I have an MTHFR SNP and my integrative health practitioner recommended this as support. I am generally sensitive to some supplements and have had no adverse reactions. I can’t say I have noticed any “changes” for the good. Just glad it’s supporting me where I need it.
HomocysteX Plus by Seeking Health supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TMG) to synergistically support methylation and normal homocysteine metabolism. Methylation is vital for formation of essential cell components such as proteins, nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes. By transferring methyl groups (three hydrogen atoms bonded to a carbon atom, known as CH3) from one molecule to another, methylation turns on genes, activates enzymes, drives detoxification reactions, influences hormone secretion, and helps maintain normal metabolism of homocysteine, a potentially harmful amino acid metabolite. Unfortunately, poor nutrition, oxidative stress, infections, metabolic defects, and various other factors can impair methylation processes throughout the body.*
To nutritionally support optimal methylation capacity, this product supplies folate, vitamin B12, B6, B2, and betaine in amounts and forms that are efficiently utilized and well-tolerated by the body. Taking just L-5-methylfolate is often times not sufficient for those with MTHFR mutations. Dr. Lynch provides these other ingredients, such as betaine (TMG), to help support healthy homocysteine levels and support the methylation cycle.*
Betaine is a powerful and important methyl donor for the body, especially for those who have MTHFR mutations. Vitamin B12 is crucial to the formation of healthy red blood cells, energy production, nervous system support, cognitive function, and homocysteine regulation. Vitamin B6 as P-5-P is important as a coenzyme for the normal metabolism of amino acids, carbohydrates and lipids. It is also involved in healthy cognitive development, immune health and homocysteine conversion. Riboflavin is important for body growth and red blood cell production and assists in the process of releasing energy from carbohydrates.*
For a methylation support supplement without the betaine, consider our HomocysteX. For a B12- and folate-only product, consider our Active B12 with L-5-MTHF.
Suitable for Vegans and Vegetarians
Milk, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat, Soy, Gluten, GMO, Artificial Colors, Artificial Flavors
Take 1 capsule daily with or without food, or as directed by your healthcare professional. Do not take within 5 hours of bedtime as it may interfere with sleep.
Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. Consult with a healthcare professional before use if you are using antibiotics or other medications.
Serving Size: 1 Capsule
Servings Per Container: 60
|Riboflavin (as riboflavin-5’-phosphate sodium)||25 mg||1,923%|
|Vitamin B6 (as pyridoxal-5’-phosphate)||15 mg||882%|
|Folate [as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt]||1,360 mcg DFE (800 mcg)||340%|
|Vitamin B12 (as MECOBALACTIVE® methylcobalamin and adenosylcobalamin)||1,000 mcg||41,667%|
|TMG (trimethylglycine)||700 mg||**|
|**Daily Value (DV) not established.|
Other Ingredients: Vegetarian capsule (hypromellose and water) and ascorbyl palmitate.
Quatrefolic® is a registered trademark of Gnosis S.p.A. Produced under US Patent 7,947,662.
MECOBALACTIVE® is a registered trademark of HealthTech BioActives SLU d.b.a. Ferrer HealthTech.
|Learning Center||Find product FAQ and more! Click here.|
|Cost Per Serving||$0.47|
|Delivery Method||Vegetarian Capsule|
|Storage||Keep closed in a cool, dry place out of reach by children.|
|Dimensions (in.)||Length: 2 / Width: 2 / Height: 3.75|
|Return Policy||Learn more about our Return Policy.|
MTHFR Gene Mutation
According to my Strate Gene report I have the MTHFR gene mutation so decided to try this and see if it made a difference. The first couple days taking it I felt "wired". I've been taking it now for a couple weeks and it seems the symptoms have calmed down, and I don't take it every day now.
Having the MTHFR Gene mutation has had a very negative affect on my health. I have been self injecting a vitamin B complex with Amino Acids at 1cc every week for over 10+ years. Recently, from my bloodwork from the Dr who prescribes this for me found that I was falling very low and upped me to 2cc every week. It's getting crazy expensive! My Dr recommended Seeking Health and I purchased the Homocystex Plus! Boy can I tell a major difference! I have much more energy, clarity and focus. I'm still taking my injections for now but I'm praying that i will be able to come off of that someday soon. But I am so thankful for the huge difference the Homocystex Plus is making for my everyday life!
Recommended by my D.O.
I have both MTHFR variants and my D.O. recommended this supplement. Seems to work great, no side effects, and over time I can see the benefits.