Dirty Genes® - MTHFR Supplements
If you have an MTHFR gene SNP, you need supplementation that is bioavailable and doesn’t slow down your methylation processes. MTHFR (short for methylenetetrahydrofolate reductase) produces an enzyme that helps regulate how well your DNA methylation cycle works. Polymorphisms mean that MTHFR less efficiently converts folic acid (vitamin B9) and vitamin B12 to active forms.
If you have an MTHFR gene SNP, you need supplementation that is bioavailable and doesn’t slow down your methylation processes. MTHFR (short for methylenetetrahydrofolate reductase) produces an enzyme that helps regulate how well your DNA methylation cycle works. Polymorphisms mean that MTHFR less efficiently converts folic acid (vitamin B9) and vitamin B12 to active forms.
An impaired MTHFR gene can also lead to high homocysteine levels, detoxification challenges, and an increased risk for other problems.
For optimal health, you need bioavailable, methylated nutrients like methylcobalamin (methyl-B12), L-5-MTHF (methylfolate), SAMe, creatine, phosphatidylcholine, and more.
These work to support your body’s methylation processes by reducing the effort needed to activate them.
Your MTHFR gene mutation doesn’t have to confuse you. Get started with MTHFR supplements today. Try Seeking Health’s popular Optimal Multivitamin for comprehensive nutrient support. Or get HomocysteX Plus, which helps to support normal homocysteine conversion. B Complex Plus is a great way to support a healthy MTHFR enzyme.
Not sure where to start with a multivitamin? Use this chart to compare products.

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Get all-in-one health support with the specially formulated blend of nutrients found in Optimal Man™!†
Optimal Man™—A complete multivitamin/multimineral containing supportive herbs with antioxidant properties to support healthy testosterone levels and men’s health and fertility.†
Best SellerOptimal Man™
4.8Rated 4.8 out of 5 stars128 ReviewsFrom $65Key Benefits and Actions† Supports men’s health and male fertility Supports healthy testosterone levels Supports healthy cognition, energy, and ...
View full details -
Keep your homocysteine levels in check with the unique formula found in Homocysteine Nutrients!†
Homocysteine Nutrients—Provides the 5 nutrients your body requires for optimal methylation, including folate, methylcobalamin, and adenosylcobalamin, to support normal homocysteine breakdown for heart health support.†
Best SellerHomocysteine Nutrients
4.9Rated 4.9 out of 5 stars262 ReviewsFrom $35Key Benefits and Actions† Supports healthy methylation and homocysteine levels Powerful heart health support Supports healthy cognition and brai...
View full details -
Start your kids’ day off right with great-tasting and sugar-free Kids Multivitamin Chewable!
Kids Multivitamin Chewable—A comprehensive kids’ multivitamin and multimineral that supports their growth, genes, and important pathways in a tasty, kid-approved chewable.†
Out of Stock ImprovedKids Multivitamin Chewable
4.6Rated 4.6 out of 5 stars52 ReviewsFrom $30Great-tasting, kid-approved and sugar-free Supports kids from 4 years old and up Comprehensive kid’s multivitamin and multimineral During your...
View full details -
Support normal hormone balance, a balanced mood, and healthy energy production with B Complex Plus.†
B Complex Plus—A potent vitamin B complex supplement that provides active forms of the 8 essential B vitamins plus choline for additional methylation support.†
Best SellerB Complex Plus
4.9Rated 4.9 out of 5 stars431 ReviewsFrom $30Key Benefits and Actions† Healthy energy production support Supports normal hormone balance and mood Supports healthy methylation and homocystei...
View full details -
Rest easy knowing you’re giving your body and unborn baby the best prenatal support with Optimal Prenatal!†
Optimal Prenatal—A comprehensive blend designed by Dr. Ben Lynch that includes 38 researched ingredients to support healthy fertility, pregnancy, breastfeeding, and comfort when experiencing nausea.†
Best SellerOptimal Prenatal
4.8Rated 4.8 out of 5 stars996 ReviewsFrom $65Benefits and Actions† High-strength prenatal formula supports healthy spine and brain development Digestive comfort from vitamin B6 and ginger B...
View full details -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars183 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full details -
Get your daily dose of highly-concentrated omega-3s for cardiovascular and heart health support with Fish Oil.†
Fish Oil—Includes omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that support healthy joint function, normal body weight, normal inflammatory response, and healthy blood pressure.†
Fish Oil
5.0Rated 5.0 out of 5 stars129 ReviewsFrom $40Key Benefits and Actions† Burp-free, taste-free and easy to swallow 400 mg of DHA + 400 mg of EPA as triglycerides per softgel Wild caught...
