Dirty Genes® - MTHFR Supplements
If you have an MTHFR gene SNP, you need supplementation that is bioavailable and doesn’t slow down your methylation processes. MTHFR (short for methylenetetrahydrofolate reductase) produces an enzyme that helps regulate how well your DNA methylation cycle works. Polymorphisms mean that MTHFR less efficiently converts folic acid (vitamin B9) and vitamin B12 to active forms.
If you have an MTHFR gene SNP, you need supplementation that is bioavailable and doesn’t slow down your methylation processes. MTHFR (short for methylenetetrahydrofolate reductase) produces an enzyme that helps regulate how well your DNA methylation cycle works. Polymorphisms mean that MTHFR less efficiently converts folic acid (vitamin B9) and vitamin B12 to active forms.
An impaired MTHFR gene can also lead to high homocysteine levels, detoxification challenges, and an increased risk for other problems.
For optimal health, you need bioavailable, methylated nutrients like methylcobalamin (methyl-B12), L-5-MTHF (methylfolate), SAMe, creatine, phosphatidylcholine, and more.
These work to support your body’s methylation processes by reducing the effort needed to activate them.
Your MTHFR gene mutation doesn’t have to confuse you. Get started with MTHFR supplements today. Try Seeking Health’s popular Optimal Multivitamin for comprehensive nutrient support. Or get HomocysteX Plus, which helps to support normal homocysteine conversion. B Complex Plus is a great way to support a healthy MTHFR enzyme.
Not sure where to start with a multivitamin? Use this chart to compare products.

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Support healthy liver metabolism of estrogens, detoxification, and elimination with DIM+13C.†
DIM+I3C—A targeted formula that supports healthy estrogen metabolism and a healthy oxidative stress response associated with xenoestrogen exposure.†
DIM + I3C
4.8Rated 4.8 out of 5 stars145 ReviewsFrom $43Key Benefits and Actions† Supports healthy liver metabolism of estrogens Supports detoxification and elimination Supports healthy inflammatory r...
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Start your kids’ day off right with the bioavailable nutrients they need to keep going with Kids Multivitamin Chewable MF!†
Kids Multivitamin Chewable MF—A comprehensive multivitamin and multimineral with methyl-sensitive kids in mind in a great-tasting, kid-approved, and sugar-free chewable.†
SaleBOGOKids Multivitamin Chewable MF
4.6Rated 4.6 out of 5 stars29 ReviewsFrom $30Great-tasting, kid-approved and sugar free Supports methyl-sensitive kids from 1 year old and up Comprehensive kid’s multivitamin and multimin...
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Promote the healthy development of your baby’s brain, spinal cord, and immune system while supporting your pregnancy health with Prenatal Essentials!†
Prenatal Essentials—Contains only the essential nutrients you need in superior and bioavailable forms, including folinic acid, bioactive B12, and chelated minerals for targeted pregnancy support.†
Best SellerPrenatal Essentials
4.8Rated 4.8 out of 5 stars436 ReviewsFrom $35Key Benefits and Actions† 2-capsule serving size provides your prenatal vitamin essentials Bioavailable B12 and folate support healthy methylati...
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Help support your hard-working liver to aid in healthy detoxification, glutathione production, and cell function with Liver Nutrients!†
Liver Nutrients—An all-in-one liver-support dietary supplement with a synergistic blend of nutrients and herbs supports the healthy metabolism of toxins and hormones in the liver and promotes normal glutathione production and liver cell regeneration.†
Best SellerLiver Nutrients
4.9Rated 4.9 out of 5 stars337 ReviewsFrom $24Key Benefits and Actions† Phase 2 liver detoxification support Glutathione production support Liver cell function support Who Needs Liver Nutr...
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Start the day off right and support healthy cognition, focus, clarity, and learning on the job or in school with Optimal Focus!†
Optimal Focus—A stimulant-free supplement that supports healthy learning, memory, attention, and concentration no matter what stage of life.†
SaleBOGOOptimal Focus
4.6Rated 4.6 out of 5 stars115 ReviewsFrom $70Key Benefits and Actions† Supports healthy memory Cognitive function support such as clarity, focus, and learning Stimulant-Free support for nor...
