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B Complex Plus

  • Healthy energy production support
  • Supports normal hormone balance and mood
  • Supports healthy methylation and homocysteine levels
This formula contains niacin. When taken on an empty stomach, a healthy response to niacin supplementation may include mild blushing, warming, or tingling of the skin. See below for more details.

Who Needs B Complex Plus

Did you know that you need B vitamins every day?

That’s because your body doesn’t store these water-soluble vitamins.

Nearly every biochemical process in your body is in some way dependent upon B vitamins.

There are eight B vitamins considered essential because your body cannot make them. Vegan and vegetarian diets tend to be lower in some of these essential nutrients. Those with certain genetic mutations, such as MTHFR or MTRR variations, may have difficulty obtaining them from food alone. Without adequate B vitamins, you might be struggling with low energy levels, elevated homocysteine levels, and inadequate methylation.

B Complex Plus is a potent vitamin B complex supplement. It provides active forms of the 8 essential B vitamins plus choline for additional methylation support.

B Complex Plus is an excellent option if you’re looking for a high-strength, one-a-day B complex dietary supplement. It contains over 100% of the daily value for all eight essential B vitamins. This formulation is ideal for those who are deficient or are looking for higher levels of B vitamins in their supplement.

B Complex Plus includes 680 mcg DFE (400 mcg) of the active, methylated form of folate. Active folate is known as 5-methyltetrahydrofolate (5-MTHF). It is the only form of folate that crosses the blood-brain barrier. It supports MTHFR gene variations and healthy methylation throughout your body.

Folic acid is never included in any Seeking Health dietary supplements. This artificial version of folate is not well utilized by the body. It can even contribute to folate deficiency and other adverse side effects!

B Complex Plus also includes 50 mcg of vitamin B12 in the bioavailable forms of methylcobalamin and adenosylcobalamin. Here at Seeking Health, you’ll never find the cyanide-containing form of B12 known as cyanocobalamin. Before being used, your liver must first convert it into an active form and discard the cyanide. It appears that methylcobalamin may be a gentler option that the body can use more efficiently than cyanocobalamin.

Bioavailable forms of B vitamins promote healthy:

  • Immune system function
  • Energy production
  • Hormone balance
  • Positive mood
  • Nerves and brain
  • Red blood cells
  • Homocysteine levels

Choline is a source of methyl groups. It is included in this super B-complex to support methylation. It appears to play key roles in healthy nervous system and brain function, liver and heart health, and cell membrane formation.

B Complex Plus contains potent amounts of your daily essential B vitamins in bioactive forms plus choline. This formula is gluten-free and free of GMO markers. It is ideal for those experiencing deficiency or in need of higher amounts of B vitamins. It supports a healthy methylation pathway and nearly every biochemical process in your body.

Get ready to tackle the day with this powerful, energy-supporting formula!

Customer Review

Excellent Quality and Value

I switched to this B complex from another brand due to a recent micronutrient panel that gave me targeted information on which B vitamins I was most in need of. I trust Seeking Health to always have the very best quality, and found this supplement to provide a very balanced ratio. ~El

Key Ingredients In B Complex Plus

  • Folate: Vitamin B9 is provided in its active form of methylated folate (5-MTHF). This form of folate supports healthy homocysteine conversion, DNA repair, methylation processes, and epigenetic expression. It also helps to replenish folate levels that are lost due to a slow MTHFR gene and folate pathway.
  • Vitamin B12: Two active forms of B12 (methylcobalamin and adenosylcobalamin) support healthy energy production and methylation processes. Active B12 promotes healthy homocysteine levels by aiding its conversion to methionine via the MTR enzyme.
  • Riboflavin: Vitamin B2 is a cofactor for the MTHFR gene, which produces the active form of folate. Riboflavin supports healthy MTRR and MTHFR enzyme activity, hormone balance, and nervous system function. Riboflavin also plays a crucial role in cellular energy production.
  • Niacin: Vitamin B3 supports healthy circulation, MTRR enzyme function, and energy production.
  • Vitamin B6: Pyridoxine as P-5-P supports healthy hormone and neurotransmitter balance. P-5-P is a cofactor for the CBS enzyme, needed for healthy homocysteine metabolism and glutathione formation.
  • Thiamin: Vitamin B1 supports healthy carbohydrate metabolism and detoxification.
  • Biotin: Supports healthy skin and nails.
  • Pantothenic Acid: Adrenal health support.
  • Choline: Supports liver and brain health. Choline is needed to create healthy phosphatidylcholine levels via the CEPT1 enzyme.

Why B Complex Plus Works

Without B vitamins, hundreds of cellular reactions could not take place. Amongst many things, B vitamins are frequently used as coenzymes. They help power the enzymes that metabolize food into cellular energy (ATP) and regulate the methylation cycle.

For example, a significant enzyme complex transforms glucose into ATP called the Pyruvate Dehydrogenase Complex. Embedded in this important group of proteins are various B vitamins. They pass pyruvate along, facilitating its transformation into acetyl CoA, which enters the Krebs cycle to generate energy (ATP). Vitamins B1 (thiamin), B2 (riboflavin), B3 (niacin), and B5 (pantothenic acid) all play crucial roles in transforming glucose from food into energy used to power us throughout the day.

