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Seeking Health we will be closed on May 27th in observance of the holiday. We will resume normal business hours on May 28th.
Seeking Health we will be closed on May 27th in observance of the holiday. We will resume normal business hours on May 28th.

L-5-MTHF - 25,500 mcg DFE (15,000 mcg/15mg)

$69.95
  • Supports healthy neurotransmitter formation
  • Supports healthy cognition and mood
  • Healthy genetic expression support
DISCONTINUED- This product has been discontinued. For the same active form of folate to support healthy methylation, try L-Methylfolate.

Who Needs L-5-MTHF - 25,500 mcg DFE (15,000 mcg/15mg)

Methylation controls multiple biochemical pathways in your body.

Your genetics, heart health, hormones, sleep, stress, mood, and detoxification depend on healthy methylation.

Where does your body get the methyl groups needed to carry out methylation? Primarily from folates that come from food and intestinal microbes. Food folates must be first converted into an active form before your body can use them.

Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).

Over 50 percent of the population is thought to have a genetic mutation in their MTHFR gene. Thus, they may not be achieving adequate methylfolate levels from food alone.

Because L-5-MTHF bypasses the MTHFR enzyme, it can provide methylation support for those with MTHFR polymorphisms.

Folate (as bioavailable L-5-MTHF) is:

  • Easily absorbed and used by cells
  • The predominant form of folate in circulation
  • The only form of folate that can cross the blood-brain barrier
  • Essential for methylation, DNA expression, homocysteine metabolism, and nervous system function

Seeking Health’s L-5-MTHF contains 25,500 mcg DFE of methylfolate in the bioavailable form of L-5-methyltetrahydrofolate (L-5-MTHF).

The bioactive form of L-methylfolate (L-5-MTHF) is well-utilized in the methylation cycle. It is often the preferred form for those with methylation, homocysteine, or MTHFR gene mutation concerns.

Mutations in your MTHFR gene can lead to reduced L-methylfolate production and a less functional methylation cycle. Challenges in the methylation cycle are associated with an increased risk for cardiovascular and mood issues, birth defects, and infertility concerns.

Mutations in this gene can also slow your body’s ability to convert folate into its active forms. Thus, a large majority of people may benefit from consuming an L-methylfolate dietary supplement.

The most direct way to support methylation and MTHFR genetic mutations is with L-methylfolate (L-5-MTHF).

Scientific research has demonstrated that higher strengths of L-5-MTHF may also support healthy neurotransmitter formation. A key cofactor is needed for both serotonin and dopamine metabolism. It is called BH4 or tetrahydrobiopterin. It appears that L-5-MTHF may help to both make more BH4 and also regenerate BH4 that has been previously used to make neurotransmitters. By doing so, L-5-MTHF plays an important role in assuring normal neurotransmitter formation takes place.

Supplementing with bioavailable L-5-MTHF supports:

  • Healthy methylation
  • Positive mood
  • Healthy homocysteine levels
  • Nervous system function and development
  • Prevention of neural tube defects during pregnancy
  • Healthy energy production
  • Normal cognitive, memory, and brain function

Our 25,500 mcg DFE capsule was designed for healthcare practitioners to recommend to their clients who they have identified as requiring extra support for methylation or neurotransmitter metabolism. This higher dose of folate is reserved for healthcare practitioners or clients who have been guided by their healthcare practitioners to address their increased needs. If you or your practitioner are concerned with getting too many methyl groups when taking a higher dose of L-5-MTHF, chemistry shows that the ingestion of higher levels of both glycine (an amino acid found in collagen) and niacin may support normal levels of methylation reactions.

Get ready for your methylation cycle to fire on all cylinders with Seeking Health’s L-5-MTHF!

Customer Review

Key Ingredients In L-5-MTHF - 25,500 mcg DFE (15,000 mcg/15mg)

  • L-5-MTHF: A superior form of L-methylfolate that readily donates its methyl groups. It aids conversion of the amino acid homocysteine into methionine and supports your entire methylation cycle.

Why L-5-MTHF - 25,500 mcg DFE (15,000 mcg/15mg) Works

Folate plays critical roles in methylation. By donating its methyl groups, folate regulates DNA expression and much more. Without sufficient bioavailable folate, your cells cannot effectively express your genes.

The MTHFR gene converts food folates into methyl folates. However, MTHFR variations and environmental or lifestyle stress can slow this gene down. If the MTHFR gene is slowed, MTHFR enzyme function is also slowed. The result can be a debilitating folate deficiency.

The artificial version of folate, folic acid, is often prescribed to folate-deficient individuals. Supplementation with L-5-MTHF may be more effective than folic acid supplementation at increasing blood folate levels.

Folic acid is never included in any of our Seeking Health dietary supplements. This artificial version of folate is not well-utilized by the body and can produce adverse effects. Folic acid must go through several enzymatic steps before it is converted into usable methylfolate. Its inefficient chemical structure may even slow down your SLC191A, DHFR, and MTHFR genes to the point of folate deficiency! Folic acid can also block usable folate from entering your cells, further contributing to folate deficiency.

