The consumption of broccoli and other cruciferous vegetables has long been associated with supporting normal detoxification processes. One chemical that has been isolated from these vegetables is Indole-3-carbinol or I3C. In the presence of acid in the stomach and some enzymes, this compound can metabolize into another compound known as diindolylmethane or DIM.^†

Both I3C and DIM have been shown to have the ability to change gene transcription. In other words, they can change how your cells make certain proteins. Research has shown that taking I3C and DIM may increase the expression of certain enzymes. These include cytochrome p450 (CYP450) phase 1 detoxification enzymes as well as phase II conjugation enzymes.^†

One of the most important “detoxification” pathways in the human body involves hormones and hormone-like chemicals. Few people realize that levels of estrogen need to be within specific limits. The role of estrogen in the body is important. Endogenous estrogen is vital for the growth of certain tissues. In the presence of too much estrogen, however, uncontrolled tissue cell growth can occur. To balance these risks, the body keeps tight control over how much estrogen is allowed to circulate. The body also regulates what type of estrogens are produced. It accomplishes this by carefully metabolizing or “detoxifying” excess estrogen.

It is well known that food components change gene transcription. In other words, when you eat certain foods, certain genes are either induced or “turned on” while other genes are inhibited or “turned off.” The genes that are turned on in the presence of I3C and DIM, are key players in the healthy metabolism of estrogen. When I3C and DIM are around, certain cytochrome P450 enzymes will be induced. These place a hydroxyl group on a specific carbon of the estrogen. When this hydroxyl group is on the second carbon, the type of estrogen metabolite that is made is less harmful to the body. When other enzymes are used instead, it is possible for the body to make more harmful metabolites by placing the hydroxyl group on the 4th or 16th carbon of estrogen. ^†

These estrogen byproducts may damage cells. In the presence of damaged cells, the immune system may respond by increasing inflammation and oxidative stress. In essence, I3C and DIM helps ensure a healthy balance of normal estrogen metabolites are produced.^†

Estrogen metabolism is not the only thing that is supported with the intake of I3C and DIM from foods and supplements. This very same gene inducing behavior supports the metabolism of a multitude of estrogen-like chemicals in the environment as well. Whether it is plastics, fragrances, or fuel byproducts, when estrogen-shaped chemicals are processed in the liver, I3C and DIM will support their healthy normal metabolism. ^†

DIM + I3C is designed to support your body’s natural processes to metabolize and detoxify. Try Seeking Health’s DIM + I3C today so you can get started supporting healthy hormone and toxin metabolism.^†