When it is time to rest, digest, detox, and repair, our methylation cycle helps to produce melatonin, dopamine, bile, and phosphatidylcholine. To function optimally, methylation cycle enzymes depend on vitamins B2 (riboflavin), B6 (pyridoxine), B9 (folates), B12 (cobalamins), and choline. Methylation enzymes/proteins cannot achieve the correct shape needed to facilitate healthy sleep, mood, digestion, and cellular repair if these critical nutrients are missing.

There are thousands of processes occurring in your body every second that could not happen without the help of the essential B vitamins. B Complex Plus provides all of the essentials plus choline. The potent levels and biologically active forms found in B Complex Plus support your enzymes and cells to function optimally.

B Complex Plus
Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 100

Thiamin (as thiamine hydrochloride) 25 mg 2,083%
Riboflavin (as riboflavin 5'-phosphate sodium) 20 mg 1,538%
Niacin (as inositol hexanicotinate and niacin) 95 mg 594%
Vitamin B6 (as pyridoxal 5'-phosphate) 20 mg 1,176%
Folate [as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt and calcium folinate] 680 mcg DFE (400 mcg) 170%
Vitamin B12 (as MECOBALACTIVE® methylcobalamin and adenosylcobalamin) 50 mcg 2,083%
Biotin 750 mcg 2,500%
Pantothenic Acid (as d-calcium pantothenate) 125 mg 2,500%
Choline (as choline bitartrate) 50 mg 9%
DV = Daily Value

Other Ingredients: Vegetarian capsule (hypromellose and water), microcrystalline cellulose, ascorbyl palmitate, and silica.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Capsules
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use B Complex Plus

Suggested Use

As needed, take 1 capsule daily with food or as directed by your healthcare professional. Do not take within 5 hours of bedtime as it may interfere with sleep.


Consult with your healthcare practitioner prior to use. Do not use if inner tamper seal is damaged.

Suitable for


Delivery Method


How to Store

Keep closed in a cool, dry place out of reach by children.

Niacin Flushing: This formula contains niacin. When taken on an empty stomach, a healthy response to niacin supplementation may include mild blushing, warming, or tingling of the skin. This can appear on the ears, face, arms, torso, or occasionally on the legs. Commonly referred to as a "niacin flush", this harmless response normally dissipates within an hour. It is related to niacin's role in vasodilation (widening of blood vessels). Vasodilation leads to better circulation, capillary flushing, and increased blood flow to the surface of the skin. To minimize or prevent flushing, consider taking this supplement with food or in divided doses.

FAQs for B Complex Plus

What is the purpose of each ingredient in B Complex Plus?

Ingredients Purpose
Thiamin Supports healthy carbohydrate metabolism and nervous system function
Niacin Supports healthy energy levels, skin, and metabolism
Biotin Supports healthy carbohydrate metabolism, skin, hair, and nails
Pantothenic Acid Supports healthy inflammatory processes and adrenal function
Choline Supports healthy brain, liver, and cell walls
Riboflavin Supports cellular health; Is a key component in cellular energy production; Acts as a cofactor for many genes in the folate pathway, including MTHFR; Supports healthy methylation
Vitamin B6 (as pyridoxal 5’-phosphate) Supports normal metabolism of amino acids, carbohydrates, and proteins; Acts as a cofactor for the CBS gene, which processes homocysteine and supports glutathione production
Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt and calcium folinate) Supports healthy methylation, blood cells, and mood
Vitamin B12 (as methylcobalamin and adenosylcobalamin) Supports healthy homocysteine levels, energy production, cognition, and red blood cell formation

Who is B Complex Plus intended for?

B Complex Plus provides all eight essential B vitamins in potent doses to support deficiencies, diets lacking in B vitamins (vegan or vegetarian diets), or those needing comprehensive methylation pathway support.

How to use B Complex Plus?

Take 1 capsule daily with food or as directed by your healthcare professional. Do not take within 5 hours of bedtime as it may interfere with sleep.

Which B Complex is right for me?

Check out this B Complex Supplement Comparison Chart.

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What our customers say

Real reviews from real customers.

Rated 4.9 out of 5 stars
Based on 369 reviews
Total 5 star reviews: 335 Total 4 star reviews: 27 Total 3 star reviews: 3 Total 2 star reviews: 3 Total 1 star reviews: 1
98%would recommend this product
369 reviews
  • PG
    Pamela G.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    B complex plus

    I really like it. It helps me so much with my CNS.

  • TP
    Tammy P.
    Verified Buyer
    I recommend this product
    Rated 4 out of 5 stars
    2 days ago
    Can’t think clearly without it

    Love this stuff, I definitely notice when I run out because I have more word finding difficulties without it. I took one star off because I feel like it’s too expensive, but c’est la vie.

  • A Profile picture for Andrea
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    4 days ago

    My daughter is using this to support methylation with great results.

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