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Give your body the methyl-free support it needs while still getting your daily dose of vitamins with Multivitamin One MF.†
Multivitamin One MF—A one-a-day multivitamin containing many essential daily nutrients in methyl-free forms, delivered in a well-absorbed capsule without vitamin C, magnesium, calcium, or iron to allow customization.†
Multivitamin One MF
4.9Rated 4.9 out of 5 stars275 ReviewsFrom $35Key Benefits and Actions† One-a-day multivitamin featuring methyl-free B12 and folate Methyl-free support for those sensitive to methylated nutr...
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Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars179 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
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Get your daily dose of highly-concentrated omega-3s for cardiovascular and heart health support with Fish Oil.†
Fish Oil—Includes omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that support healthy joint function, normal body weight, normal inflammatory response, and healthy blood pressure.†
Fish Oil
5.0Rated 5.0 out of 5 stars126 ReviewsFrom $40Key Benefits and Actions† Burp-free, taste-free and easy to swallow 400 mg of DHA + 400 mg of EPA as triglycerides per softgel Wild caught...
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Promote sustainable energy by supporting methylation, homocysteine, and MTHFR with Methyl B12 with L-Methylfolate!†
Methyl B12 with L-Methylfolate—Each serving contains a blend of bioavailable folate and vitamin B12 to support healthy methylation, homocysteine regulation, and energy production in a tasty, well-absorbed lozenge.†
Best SellerMethyl B12 with L-Methylfolate
4.9Rated 4.9 out of 5 stars758 ReviewsFrom $25Key Benefits and Actions† Active, methylated folate and B12 in a well-absorbed lozenge Potent methylation, homocysteine, and MTHFR support Suppo...
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Support a healthy stress response, thyroid and adrenal function, and feelings of calm with Ashwagandha.†
Ashwagandha—A powerful adaptogen formula that is vegan-friendly with over 400 mg of ashwagandha root extract to support feelings of calm and stress resilience in each capsule.†
Ashwagandha
4.9Rated 4.9 out of 5 stars146 ReviewsFrom $25Key Benefits and Actions† High-quality ashwagandha root extract Powerful stress support for life’s everyday stressors Supports a healthy stress ...
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Target healthy immune system support and healthy inflammatory responses with HistaminX!†
HistaminX—Specially formulated for immune health and seasonal comfort, featuring herbal and plant-derived compounds that synergistically support healthy inflammatory responses.†
HistaminX
4.7Rated 4.7 out of 5 stars189 ReviewsFrom $45Key Benefits and Actions† Healthy immune system support Support for healthy lungs, nose, and airway Supports healthy inflammatory responses Who...
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Get all-in-one health support with the specially formulated blend of nutrients found in Optimal Man™!†
Optimal Man™—A complete multivitamin/multimineral containing supportive herbs with antioxidant properties to support healthy testosterone levels and men’s health and fertility.†
Best SellerOptimal Man™
4.8Rated 4.8 out of 5 stars125 ReviewsFrom $65Key Benefits and Actions† Supports men’s health and male fertility Supports healthy testosterone levels Supports healthy cognition, energy, and ...
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Keep your homocysteine levels in check with the unique formula found in Homocysteine Nutrients!†
Homocysteine Nutrients—Provides the 5 nutrients your body requires for optimal methylation, including folate, methylcobalamin, and adenosylcobalamin, to support normal homocysteine breakdown for heart health support.†
Best SellerHomocysteine Nutrients
4.9Rated 4.9 out of 5 stars259 ReviewsFrom $35Key Benefits and Actions† Supports healthy methylation and homocysteine levels Powerful heart health support Supports healthy cognition and brai...
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Start your kids’ day off right with great-tasting and sugar-free Kids Multivitamin Chewable!
