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Seeking Health we will be closed on May 27th in observance of the holiday. We will resume normal business hours on May 28th.
Seeking Health we will be closed on May 27th in observance of the holiday. We will resume normal business hours on May 28th.



DIM Supplement

  • Supports healthy liver metabolism of estrogens
  • Supports detoxification and elimination
  • Supports healthy inflammatory responses and cellular defenses

Who Needs DIM + I3C

Are you exposed to plastics, conventional meat and dairy, or conventional household products on a regular basis?

All of these have one thing in common - they contain chemicals that may harm human cells and promote free radicals in the body. In the presence of free radicals, estrogenic activity and estrogen metabolism are influenced. Toxin exposure typically affects the endocrine system by increasing estrogen production or estrogen activity. This is called estrogen dominance. The effects of estrogen in high quantities in the body should not be overlooked.

Do you have estrogen dominance? Are you concerned about supporting a healthy hormone balance?

DIM+I3C is a targeted formula that supports healthy estrogen metabolism and a healthy oxidative stress responses associated with xenoestrogen exposure.

DIM (diindolylmethane) is a byproduct of I3C (indole-3-carbinol), a compound found in broccoli, cabbage and cruciferous vegetables. Both DIM and I3C are dietary indoles, which support normal processing of estrogen metabolites.

A healthy balance between steroid hormones is vital. Estrogen, progesterone, testosterone, and other adrenal hormones and sex hormones (androgens) are incredibly important for reproductive health, sexual health, and overall vitality. However, when estrogen levels get too high from toxin exposure, liver overload, or the use of prescriptions, other important hormones can drop to dangerously low levels. This can put adrenal health, emotional health, and female menses cycles in danger.

PQQ (from Pyrroloquinoline Quinone Disodium Salt) is added to support healthy oxidation of free radicals due to xenoestrogen (chemical estrogen mimickers) exposure and higher estrogen overall. Oxidative stress due to free radicals has a wide impact on all epigenetic controls. Keeping these balanced helps to support the healthy expression of hormone balancing and detoxification genes. Hormones are such a large factor in mental well-being, as they play a part in neurotransmitter balance and feelings of joy.

DIM + I3C can specifically support healthy estrogen metabolism in individuals with high estrogen exposure. The incidence of higher estrogen may be more prevalent in the following individuals:

  • Those exposed to toxins and free radicals
  • Those with a change in menopausal status
  • Those on hormonal therapy
  • Premenopausal and postmenopausal women
  • Those taking contraceptives
  • Those at risk for uncontrolled cell growth of the breast tissue
  • Those with abnormal ovarian tissue growth
  • Those struggling with weight issues

Seeking Health’s DIM + I3C is an important product to have on hand to support healthy estrogen metabolism. When your hormones are balanced and supported, you will feel calm and have healthy energy levels. Support that balance today!

Customer Review


Excellent product for balancing estrogen metabolism. Noticeable results with continued use. Highly recommend! ~Amy J.

Key Ingredients In DIM + I3C

  • I3C (indole-3-carbinol): Supports healthy estrogen balance
  • DIM (diindolylmethane): A byproduct of indole-3-carbinol, helps to support healthy estrogen balance
  • PQQ (from Pyrroloquinoline Quinone Disodium Salt): Supports a healthy response to oxidative stress associated with xenoestrogen exposure

Why DIM + I3C Works

The consumption of broccoli and other cruciferous vegetables has long been associated with supporting normal detoxification processes. One chemical that has been isolated from these vegetables is Indole-3-carbinol or I3C. In the presence of acid in the stomach and some enzymes, this compound can metabolize into another compound known as diindolylmethane or DIM.

Both I3C and DIM have been shown to have the ability to change gene transcription. In other words, they can change how your cells make certain proteins. Research has shown that taking I3C and DIM may increase the expression of certain enzymes. These include cytochrome p450 (CYP450) phase 1 detoxification enzymes as well as phase II conjugation enzymes.