View full details -
Promote sustainable energy by supporting methylation, homocysteine, and MTHFR with Methyl B12 with L-Methylfolate!†
Methyl B12 with L-Methylfolate—Each serving contains a blend of bioavailable folate and vitamin B12 to support healthy methylation, homocysteine regulation, and energy production in a tasty, well-absorbed lozenge.†
Best SellerMethyl B12 with L-Methylfolate
4.9Rated 4.9 out of 5 stars762 ReviewsFrom $25Key Benefits and Actions† Active, methylated folate and B12 in a well-absorbed lozenge Potent methylation, homocysteine, and MTHFR support Suppo...
View full details -
Quench your body’s thirst for healthy hydration with the unique blend of ingredients found in the improved formula of Optimal Electrolyte!†
Optimal Electrolyte—Formulated with key ingredients, including sodium from real Himalayan pink salt and potassium, PeakATP®, niacin, and magnesium that easily mixes with water to support hydration for heart and muscle health.†
Best SellerImprovedOptimal Electrolyte
4.6Rated 4.6 out of 5 stars1,497 ReviewsFrom $38Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with PeakATP ®, HydroPrime ®, H...
View full details -
Start your day off right by giving your overall health and well-being top priority with Multivitamin One!†
Multivitamin One—A one-day multivitamin containing active forms of your essential daily nutrients in a well-absorbed capsule formulated without vitamin C, magnesium, calcium, or iron to allow customization.†
Best SellerMultivitamin One
4.8Rated 4.8 out of 5 stars373 ReviewsFrom $35Key Benefits and Actions† One-a-day multivitamin featuring bioavailable nutrients Methyl B12 and methylfolate support optimal methylation Powerf...
View full details -
A convenient way to experience our electrolyte blend for healthy muscle contraction and relaxation and heart rhythm and contraction support. Each stick contains one serving of Optimal Electrolyte to mix with a glass of water.†
Best SellerOptimal Electrolyte Sticks
4.7Rated 4.7 out of 5 stars26 ReviewsFrom $40Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with key ingredients for hydrat...
View full details -
Promote the healthy development of your baby’s brain, spinal cord, and immune system while supporting your pregnancy health with Prenatal Essentials!†
Prenatal Essentials—Contains only the essential nutrients you need in superior and bioavailable forms, including folinic acid, bioactive B12, and chelated minerals for targeted pregnancy support.†
Best SellerPrenatal Essentials
4.8Rated 4.8 out of 5 stars443 ReviewsFrom $35Key Benefits and Actions† 2-capsule serving size provides your prenatal vitamin essentials Bioavailable B12 and folate support healthy methylati...
View full details
-
Get all-in-one health support with the specially formulated blend of nutrients found in Optimal Man™!†
Optimal Man™—A complete multivitamin/multimineral containing supportive herbs with antioxidant properties to support healthy testosterone levels and men’s health and fertility.†
Best SellerOptimal Man™
4.8Rated 4.8 out of 5 stars128 ReviewsFrom $65Key Benefits and Actions† Supports men’s health and male fertility Supports healthy testosterone levels Supports healthy cognition, energy, and ...
View full details -
Keep your homocysteine levels in check with the unique formula found in Homocysteine Nutrients!†
Homocysteine Nutrients—Provides the 5 nutrients your body requires for optimal methylation, including folate, methylcobalamin, and adenosylcobalamin, to support normal homocysteine breakdown for heart health support.†
Best SellerHomocysteine Nutrients
4.9Rated 4.9 out of 5 stars262 ReviewsFrom $35Key Benefits and Actions† Supports healthy methylation and homocysteine levels Powerful heart health support Supports healthy cognition and brai...
View full details -
Start your kids’ day off right with great-tasting and sugar-free Kids Multivitamin Chewable!
Kids Multivitamin Chewable—A comprehensive kids’ multivitamin and multimineral that supports their growth, genes, and important pathways in a tasty, kid-approved chewable.†
Out of Stock ImprovedKids Multivitamin Chewable
4.6Rated 4.6 out of 5 stars52 ReviewsFrom $30Great-tasting, kid-approved and sugar-free Supports kids from 4 years old and up Comprehensive kid’s multivitamin and multimineral During your...
View full details -
Support normal hormone balance, a balanced mood, and healthy energy production with B Complex Plus.†
B Complex Plus—A potent vitamin B complex supplement that provides active forms of the 8 essential B vitamins plus choline for additional methylation support.†
Best SellerB Complex Plus
4.9Rated 4.9 out of 5 stars431 ReviewsFrom $30Key Benefits and Actions† Healthy energy production support Supports normal hormone balance and mood Supports healthy methylation and homocystei...
