Dirty Genes® - COMT Slow Support
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
Slow COMT activity may mean that you don’t have enough SAMe or too much homocysteine. Nutrients that support a balanced COMT gene include vitamin B12, other B vitamins, folate, and magnesium. Your MTHFR gene works closely with COMT, so you also need nutrients for methylation, like betaine and SAMe.
To support your slow COMT gene, you need supplementation that promotes the optimal way your gene should function. Hydrox-Adeno B12 and Folinic Acid provide bioavailable sources of vitamin B12 and folate in methyl-free versions, which might be easier to tolerate if you have a sensitive brain.
Explore other supportive nutrients for your COMT gene below, like Optimal Magnesium , Adrenal Support, or Optimal Sleep.
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Be kind to your gut while supporting its health with the low-histamine formula of ProBiota™ HistaminX™!†
ProBiota™ HistaminX™—A unique probiotic supplement designed specifically for those sensitive to histamine that contains histamine-friendly probiotics in an acid-resistant capsule.†
Best SellerProBiota™ HistaminX™
SHOP NOW $404.8Rated 4.8 out of 5 stars1,367 ReviewsFrom $40Key Benefits and Actions† Histamine-friendly probiotic formulated without strains known to produce high levels of histamine Supports microbiome ...
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Get the nutrients you need to support a healthy seasonal histamine response with Histamine Nutrients!†
Histamine Nutrients—Provides the nutrients needed to support healthy histamine breakdown, including DAOgest®, zinc, riboflavin, copper, and SAMe, to experience healthy histamine levels.†
Best SellerNew NameHistamine Nutrients
SHOP NOW $654.8Rated 4.8 out of 5 stars325 ReviewsFrom $65Key Benefits and Actions† Supports a healthy seasonal histamine response, outdoors and indoors Provides nutrients needed to support healthy hist...
View full detailsOriginal price $65 - Original price $390Original price $65 - Original price $390Original price $195$195$65.00 - $331.50(Save 67%)$65.00 - $331.50Original price $65.00 - Original price $390.00Original price $65.00 - Original price $390.00Original price $195.00$65.00 - $331.50$65.00 - $331.50Current price $65$65.00 - $331.50Current price $65 -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
SHOP NOW $204.8Rated 4.8 out of 5 stars205 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full detailsOriginal price $20 - Original price $120Original price $20 - Original price $120Original price $60$60$20.00 - $102.00(Save 67%)$20.00 - $102.00Original price $20.00 - Original price $120.00Original price $20.00 - Original price $120.00Original price $60.00$20.00 - $102.00$20.00 - $102.00Current price $20$20.00 - $102.00Current price $20 -
Help sustain healthy magnesium levels to support healthy sleep and feelings of relaxation and calm with Magnesium Plus†
Magnesium Plus—Provides two bioavailable forms of magnesium (malate and glycinate) plus the active form of vitamin B6 to enhance absorption in support of natural energy, relaxation, and GI comfort.†
Magnesium Plus
SHOP NOW $284.9Rated 4.9 out of 5 stars200 ReviewsFrom $28Key Benefits and Actions† Magnesium plus vitamin B6 for enhanced absorption and utilization Well-absorbed malate and glycinate forms of magnesiu...
View full detailsOriginal price $28 - Original price $168Original price $28 - Original price $168Original price $84$84$28.00 - $142.80(Save 67%)$28.00 - $142.80Original price $28.00 - Original price $168.00Original price $28.00 - Original price $168.00Original price $84.00$28.00 - $142.80$28.00 - $142.80Current price $28$28.00 - $142.80Current price $28 -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Magnesium Malate Powder
SHOP NOW $224.7Rated 4.7 out of 5 stars189 ReviewsFrom $22Key Benefits and Actions† Potent, powdered magnesium supplement Well-absorbed dimalate form of magnesium Supports healthy energy, muscles, nerve...
