Dirty Genes® - MTHFR Supplements
If you have an MTHFR gene SNP, you need supplementation that is bioavailable and doesn’t slow down your methylation processes. MTHFR (short for methylenetetrahydrofolate reductase) produces an enzyme that helps regulate how well your DNA methylation cycle works. Polymorphisms mean that MTHFR less efficiently converts folic acid (vitamin B9) and vitamin B12 to active forms.
If you have an MTHFR gene SNP, you need supplementation that is bioavailable and doesn’t slow down your methylation processes. MTHFR (short for methylenetetrahydrofolate reductase) produces an enzyme that helps regulate how well your DNA methylation cycle works. Polymorphisms mean that MTHFR less efficiently converts folic acid (vitamin B9) and vitamin B12 to active forms.
An impaired MTHFR gene can also lead to high homocysteine levels, detoxification challenges, and an increased risk for other problems.
For optimal health, you need bioavailable, methylated nutrients like methylcobalamin (methyl-B12), L-5-MTHF (methylfolate), SAMe, creatine, phosphatidylcholine, and more.
These work to support your body’s methylation processes by reducing the effort needed to activate them.
Your MTHFR gene mutation doesn’t have to confuse you. Get started with MTHFR supplements today. Try Seeking Health’s popular Optimal Multivitamin for comprehensive nutrient support. Or get HomocysteX Plus, which helps to support normal homocysteine conversion. B Complex Plus is a great way to support a healthy MTHFR enzyme.
Not sure where to start with a multivitamin? Use this chart to compare products.

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Promote sustainable energy by supporting methylation, homocysteine, and MTHFR with Methyl B12 with L-Methylfolate!†
Methyl B12 with L-Methylfolate—Each serving contains a blend of bioavailable folate and vitamin B12 to support healthy methylation, homocysteine regulation, and energy production in a tasty, well-absorbed lozenge.†
Best SellerMethyl B12 with L-Methylfolate
4.9Rated 4.9 out of 5 stars762 ReviewsFrom $25Key Benefits and Actions† Active, methylated folate and B12 in a well-absorbed lozenge Potent methylation, homocysteine, and MTHFR support Suppo...
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Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars182 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
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Support healthy energy production, oxidative stress, and aging responses with PQQ Lozenge!†
PQQ Lozenge—Contains 20 mg of Pyrroloquinoline Quinone Disodium Salt (PQQ), an antioxidant-like nutrient that supports healthy energy production and responses to oxidative stress.†
Best SellerPQQ Lozenge
4.7Rated 4.7 out of 5 stars298 ReviewsFrom $35Key Benefits and Actions† Healthy energy production support Healthy response to oxidative stress Supports healthy aging processes Who Needs PQQ...
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Promote sustainable energy by supporting methylation, homocysteine, and MTHFR with Methyl B12 with L-Methylfolate!†
Methyl B12 with L-Methylfolate—Each serving contains a blend of bioavailable folate and vitamin B12 to support healthy methylation, homocysteine regulation, and energy production in a tasty, well-absorbed lozenge.†
Best SellerMethyl B12 with L-Methylfolate
4.9Rated 4.9 out of 5 stars762 ReviewsFrom $25Key Benefits and Actions† Active, methylated folate and B12 in a well-absorbed lozenge Potent methylation, homocysteine, and MTHFR support Suppo...
View full details -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars182 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full details -
Support healthy energy production, oxidative stress, and aging responses with PQQ Lozenge!†
PQQ Lozenge—Contains 20 mg of Pyrroloquinoline Quinone Disodium Salt (PQQ), an antioxidant-like nutrient that supports healthy energy production and responses to oxidative stress.†
Best SellerPQQ Lozenge
4.7Rated 4.7 out of 5 stars298 ReviewsFrom $35Key Benefits and Actions† Healthy energy production support Healthy response to oxidative stress Supports healthy aging processes Who Needs PQQ...
View full details
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Promote sustainable energy by supporting methylation, homocysteine, and MTHFR with Methyl B12 with L-Methylfolate!†
Methyl B12 with L-Methylfolate—Each serving contains a blend of bioavailable folate and vitamin B12 to support healthy methylation, homocysteine regulation, and energy production in a tasty, well-absorbed lozenge.†
Best SellerMethyl B12 with L-Methylfolate
4.9Rated 4.9 out of 5 stars762 ReviewsFrom $25Key Benefits and Actions† Active, methylated folate and B12 in a well-absorbed lozenge Potent methylation, homocysteine, and MTHFR support Suppo...
View full details -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars182 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full details -
Support healthy energy production, oxidative stress, and aging responses with PQQ Lozenge!†
PQQ Lozenge—Contains 20 mg of Pyrroloquinoline Quinone Disodium Salt (PQQ), an antioxidant-like nutrient that supports healthy energy production and responses to oxidative stress.†
Best SellerPQQ Lozenge
4.7Rated 4.7 out of 5 stars298 ReviewsFrom $35Key Benefits and Actions† Healthy energy production support Healthy response to oxidative stress Supports healthy aging processes Who Needs PQQ...
View full details
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Support the healthy conversion of fat into energy with Acetyl-L-Carnitine.†
Acetyl-L-carnitine—A unique, bioavailable amino acid that supports healthy energy production, brain and nervous system function, and fat metabolism.†

Acetyl-L-Carnitine
Key Benefits and Actions† Supports conversion of fat into energy Supports healthy heart, brain, muscle, and sperm function Supports athletic per...
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