Dirty Genes® - COMT Slow Support
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
Slow COMT activity may mean that you don’t have enough SAMe or too much homocysteine. Nutrients that support a balanced COMT gene include vitamin B12, other B vitamins, folate, and magnesium. Your MTHFR gene works closely with COMT, so you also need nutrients for methylation, like betaine and SAMe.
To support your slow COMT gene, you need supplementation that promotes the optimal way your gene should function. Hydrox-Adeno B12 and Folinic Acid provide bioavailable sources of vitamin B12 and folate in methyl-free versions, which might be easier to tolerate if you have a sensitive brain.
Explore other supportive nutrients for your COMT gene below, like Optimal Magnesium , Adrenal Support, or Optimal Sleep.

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Quench your body’s thirst for healthy hydration with the unique blend of ingredients found in the improved formula of Optimal Electrolyte!†
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Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
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4.8Rated 4.8 out of 5 stars182 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
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Get your daily dose of highly-concentrated omega-3s for cardiovascular and heart health support with Fish Oil.†
Fish Oil—Includes omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that support healthy joint function, normal body weight, normal inflammatory response, and healthy blood pressure.†
Fish Oil
5.0Rated 5.0 out of 5 stars129 ReviewsFrom $40Key Benefits and Actions† Burp-free, taste-free and easy to swallow 400 mg of DHA + 400 mg of EPA as triglycerides per softgel Wild caught...
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Feed your brain by supporting healthy mental energy, mood, concentration, and focus with Brain Nutrients.†
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4.6Rated 4.6 out of 5 stars1,493 ReviewsFrom $38Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with PeakATP ®, HydroPrime ®, H...
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Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars182 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
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Get your daily dose of highly-concentrated omega-3s for cardiovascular and heart health support with Fish Oil.†
Fish Oil—Includes omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that support healthy joint function, normal body weight, normal inflammatory response, and healthy blood pressure.†
Fish Oil
5.0Rated 5.0 out of 5 stars129 ReviewsFrom $40Key Benefits and Actions† Burp-free, taste-free and easy to swallow 400 mg of DHA + 400 mg of EPA as triglycerides per softgel Wild caught...
View full details -
Feed your brain by supporting healthy mental energy, mood, concentration, and focus with Brain Nutrients.†
Brain Nutrients—Designed to support a healthy, thriving brain with a unique blend of nutrients, including Emothion™ S-Acetyl-L-Glutathione, PeakATP®, and LifePQQ™.†
SaleBOGOBrain Nutrients
4.6Rated 4.6 out of 5 stars70 ReviewsFrom $50Provides energy and nutrition for your brain - quickly. Supports healthy mental energy, mood, concentration, and focus Enhances the effectiveness...
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Quench your body’s thirst for healthy hydration with the unique blend of ingredients found in the improved formula of Optimal Electrolyte!†
Optimal Electrolyte—Formulated with key ingredients, including sodium from real Himalayan pink salt and potassium, PeakATP®, niacin, and magnesium that easily mixes with water to support hydration for heart and muscle health.†
Best SellerImprovedOptimal Electrolyte
4.6Rated 4.6 out of 5 stars1,493 ReviewsFrom $38Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with PeakATP ®, HydroPrime ®, H...
View full details -
A convenient way to experience our electrolyte blend for healthy muscle contraction and relaxation and heart rhythm and contraction support. Each stick contains one serving of Optimal Electrolyte to mix with a glass of water.†
Best SellerOptimal Electrolyte Sticks
4.6Rated 4.6 out of 5 stars22 ReviewsFrom $40Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with key ingredients for hydrat...
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Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars182 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
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