit 0.15 lbs
SKU HOMOP-60-CAPS
Does not contain Gluten, Dairy, Egg, Soy, Fish, Shellfish, Nuts, Corn, GMO, Prebiotics
Retail Price $30.00

Product Questions

Questions on HomocysteX Plus - 60 Vegetarian Capsules

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  • MTHFR9/7/11 7:06 PM
    • I am Compound Heterozygous MTHFR and currently take Folbee. Should I take something like Homocystex instead?

      Thanks!
      Farrah
    • Hi Farrah - Compound heterozygous MTHFR - but which one? 677 C -> T or 1298 A -> C? Folbee contains the inferior forms of folic acid, B12 and B6. I do recommend the use of HomocysteX over Folbee for a few reasons: 1) HomocysteX contains all the most active forms of folic acid (5-MTHF), vitamin B12 (methylcobalamin) and vitamin B6 (pyridoxal-5-phosphate). 2) Soon HomocysteX, starting 9/22/2011, will also contain vitamin B2 (riboflavin-5-phosphate) and TMG (Betaine). These additional ingredients provide even further protection against homocysteine. 3) Homocystex is free of any food coloring, preservatives, dyes, chemicals and caking agents. Folbee contains quite a few of these which anyone with MTHFR should not be ingesting. I recommend taking 1-2 capsules of HomocysteX twice a day - breakfast and lunch. This way the blood levels of all the ingredients stay elevated longer. Taking only once a day is not as effective as B vitamins are water soluble so you simply urinate out the excess. I also recommend the use of Optimal Krill Oil and Flow Fx to further support a healthy cardiovascular system for those with MTHFR C677T mutations. In health, Dr Ben
    • Do you find this question helpful?  Yes   No
  • pregnancy12/1/11 6:09 PM
    • Can this product be taken if your pregnant? I just found out that I have the mthfr mutation today and I am 10 wks pregnant with 2nd child. Ist baby is 20 mo and healthy. I will be seeing a genetic specialist in the next few weeks. My mother has mthfr as well and is having many neurological issues mimicking alzheimers symptoms, she has had anxiety her whole life,is on a folic acid supplement but not sure exactly what it is. She has been on it for over a year and her sx are not improving. I have spina bifida occulta and anxiety. thank you.
    • Hello - I do not recommend HomocysteX while pregnant due to the high amount of TMG in it. Instead, consider L-5-MTHF http://www.seekinghealth.com/l-5-mthf.html Which MTHFR mutation do you have? There are other product recommendations which may be important to know but it depends on which MTHFR mutation you have. If you'd like to schedule a consult with me, please call 800-547-9812 and one of my team can schedule the consult for you. 45 minutes would provide a good starting point. Consults are prorated and $200/hr. If your mother is just taking folic acid, it is not doing much good. She needs to be taking a methylfolate and likely a methylcobalamin along with fish oil, arginine and niacin to name a few. A nattokinase supplement may be needed as well but hard to say without knowing more. We are getting in a sublingual methylfolate and methylcobalamin supplement soon. Please do check back for that in a couple weeks. For now, the L-5-MTHF is a good place to start. This removes the TMG which you cannot be taking at such high doses while pregnant. TMG is very safe and has not shown problems with pregnancy but it is best to avoid it at the amount found in HomocysteX. Best Dr Ben
    • Do you find this question helpful?  Yes   No
  • how much to take1/26/12 10:14 PM
    • I just started taking metanx 2 a day and wanted to switch to this. How many do I take? I have c677t x two. Thanks
    • Hello - Metanx contains a pretty potent amount of methylcobalamin, methylfolate and pyridoxal-5-phosphate. Metanx does not contain any TMG or riboflavin-5-phosphate yet Homocystex does. I recommend starting out with 2 capsules of HomocysteX in the morning before a meal and see how you feel. If you feel good for a few days, then increase to 2 capsules of HomocysteX in the morning and 2 capsules before lunch. Monitor how you feel. If you feel great, all set. Maintain this amount and stay on it long term. If you feel stiff, headache, nausea, then reduce the amount taken. Some find that they do very well if they take HomocysteX for 4 days on and 2 days off, some feel great on it daily, some don't feel great on it at all. Why is this? Why so much variation? It is because of varying toxicity levels of each individual. It is also because of other potential mutations which interact directly or indirectly with the MTHFR enzyme. I am developing a genetic test to help determine these other mutations for people so they can get a handle on improving their health. Best, Dr Ben
    • Do you find this question helpful?  Yes   No
  • Homocysteine4/4/12 8:13 AM
    • Just came upon your site & products.
      I am 70,in good health,active excerciser,but have High Homocysteine at 18.
      Have been taking B Vitamin and Folic supplements but can seem to get it down,even B12 shots.
      Was considering your Homocystex Plus,but should I be tested for MTHFR gene,
      or even if I had a defective gene you would still suggest Homocystex Plus.