View full detailsOriginal price $22 - Original price $132Original price $22 - Original price $132Original price $66$66$22.00 - $112.20(Save 67%)$22.00 - $112.20Original price $22.00 - Original price $132.00Original price $22.00 - Original price $132.00Original price $66.00$22.00 - $112.20$22.00 - $112.20Current price $22$22.00 - $112.20Current price $22
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Be kind to your gut while supporting its health with the low-histamine formula of ProBiota™ HistaminX™!†
ProBiota™ HistaminX™—A unique probiotic supplement designed specifically for those sensitive to histamine that contains histamine-friendly probiotics in an acid-resistant capsule.†
Best SellerProBiota™ HistaminX™
SHOP NOW $404.8Rated 4.8 out of 5 stars1,367 ReviewsFrom $40Key Benefits and Actions† Histamine-friendly probiotic formulated without strains known to produce high levels of histamine Supports microbiome ...
View full detailsOriginal price $40 - Original price $240Original price $40 - Original price $240Original price $120$120$40.00 - $204.00(Save 67%)$40.00 - $204.00Original price $40.00 - Original price $240.00Original price $40.00 - Original price $240.00Original price $120.00$40.00 - $204.00$40.00 - $204.00Current price $40$40.00 - $204.00Current price $40 -
Get the nutrients you need to support a healthy seasonal histamine response with Histamine Nutrients!†
Histamine Nutrients—Provides the nutrients needed to support healthy histamine breakdown, including DAOgest®, zinc, riboflavin, copper, and SAMe, to experience healthy histamine levels.†
Best SellerNew NameHistamine Nutrients
SHOP NOW $654.8Rated 4.8 out of 5 stars325 ReviewsFrom $65Key Benefits and Actions† Supports a healthy seasonal histamine response, outdoors and indoors Provides nutrients needed to support healthy hist...
View full detailsOriginal price $65 - Original price $390Original price $65 - Original price $390Original price $195$195$65.00 - $331.50(Save 67%)$65.00 - $331.50Original price $65.00 - Original price $390.00Original price $65.00 - Original price $390.00Original price $195.00$65.00 - $331.50$65.00 - $331.50Current price $65$65.00 - $331.50Current price $65 -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
SHOP NOW $204.8Rated 4.8 out of 5 stars205 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full detailsOriginal price $20 - Original price $120Original price $20 - Original price $120Original price $60$60$20.00 - $102.00(Save 67%)$20.00 - $102.00Original price $20.00 - Original price $120.00Original price $20.00 - Original price $120.00Original price $60.00$20.00 - $102.00$20.00 - $102.00Current price $20$20.00 - $102.00Current price $20 -
Help sustain healthy magnesium levels to support healthy sleep and feelings of relaxation and calm with Magnesium Plus†
Magnesium Plus—Provides two bioavailable forms of magnesium (malate and glycinate) plus the active form of vitamin B6 to enhance absorption in support of natural energy, relaxation, and GI comfort.†
Magnesium Plus
SHOP NOW $284.9Rated 4.9 out of 5 stars200 ReviewsFrom $28Key Benefits and Actions† Magnesium plus vitamin B6 for enhanced absorption and utilization Well-absorbed malate and glycinate forms of magnesiu...
View full detailsOriginal price $28 - Original price $168Original price $28 - Original price $168Original price $84$84$28.00 - $142.80(Save 67%)$28.00 - $142.80Original price $28.00 - Original price $168.00Original price $28.00 - Original price $168.00Original price $84.00$28.00 - $142.80$28.00 - $142.80Current price $28$28.00 - $142.80Current price $28 -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Magnesium Malate Powder
SHOP NOW $224.7Rated 4.7 out of 5 stars189 ReviewsFrom $22Key Benefits and Actions† Potent, powdered magnesium supplement Well-absorbed dimalate form of magnesium Supports healthy energy, muscles, nerve...