One of the most important “detoxification” pathways in the human body involves hormones and hormone-like chemicals. Few people realize that levels of estrogen need to be within specific limits. The role of estrogen in the body is important. Endogenous estrogen is vital for the growth of certain tissues. In the presence of too much estrogen, however, uncontrolled tissue cell growth can occur. To balance these risks, the body keeps tight control over how much estrogen is allowed to circulate. The body also regulates what type of estrogens are produced. It accomplishes this by carefully metabolizing or “detoxifying” excess estrogen.

It is well known that food components change gene transcription. In other words, when you eat certain foods, certain genes are either induced or “turned on” while other genes are inhibited or “turned off.” The genes that are turned on in the presence of I3C and DIM, are key players in the healthy metabolism of estrogen. When I3C and DIM are around, certain cytochrome P450 enzymes will be induced. These place a hydroxyl group on a specific carbon of the estrogen. When this hydroxyl group is on the second carbon, the type of estrogen metabolite that is made is less harmful to the body. When other enzymes are used instead, it is possible for the body to make more harmful metabolites by placing the hydroxyl group on the 4th or 16th carbon of estrogen.

These estrogen byproducts may damage cells. In the presence of damaged cells, the immune system may respond by increasing inflammation and oxidative stress. In essence, I3C and DIM helps ensure a healthy balance of normal estrogen metabolites are produced.

Estrogen metabolism is not the only thing that is supported with the intake of I3C and DIM from foods and supplements. This very same gene inducing behavior supports the metabolism of a multitude of estrogen-like chemicals in the environment as well. Whether it is plastics, fragrances, or fuel byproducts, when estrogen-shaped chemicals are processed in the liver, I3C and DIM will support their healthy normal metabolism.

DIM + I3C is designed to support your body’s natural processes to metabolize and detoxify. Try Seeking Health’s DIM + I3C today so you can get started supporting healthy hormone and toxin metabolism.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60

I3C (indole-3-carbinol) 200 mg **
DIM (diindolymethane) 200 mg **
LifePQQTM Pyrroloquinoline Quinone Disodium Salt 4 mg **
**Daily Value (DV) not established.

Other Ingredients: Vegetarian capsule (hydroxypropyl methylcellulose and water) and L-leucine.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Capsules
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use DIM + I3C

Suggested Use

As needed, take 1 capsule any time, day or night, with or without food. Use as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Suitable for


Delivery Method


How to Store

Keep closed in a cool, dry place out of reach by children.

FAQs for DIM + I3C

What is the purpose of each ingredient in DIM+I3C?

Ingredients Purpose
I3C (indole-3-carbinol) Support for the healthy processing of estrogen metabolites and hormone balance
DIM (diindolylmethane) Support for the healthy processing of estrogen metabolites and hormone balance
PQQ (from Pyrroloquinoline Quinone Disodium Salt) Support for the body’s natural cellular defenses

Who is DIM + I3C intended for?

DIM + I3C is intended for those seeking to support the body’s healthy estrogen influence and metabolism. It also contains added PQQ, which can support a healthy oxidative response for healthy hormone levels and detoxification.

How to use DIM + I3C?

Take 1 capsule, 1 to 2 times daily or as directed by your healthcare professional.

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What our customers say

Real reviews from real customers.

Rated 4.8 out of 5 stars
Based on 130 reviews
Total 5 star reviews: 115 Total 4 star reviews: 9 Total 3 star reviews: 3 Total 2 star reviews: 2 Total 1 star reviews: 1
96%would recommend this product
130 reviews
  • SG
    Susan G.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    4 weeks ago

    Just what my physician/NP ordered. Delivery was excellent

  • SK
    Stacie K.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    Hormone metabolizer

    I feel the Dim works great. This product was recommended by my doctor and I have been happy with its use.

  • JS Profile picture for Jenny S.
    Jenny S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    4 months ago
    Second time around and no problems!

    I submitted a previous review below about starting SLOW due to itching. This time around I'm taking it with CDG and after taking both at the same time at bedtime for a week, I have yet to experience any itching or other detox symptoms so I would highly suggest taking the DIM with the CDG together for added efficacy. I'm still doing castor oil on my liver periodically to keep the detox pathways supported.

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