View full details -
Rest easy knowing you’re giving your body and unborn baby the best prenatal support with Optimal Prenatal!†
Optimal Prenatal—A comprehensive blend designed by Dr. Ben Lynch that includes 38 researched ingredients to support healthy fertility, pregnancy, breastfeeding, and comfort when experiencing nausea.†
Best SellerOptimal Prenatal
4.8Rated 4.8 out of 5 stars996 ReviewsFrom $65Benefits and Actions† High-strength prenatal formula supports healthy spine and brain development Digestive comfort from vitamin B6 and ginger B...
View full details -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars183 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full details -
Get your daily dose of highly-concentrated omega-3s for cardiovascular and heart health support with Fish Oil.†
Fish Oil—Includes omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that support healthy joint function, normal body weight, normal inflammatory response, and healthy blood pressure.†
Fish Oil
5.0Rated 5.0 out of 5 stars129 ReviewsFrom $40Key Benefits and Actions† Burp-free, taste-free and easy to swallow 400 mg of DHA + 400 mg of EPA as triglycerides per softgel Wild caught...
View full details -
Promote sustainable energy by supporting methylation, homocysteine, and MTHFR with Methyl B12 with L-Methylfolate!†
Methyl B12 with L-Methylfolate—Each serving contains a blend of bioavailable folate and vitamin B12 to support healthy methylation, homocysteine regulation, and energy production in a tasty, well-absorbed lozenge.†
Best SellerMethyl B12 with L-Methylfolate
4.9Rated 4.9 out of 5 stars762 ReviewsFrom $25Key Benefits and Actions† Active, methylated folate and B12 in a well-absorbed lozenge Potent methylation, homocysteine, and MTHFR support Suppo...
View full details -
Quench your body’s thirst for healthy hydration with the unique blend of ingredients found in the improved formula of Optimal Electrolyte!†
Optimal Electrolyte—Formulated with key ingredients, including sodium from real Himalayan pink salt and potassium, PeakATP®, niacin, and magnesium that easily mixes with water to support hydration for heart and muscle health.†
Best SellerImprovedOptimal Electrolyte
4.6Rated 4.6 out of 5 stars1,497 ReviewsFrom $38Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with PeakATP ®, HydroPrime ®, H...
View full details -
Start your day off right by giving your overall health and well-being top priority with Multivitamin One!†
Multivitamin One—A one-day multivitamin containing active forms of your essential daily nutrients in a well-absorbed capsule formulated without vitamin C, magnesium, calcium, or iron to allow customization.†
Best SellerMultivitamin One
4.8Rated 4.8 out of 5 stars373 ReviewsFrom $35Key Benefits and Actions† One-a-day multivitamin featuring bioavailable nutrients Methyl B12 and methylfolate support optimal methylation Powerf...
View full details -
A convenient way to experience our electrolyte blend for healthy muscle contraction and relaxation and heart rhythm and contraction support. Each stick contains one serving of Optimal Electrolyte to mix with a glass of water.†
Best SellerOptimal Electrolyte Sticks
4.7Rated 4.7 out of 5 stars26 ReviewsFrom $40Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with key ingredients for hydrat...
View full details -
Promote the healthy development of your baby’s brain, spinal cord, and immune system while supporting your pregnancy health with Prenatal Essentials!†
Prenatal Essentials—Contains only the essential nutrients you need in superior and bioavailable forms, including folinic acid, bioactive B12, and chelated minerals for targeted pregnancy support.†
Best SellerPrenatal Essentials
4.8Rated 4.8 out of 5 stars443 ReviewsFrom $35Key Benefits and Actions† 2-capsule serving size provides your prenatal vitamin essentials Bioavailable B12 and folate support healthy methylati...
View full details
-
Get all-in-one health support with the specially formulated blend of nutrients found in Optimal Man™!†
Optimal Man™—A complete multivitamin/multimineral containing supportive herbs with antioxidant properties to support healthy testosterone levels and men’s health and fertility.†
Best SellerOptimal Man™
4.8Rated 4.8 out of 5 stars128 ReviewsFrom $65Key Benefits and Actions† Supports men’s health and male fertility Supports healthy testosterone levels Supports healthy cognition, energy, and ...
View full details -
Keep your homocysteine levels in check with the unique formula found in Homocysteine Nutrients!†
Homocysteine Nutrients—Provides the 5 nutrients your body requires for optimal methylation, including folate, methylcobalamin, and adenosylcobalamin, to support normal homocysteine breakdown for heart health support.†
Best SellerHomocysteine Nutrients
4.9Rated 4.9 out of 5 stars262 ReviewsFrom $35Key Benefits and Actions† Supports healthy methylation and homocysteine levels Powerful heart health support Supports healthy cognition and brai...
View full details -
Start your kids’ day off right with great-tasting and sugar-free Kids Multivitamin Chewable!
Kids Multivitamin Chewable—A comprehensive kids’ multivitamin and multimineral that supports their growth, genes, and important pathways in a tasty, kid-approved chewable.†
Out of Stock ImprovedKids Multivitamin Chewable
4.6Rated 4.6 out of 5 stars52 ReviewsFrom $30Great-tasting, kid-approved and sugar-free Supports kids from 4 years old and up Comprehensive kid’s multivitamin and multimineral During your...