View full detailsOriginal price $22 - Original price $132Original price $22 - Original price $132Original price $66$66$22.00 - $112.20(Save 67%)$22.00 - $112.20Original price $22.00 - Original price $132.00Original price $22.00 - Original price $132.00Original price $66.00$22.00 - $112.20$22.00 - $112.20Current price $22$22.00 - $112.20Current price $22
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Be kind to your gut while supporting its health with the low-histamine formula of ProBiota™ HistaminX™!†
ProBiota™ HistaminX™—A unique probiotic supplement designed specifically for those sensitive to histamine that contains histamine-friendly probiotics in an acid-resistant capsule.†
Best SellerProBiota™ HistaminX™
SHOP NOW $404.8Rated 4.8 out of 5 stars1,367 ReviewsFrom $40Key Benefits and Actions† Histamine-friendly probiotic formulated without strains known to produce high levels of histamine Supports microbiome ...
View full detailsOriginal price $40 - Original price $240Original price $40 - Original price $240Original price $120$120$40.00 - $204.00(Save 67%)$40.00 - $204.00Original price $40.00 - Original price $240.00Original price $40.00 - Original price $240.00Original price $120.00$40.00 - $204.00$40.00 - $204.00Current price $40$40.00 - $204.00Current price $40 -
Get the nutrients you need to support a healthy seasonal histamine response with Histamine Nutrients!†
Histamine Nutrients—Provides the nutrients needed to support healthy histamine breakdown, including DAOgest®, zinc, riboflavin, copper, and SAMe, to experience healthy histamine levels.†
Best SellerNew NameHistamine Nutrients
SHOP NOW $654.8Rated 4.8 out of 5 stars325 ReviewsFrom $65Key Benefits and Actions† Supports a healthy seasonal histamine response, outdoors and indoors Provides nutrients needed to support healthy hist...
View full detailsOriginal price $65 - Original price $390Original price $65 - Original price $390Original price $195$195$65.00 - $331.50(Save 67%)$65.00 - $331.50Original price $65.00 - Original price $390.00Original price $65.00 - Original price $390.00Original price $195.00$65.00 - $331.50$65.00 - $331.50Current price $65$65.00 - $331.50Current price $65 -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
SHOP NOW $204.8Rated 4.8 out of 5 stars205 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full detailsOriginal price $20 - Original price $120Original price $20 - Original price $120Original price $60$60$20.00 - $102.00(Save 67%)$20.00 - $102.00Original price $20.00 - Original price $120.00Original price $20.00 - Original price $120.00Original price $60.00$20.00 - $102.00$20.00 - $102.00Current price $20$20.00 - $102.00Current price $20 -
Help sustain healthy magnesium levels to support healthy sleep and feelings of relaxation and calm with Magnesium Plus†
Magnesium Plus—Provides two bioavailable forms of magnesium (malate and glycinate) plus the active form of vitamin B6 to enhance absorption in support of natural energy, relaxation, and GI comfort.†
Magnesium Plus
SHOP NOW $284.9Rated 4.9 out of 5 stars200 ReviewsFrom $28Key Benefits and Actions† Magnesium plus vitamin B6 for enhanced absorption and utilization Well-absorbed malate and glycinate forms of magnesiu...
View full detailsOriginal price $28 - Original price $168Original price $28 - Original price $168Original price $84$84$28.00 - $142.80(Save 67%)$28.00 - $142.80Original price $28.00 - Original price $168.00Original price $28.00 - Original price $168.00Original price $84.00$28.00 - $142.80$28.00 - $142.80Current price $28$28.00 - $142.80Current price $28 -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Magnesium Malate Powder
SHOP NOW $224.7Rated 4.7 out of 5 stars189 ReviewsFrom $22Key Benefits and Actions† Potent, powdered magnesium supplement Well-absorbed dimalate form of magnesium Supports healthy energy, muscles, nerve...
View full detailsOriginal price $22 - Original price $132Original price $22 - Original price $132Original price $66$66$22.00 - $112.20(Save 67%)$22.00 - $112.20Original price $22.00 - Original price $132.00Original price $22.00 - Original price $132.00Original price $66.00$22.00 - $112.20$22.00 - $112.20Current price $22$22.00 - $112.20Current price $22
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