      I was reading Cardiology Patient Page

      Homocysteine and MTHFR Mutations
      Relation to Thrombosis and Coronary Artery Disease
      Elizabeth A. Varga, MS; Amy C. Sturm, MS; Caron P. Misita, PharmD; Stephan Moll, MD in CIRCULATION

      who suggest...Folbee,Folgard or Foltx Combination Tablets.
      Is Homocystex better?

    • Hello - Certainly sounds like you may have the MTHFR defect. Regardless, HomocysteX Plus may help lower your homocysteine levels. Consider taking 1 capsule in the AM before breakfast and 1 more at lunch. Do this for about 1 week and then increase to 2 capsules before breakfast and 1 at lunch. Find the amount that works best for you. I highly recommend you pick up some Niacin as well just in case you get some side effects from having too many methyl groups. http://www.seekinghealth.com/niacin-100-tablets-seeking-health.html Read this: http://mthfr.net/methylfolate-side-effects/2012/03/01/ You may consider getting tested for the MTHFR defect by ordering this test: http://www.seekinghealth.com/mthfr-test.html Keep me posted how your homocysteine levels are doing ;) In health, Dr Ben
    • Do you find this question helpful?  Yes   No
  • HomosysteX Plus - dosage for child 4/12/12 1:14 PM
    • Hi Dr. Ben,

      My 9 yr. old son is heterozygous C677T. He is also just 43 lbs, small boned and no body fat. Testing has shown: signs of leaky gut - multiple food, seasonal, household sensitivites; G.I. pathogens - protozoa, bacteria, tapeworm, fluke, candida; chemical and heavy metal toxicity; cell salt imbalances, thyroid disturbance w/ T3 uptake on the high side... Symptomatically, he has occasional abdominal cramps, more frequent ankle/leg pain, and sometimes circles under eyes. But my smiley and huggable son plays baseball, piano, sings, is the family clown and is an artist deluxe. That's just a small picture of my sweet little guy.

      Now for my question: is your formula for HomosysteX or Plus suitable for my son, and if so, in what amounts? He is currently taking 1 sublingual B12 lozenge from Designs for Health containing 2000 mcg of B12 (hydroxocobalamin), 2 mg of B6 (pyridoxal-5-phosphate), and 800 mcg of folate (calcium folinate). He is also taking 2000 mcg of L-5-MTHF from Biotics Research in the a.m. before breakfast. He is almost out of both and I'm wondering if replacing these two with one of your combination supplements would serve his needs.

      Also, I read somewhere that taking ascorbic acid along with methycobalamin will destroy the methylcobalamin. Is that accurate information, and does Vit C in food form do the same?

      Thank you for all of your work in the MTHFR field. We are indebted to you for the readily available information and your knowledge base that you so selflessly share.

      ~Teresa
    • Hi Teresa - I think the formula of HomocysteX is too strong for your child. I am also thinking that the amount he is taking of the L-5-MTHF (2,000 mcg) is a lot for him. Is he showing signs of irritability, joint pain, insomnia, anxiety, depression? If so - there may be too much methylfolate on board. I'd like to see him taking instead a multivitamin that has methylfolate in it - such as Optimal Multivitamin Chewable. Consider having him take 1 to 2 tablets with breakfast and 1 tablet after school with a snack- or have him bring 1 tablet to school and have it with lunch. You are right that taking vitamin C alongside methylcobalamin can destroy the methylcobalamin when the vitamin C is in excess of 500 mg. Vitamin C in food - I doubt that occurs as food acts differently - but - it certainly may. I recommend replacing the sublingual B12 and methylfolate with the: - Optimal Multivitamin Chewable - 1-2 tablets with breakfast and 1 with lunch - Sublingual Active B12 with Metafolin - 1/2 tablet once daily - upon waking - to start. Increase to 1 full tablet after 1 week of seeing him respond favorably to this amount. To further support his digestion and overall nutrition: - ProBiota Sensitive - 1 capsule after dinner - Saccharomyces Boulardii - 1 capsule after dinner - Vitamin D360: 1 drop daily taken anytime - Optimal Vitamin C Powder: 1 scoop mixed in a water bottle and drunk throughout the day - not all at once. Microbial Defense may be useful as well - but I don't recommend starting that until you see the other things benefiting him. I do recommend he avoid: - dairy - wheat - and ideally gluten - but for now - wheat - limit sugar due to excessive yeast overgrowth Your son's MTHFR defect is not that severe so he should not need so much methylfolate. If he takes too much - it can really backfire and make him worse. Keep me posted how you are doing with him. If you get stuck, please do schedule a consult. In health, Dr Ben
    • Do you find this question helpful?  Yes   No
  • Is this right for me?4/25/12 7:52 PM
    • I found out today I am compound heterozygous. Have had 2 miscarriages in the last 7 months that were <8weeks. I have one healthy son, 2 years old. My ND suggested baby aspirin and Metagenic's Cardio B. From what I understand you don't recommend high dose Folic Acid. What should by my plan as I try to conceive, am pregnant, breastfeed, and then lifelong??
    • Hello - 

