Dirty Genes® - COMT Slow Support
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
Slow COMT activity may mean that you don’t have enough SAMe or too much homocysteine. Nutrients that support a balanced COMT gene include vitamin B12, other B vitamins, folate, and magnesium. Your MTHFR gene works closely with COMT, so you also need nutrients for methylation, like betaine and SAMe.
To support your slow COMT gene, you need supplementation that promotes the optimal way your gene should function. Hydrox-Adeno B12 and Folinic Acid provide bioavailable sources of vitamin B12 and folate in methyl-free versions, which might be easier to tolerate if you have a sensitive brain.
Explore other supportive nutrients for your COMT gene below, like Optimal Magnesium , Adrenal Support, or Optimal Sleep.

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Quench your body’s thirst for healthy hydration with the unique blend of ingredients found in the improved formula of Optimal Electrolyte!†
Optimal Electrolyte—Formulated with key ingredients, including sodium from real Himalayan pink salt and potassium, PeakATP®, niacin, and magnesium that easily mixes with water to support hydration for heart and muscle health.†
Best SellerImprovedOptimal Electrolyte
4.6Rated 4.6 out of 5 stars1,493 ReviewsFrom $38Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with PeakATP ®, HydroPrime ®, H...
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A convenient way to experience our electrolyte blend for healthy muscle contraction and relaxation and heart rhythm and contraction support. Each stick contains one serving of Optimal Electrolyte to mix with a glass of water.†
Best SellerOptimal Electrolyte Sticks
4.6Rated 4.6 out of 5 stars22 ReviewsFrom $40Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with key ingredients for hydrat...
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Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Magnesium Malate Powder
4.7Rated 4.7 out of 5 stars176 ReviewsFrom $22Key Benefits and Actions† Potent, powdered magnesium supplement Well-absorbed dimalate form of magnesium Supports healthy energy, muscles, nerve...
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Quench your body’s thirst for healthy hydration with the unique blend of ingredients found in the improved formula of Optimal Electrolyte!†
Optimal Electrolyte—Formulated with key ingredients, including sodium from real Himalayan pink salt and potassium, PeakATP®, niacin, and magnesium that easily mixes with water to support hydration for heart and muscle health.†
Best SellerImprovedOptimal Electrolyte
4.6Rated 4.6 out of 5 stars1,493 ReviewsFrom $38Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with PeakATP ®, HydroPrime ®, H...
View full details -
A convenient way to experience our electrolyte blend for healthy muscle contraction and relaxation and heart rhythm and contraction support. Each stick contains one serving of Optimal Electrolyte to mix with a glass of water.†
Best SellerOptimal Electrolyte Sticks
4.6Rated 4.6 out of 5 stars22 ReviewsFrom $40Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with key ingredients for hydrat...
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Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Magnesium Malate Powder
4.7Rated 4.7 out of 5 stars176 ReviewsFrom $22Key Benefits and Actions† Potent, powdered magnesium supplement Well-absorbed dimalate form of magnesium Supports healthy energy, muscles, nerve...
View full details
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Quench your body’s thirst for healthy hydration with the unique blend of ingredients found in the improved formula of Optimal Electrolyte!†
Optimal Electrolyte—Formulated with key ingredients, including sodium from real Himalayan pink salt and potassium, PeakATP®, niacin, and magnesium that easily mixes with water to support hydration for heart and muscle health.†
Best SellerImprovedOptimal Electrolyte
4.6Rated 4.6 out of 5 stars1,493 ReviewsFrom $38Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with PeakATP ®, HydroPrime ®, H...
View full details -
A convenient way to experience our electrolyte blend for healthy muscle contraction and relaxation and heart rhythm and contraction support. Each stick contains one serving of Optimal Electrolyte to mix with a glass of water.†
Best SellerOptimal Electrolyte Sticks
4.6Rated 4.6 out of 5 stars22 ReviewsFrom $40Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with key ingredients for hydrat...
View full details -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Magnesium Malate Powder
4.7Rated 4.7 out of 5 stars176 ReviewsFrom $22Key Benefits and Actions† Potent, powdered magnesium supplement Well-absorbed dimalate form of magnesium Supports healthy energy, muscles, nerve...
View full details
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Support the healthy conversion of fat into energy with Acetyl-L-Carnitine.†
Acetyl-L-carnitine—A unique, bioavailable amino acid that supports healthy energy production, brain and nervous system function, and fat metabolism.†

Acetyl-L-Carnitine
Key Benefits and Actions† Supports conversion of fat into energy Supports healthy heart, brain, muscle, and sperm function Supports athletic per...
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