View full details -
Support normal hormone balance, a balanced mood, and healthy energy production with B Complex Plus.†
B Complex Plus—A potent vitamin B complex supplement that provides active forms of the 8 essential B vitamins plus choline for additional methylation support.†
Best SellerB Complex Plus
4.9Rated 4.9 out of 5 stars431 ReviewsFrom $30Key Benefits and Actions† Healthy energy production support Supports normal hormone balance and mood Supports healthy methylation and homocystei...
View full details -
Rest easy knowing you’re giving your body and unborn baby the best prenatal support with Optimal Prenatal!†
Optimal Prenatal—A comprehensive blend designed by Dr. Ben Lynch that includes 38 researched ingredients to support healthy fertility, pregnancy, breastfeeding, and comfort when experiencing nausea.†
Best SellerOptimal Prenatal
4.8Rated 4.8 out of 5 stars996 ReviewsFrom $65Benefits and Actions† High-strength prenatal formula supports healthy spine and brain development Digestive comfort from vitamin B6 and ginger B...
View full details -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars183 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full details -
Get your daily dose of highly-concentrated omega-3s for cardiovascular and heart health support with Fish Oil.†
Fish Oil—Includes omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that support healthy joint function, normal body weight, normal inflammatory response, and healthy blood pressure.†
Fish Oil
5.0Rated 5.0 out of 5 stars129 ReviewsFrom $40Key Benefits and Actions† Burp-free, taste-free and easy to swallow 400 mg of DHA + 400 mg of EPA as triglycerides per softgel Wild caught...
View full details -
Promote sustainable energy by supporting methylation, homocysteine, and MTHFR with Methyl B12 with L-Methylfolate!†
Methyl B12 with L-Methylfolate—Each serving contains a blend of bioavailable folate and vitamin B12 to support healthy methylation, homocysteine regulation, and energy production in a tasty, well-absorbed lozenge.†
Best SellerMethyl B12 with L-Methylfolate
4.9Rated 4.9 out of 5 stars762 ReviewsFrom $25Key Benefits and Actions† Active, methylated folate and B12 in a well-absorbed lozenge Potent methylation, homocysteine, and MTHFR support Suppo...
View full details -
Quench your body’s thirst for healthy hydration with the unique blend of ingredients found in the improved formula of Optimal Electrolyte!†
Optimal Electrolyte—Formulated with key ingredients, including sodium from real Himalayan pink salt and potassium, PeakATP®, niacin, and magnesium that easily mixes with water to support hydration for heart and muscle health.†
Best SellerImprovedOptimal Electrolyte
4.6Rated 4.6 out of 5 stars1,497 ReviewsFrom $38Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with PeakATP ®, HydroPrime ®, H...
View full details -
Start your day off right by giving your overall health and well-being top priority with Multivitamin One!†
Multivitamin One—A one-day multivitamin containing active forms of your essential daily nutrients in a well-absorbed capsule formulated without vitamin C, magnesium, calcium, or iron to allow customization.†
Best SellerMultivitamin One
4.8Rated 4.8 out of 5 stars373 ReviewsFrom $35Key Benefits and Actions† One-a-day multivitamin featuring bioavailable nutrients Methyl B12 and methylfolate support optimal methylation Powerf...
View full details -
A convenient way to experience our electrolyte blend for healthy muscle contraction and relaxation and heart rhythm and contraction support. Each stick contains one serving of Optimal Electrolyte to mix with a glass of water.†
Best SellerOptimal Electrolyte Sticks
4.7Rated 4.7 out of 5 stars26 ReviewsFrom $40Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with key ingredients for hydrat...
View full details -
Promote the healthy development of your baby’s brain, spinal cord, and immune system while supporting your pregnancy health with Prenatal Essentials!†
Prenatal Essentials—Contains only the essential nutrients you need in superior and bioavailable forms, including folinic acid, bioactive B12, and chelated minerals for targeted pregnancy support.†
Best SellerPrenatal Essentials
4.8Rated 4.8 out of 5 stars443 ReviewsFrom $35Key Benefits and Actions† 2-capsule serving size provides your prenatal vitamin essentials Bioavailable B12 and folate support healthy methylati...
View full details
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Support the healthy conversion of fat into energy with Acetyl-L-Carnitine.†
Acetyl-L-carnitine—A unique, bioavailable amino acid that supports healthy energy production, brain and nervous system function, and fat metabolism.†

Acetyl-L-Carnitine
Key Benefits and Actions† Supports conversion of fat into energy Supports healthy heart, brain, muscle, and sperm function Supports athletic per...
View full details