      This is a loaded question ;)

      I recommend you read this article on MTHFR.Net regarding Prenatal Supplementation with MTHFR.

      I absolutely do not recommend the use of folic acid in anyone with a MTHFR defect. Only methylfolate should be used - along with folinic acid at times (which may be obtained from leafy green vegetables and beans).

      In health,

      Dr Ben

    • Do you find this question helpful?  Yes   No
  • Bonnie4/28/12 11:23 AM
    • I am a 56 year old woman and recently learned I am homozgous for 677T.
      I have a Hx of breast cancer (11 years ago) and am currently treating cervical dysplasia (mild). This past year I have been on several rounds of antibiotics for bronchitis/pneumonia, sinusitis, and UTIs. I have some yeast problems. I have had mild depression and periods of low energy over the years.
      I am on a supplements to address the dysplasia; Vits C, D3, E, Fish Oil (no mercury), Cod Liver Oil,Tumeric, a Green Tea EGC supplement, high levels of Betacarotene (200,000 IU), a Probiotic (Nutirition Now PB-8), and recently started milk thistle.
      I have recently started your Basic protocol with Sublingual Active B12. However,
      I had already purchased Thorne-Methyl Guard, when I first learned I had 677C. (I am not taking it right now) and I am wondering if it would be reasonable to substitute the Methyl Guard for Homocystex Plus, with a low dose,gradually increasing it? I am trying to integrate your protocol with the regimen I already started for the dysplasia. Thank you for your help and any advice your are willing to offer.
    • Hi Bonnie - 

      If ok with your doctor, it is ok to substitute away from Methyl Guard to HomocysteX Plus - and start with a capsule or 1/2 capsule if you are sensitive. If you find you tolerate supplements well, starting with 1 tablet in the morning away from food should be fine for you. If you tolerate the 1 capsule of HomocysteX Plus well for 3 days, then consider taking another capsule away from food before lunch - around noon. If you continue to feel ok from this amount, then add in another capsule of HomocysteX Plus in the AM so taking 2 capsules in the AM. Basically, continue to add in another capsule of HomocysteX Plus every three to seven days until you find the amount that works well for you.

      In the event you feel 'off' from taking HomocysteX Plus, stop taking it for a day and you may have to take it some days - say every other day or take for 3 days and none for 2 days - you'll find what works best for you.

      Keep in mind the amount that works well for you will likely vary from week to week or month to month depending on how much methylation your body needs. Listen to your body and how you feel. It sounds difficult but it is easy if you are in tune and listening.

      Example - if you feel tired, a bit depressed and memory off, taking your usual amount of HomocysteX Plus will likely be good for you.

      If you feel anxious, irritated, have muscle pains, nausea, then taking HomocysteX Plus that day may set you off.

      Having a bottle of Neutralize on hand can help you with the detox reactions you may be experiencing from taking HomocysteX Plus. Consider taking a capsule of Neutralize if you experience any ill effects froom taking HomocysteX Plus. It will greatly help in alleviating those symptoms - especially if taking a 1/10th tablet of Niacin with it.

      Consider using ProBiota Woman to assist with your cervical dysplasia. Consider inserting one capsule vaginally in the evening for a month. ProBiota Woman may also be taken orally. It contains specific bacterial strains to help balance vaginal flora.

      In health,

      Dr Ben

    • Do you find this question helpful?  Yes   No
  • Heterozygous C677T no elevated homocysteine - Foltex4/29/12 8:29 PM
    • I just turned 40 and after having 10 pregnancies and only 3 live births, I pushed my OB do some testing to find out what was happening. I was just diagnosed with heterozygous C677T, homocysteine normal, which she says has little to do with my losses, but put me on Foltex "because it can't hurt". She said I could also supplement with OTC supplements if I preferred. From reading your site, this seems like it might not be the right option for me as the Folic Acid could simply build up in my system rather than methylate properly. Am I understanding that right? If so, which supplement would you recommend I start with, I am not really sure if the right one would be Homocystex, Plus or something else completely, but I really don't want to start the Foltx without more info. There does not seem to be any Dr. near Myrtle Beach, SC that specialize in this area.