By supplementing with the natural form of folate as L-5-MTHF, you bypass the MTHFR enzyme. The methylated form, L-5-methylfolate (L-5-MTHF), requires no additional metabolic steps to be used by the body. This is why it is often the preferred choice for those with folate absorption or metabolic defects.

L-5-MTHF also supports the production of important mood neurotransmitters. These include dopamine, serotonin, melatonin, epinephrine, and norepinephrine. Early on in both the serotonin and dopamine pathways, BH4 (tetrahydrobiopterin) is used as an essential cofactor. Research has indicated that higher strengths of L-5-MTHF can act both as a precursor for BH4 and also as an antioxidant that can regenerate BH4. By doing this, 5-MTHF supports the production of serotonin and its downstream metabolite serotonin as well as dopamine and its downstream metabolites epinephrine and norepinephrine. This is how supplementation with L-5-MTHF can help to support a healthy mood, focus, and sleep.

Seeking Heath’s L-5-MTHF provides a pure, non-racemic form of L-methylfolate. Each easy-to-take capsule offers a potent dose of 25,500 mcg DFE of folate as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt. This superior form supports healthy methylation, mood, and more.

Because folate needs B12 to support proper methylation, be sure to pair L-5-MTHF with a bioactive form of B12, such as Active B12 1000.

Now you can go about your day with confidence, knowing your methylation cycle is firing on all cylinders with L-5-MTHF!

L-5-MTHF - 25,500 mcg DFE (15,000 mcg/15mg)
Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60

AMT %DV
Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt) 25,500 mcg DFE (15,000 mcg) 6,375%
% DV (Daily Value) based on standard 2,000 calorie daily intake
**Daily Value not established

Other Ingredients: L-glycine, vegetarian capsule (hypromellose and water).

    NOT Suitable for Vegetarians or Vegans
  • How To Store: Keep closed in a cool, dry place out of reach by children.

How to Use L-5-MTHF - 25,500 mcg DFE (15,000 mcg/15mg)

Suggested Use

Take 1 capsule daily, or use as directed by your healthcare provider. Do not take within 5 hours of bedtime as it may interfere with sleep.

Warnings

Children and pregnant or lactating women should consult their healthcare professional for medical advice prior to use. Do not use if tamper seal is damaged. Consult a healthcare professional prior to use if you are taking any medications or undergoing treatment for any medical condition.

FAQs for L-5-MTHF - 25,500 mcg DFE (15,000 mcg/15mg)

What is the purpose of each ingredient in L-5-MTHF?

Ingredients Purpose
Folate (Quatrefolic® 6S)-5-methyltetrahydrofolate, glucosamine salt) Supports a healthy nervous system, methylation, homocysteine recycling, and prenatal regimen along with a healthy diet and lifestyle

How do I know if taking methylfolate (L-5-MTHF) works? How do I improve its utilization?

L-methylfolate (L-5-MTHF) is a superior form of folate that is well-utilized in the body. This is because 80 percent of the human body's folate is in this form.

L-5-MTHF is the form of folate that is used for methylation. Methylation is simply when one compound donates a methyl group to another compound. By having a methyl group attached, the compound's function changes.

At higher strengths, L-5-MTHF has also been shown to support healthy neurotransmitter metabolism by supporting the BH4 (tetrahydrobiopterin) cofactor used in both the serotonin and dopamine pathways.

You know when L-methylfolate works because of how you feel. It's typically very fast to notice if it's working or not.

According to Dr. Ben Lynch, supplementing with L-methylfolate can support healthy:

  • Mental clarity
  • Attention and focus
  • Energy production
  • Vision
  • Memory and recall
  • Circulation, especially in the hands and feet
  • Normal blood pressure
  • Normal homocysteine levels

In order for L-methylfolate to work, it requires vitamin B12. Reduced oxidative stress is also needed for L-methylfolate to function.

L-methylfolate needs the following to support methylation:

  • Vitamin B12
  • Zinc
  • Glutathione
  • Reduced oxidative stress
  • Functional MTR enzymes

Talk to your qualified healthcare practitioner before starting methylfolate supplementation. A trained health professional will be able to determine the appropriate dosing and whether methylfolate is right for you.

Which folate is right for me?

Click here to view our Folate Supplement Comparison Chart.

Read this blog: The different forms of folate: which one is right for you?

This blog article explains folic acid side effects.

If you have a question that's not addressed
here, see all frequently asked questions.

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What our customers say

Real reviews from real customers.

5.0
Rated 5.0 out of 5 stars
Based on 1 review
Total 5 star reviews: 1 Total 4 star reviews: 0 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 0
100%would recommend this product
1 review
  • BR
    Bianca R.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    11 months ago
    A must have!

    Helps my body function easier and with strength, combined with my other supplements.

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