      I am now working on getting my husband and children tested as well.

      Thanks!
    • Hello - 

      I am glad you are furthering your research in this area.

      Please read this article on Prenatal Supplementation with MTHFR.

      Also watch this presentation on MTHFR and Methylation - which is critical to understanding why you need to take methylfolate, methylcobalamin and how to take them.

      I recommend you consider starting out with:

      • Active B12 5000: start with 1/4 tablet and increase by 1/4 every 3 days until you feel you have enough on board. 
      • Subilngual Active B12 with Metafolin: start with 1/2 tablet and increase by 1/2 tablet every 7 days until you feel enough is on board. Take for 4 weeks. 
      • HomocysteX: if you do well with the Sublingual Active B12 with Metafolin, proceed to trying the HomocysteX. Stop the Sublingual Active B12 with Metafolin the day you start HomocysteX. Start HomcysteX with equivalent amounts of methylcobalamin and methylfolate you were taking in the tablet of Sublingual Active B12 with Methylfolate.

      You may need additional B12 so you may need to continue taking Active B12 5000 while taking HomocysteX. The only way to tell is by how you are feeling. Vitamin B12 is not toxic.

      I dont recommend taking HomocysteX Plus while pregnant due to the high level of Betaine (TMG) in it. Some betaine is ok but this is too much. 

      Taking HomocysteX, Active B12 or Sublingual Active B12 with Metafolin is ok.

      I do not recommend Foltex either due to the poor ingredients - not to mention the added coloring and other compounds in it.

      In health,

      Dr Ben

       

    • Do you find this question helpful?  Yes   No
  • Tested Positive for Both Copy's MTHFR /Methyl-Guard how to switch??5/9/12 1:55 PM
    • Hi Dr.Ben,
      I live In Gig Harbor, Washington.
      I am 44 years old just tested Positive for BOTH Copy's of MTHFR Gene. I am a female, 125, 5'5 and take NO meds. Eat organic,raise my own beef and cleanse alot. :)
      I started Methyl-Gaurd a month ago but had side effects....... is it too strong? I went off it and am now trying to dose at 1/2 capsule daily........ can I just switch to Homocystine X or what would you do if you were me?? :) I would love any thougts or help on my health :)

      I have had issues with bladder IC,Vaginitis, fatigue, and muscle soreness........

      Thank you for this site :)

    • Hi there -

      Appears that Methyl Guard is too strong for you.

      MTHFR mutations require that one really have a clean lifestyle, healthy diet and healthy digestive system. If either of those are out, then the MTHFR mutation 'activates'. Thus, in your situation, I'd be looking for the underlying causes of the IC and vaginitis, fatigue and muscle soreness. MTHFR may have some bearing here but definitely not all.

      I recommend working on the bladder and vaginitis first while at the same time addressing some components of fatigue and soreness. They are likely all related.

      A consult is highly recommended.

      Switching to HomocysteX from Methyl Guard is still not going to solve your problems - so I don't want to say switching is a better option. It is definitely less likely to cause side effects but it still won't heal as many things as I'd like to see healed ;)

      In health,

      Dr Ben

    • Do you find this question helpful?  Yes   No
  • TMG better on its own?6/14/12 10:52 AM
    • Hello,

      Is TMG better in a formula or on its own? Do you carry TMG by itself?
    • Hello - TMG is useful by itself when you want to know if it is good for you or not. Taking TMG in a complex formula makes it difficult to know if it is benefiting you. Seeking Health does not offer TMG alone currently - however, it is something we are considering. For now, what is recommended is to evaluate how you respond to various nutrients by building up on them one at a time. For example: - Active B12 5000: start with 1/5 tablet for a week skipping every other day. - Sublingual Active B12 with Metafolin: stop the Active B12 5000 and switch to this and take 1/2 tablet every AM or skip every other day for a week. - HomocysteX: stop the Sublingual Active B12 with Metafolin and switch to HomocysteX and take 1 capsule upon waking. Take daily or take every other day. - HomocysteX Plus: stop the HomocysteX and replace with HomocysteX Plus This way you are checking nutrient by nutrient and seeing how your body responds. NOTE: The suggested amounts are merely example starting points - they are not set in stone. Please discuss any and all dosages with your physician. In health, Dr Lynch
    • Do you find this question helpful?  Yes   No

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