Kids Multivitamin Chewable—A comprehensive kids’ multivitamin and multimineral that supports their growth, genes, and important pathways in a tasty, kid-approved chewable.†
ImprovedKids Multivitamin Chewable
4.6Rated 4.6 out of 5 stars49 ReviewsFrom $30Great-tasting, kid-approved and sugar-free Supports kids from 4 years old and up Comprehensive kid’s multivitamin and multimineral During your...
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Support normal hormone balance, a balanced mood, and healthy energy production with B Complex Plus.†
B Complex Plus—A potent vitamin B complex supplement that provides active forms of the 8 essential B vitamins plus choline for additional methylation support.†
Best SellerB Complex Plus
4.9Rated 4.9 out of 5 stars426 ReviewsFrom $30Key Benefits and Actions† Healthy energy production support Supports normal hormone balance and mood Supports healthy methylation and homocystei...
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Choose the natural way to support a healthy stress response, cortisol regulation, and feelings of calm with Stress Nutrients!†
Stress Nutrients—A vegan-friendly adrenal support supplement. Nutrients, plant extracts, and herbs synergistically support adrenal health and a normal stress response.†
Stress Nutrients
4.9Rated 4.9 out of 5 stars113 ReviewsFrom $38Key Benefits and Actions† Non-glandular adrenal support supplement Synergistic nutrients and herbs for healthy stress responses Supports healthy...
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Support healthy detoxification and immune system functioning with easy-to-swallow Glutathione Plus!†
Glutathione Plus—A unique formula with Emothion™ S-Acetyl-L-Glutathione and LifePQQ™ for lung, skin, eye, and immune system support, all in a small taste- and smell-free capsule!†
Best SellerGlutathione Plus
4.9Rated 4.9 out of 5 stars142 ReviewsFrom $65Key Benefits and Actions† Supports healthy lungs, skin, eyes and immune system Triple glutathione protection due to unique formulation Easy to s...
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Get the nutrients you need to support a healthy seasonal histamine response with Histamine Nutrients!†
Histamine Nutrients—Provides the nutrients needed to support healthy histamine breakdown, including DAOgest®, zinc, riboflavin, copper, and SAMe, to experience healthy histamine levels.†
Best SellerNew NameHistamine Nutrients - Formerly Histamine Block Plus
4.8Rated 4.8 out of 5 stars273 ReviewsFrom $65Key Benefits and Actions† Supports a healthy seasonal histamine response, outdoors and indoors Provides nutrients needed to support healthy hist...
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Support healthy aging, detoxification, immune system health, and physical activity with the antioxidative properties found in Liposomal Glutathione.†
Liposomal Glutathione—Contains 100 mg of reduced glutathione packaged in soy-free liposomes to enhance absorption and delivery in every serving.†
SaleBest SellerBOGOWhile Supplies LastLiposomal Glutathione
4.8Rated 4.8 out of 5 stars403 ReviewsFrom $50Key Benefits and Actions† Powerful, well-absorbed, liposomal glutathione Reduced form promotes superior antioxidant activity Supports healthy ...
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Be kind to your gut while supporting its health with the low-histamine formula of ProBiota™ HistaminX™!†
ProBiota™ HistaminX™—A unique probiotic supplement designed specifically for those sensitive to histamine that contains histamine-friendly probiotics in an acid-resistant capsule.†
Best SellerProBiota™ HistaminX™
4.8Rated 4.8 out of 5 stars1,287 ReviewsFrom $40Key Benefits and Actions† Histamine-friendly probiotic formulated without strains known to produce high levels of histamine Supports microbiome ...
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Quench your body’s thirst for healthy hydration with the unique blend of ingredients found in the improved formula of Optimal Electrolyte!†
Optimal Electrolyte—Formulated with key ingredients, including sodium from real Himalayan pink salt and potassium, PeakATP®, niacin, and magnesium that easily mixes with water to support hydration for heart and muscle health.†
Best SellerImprovedOptimal Electrolyte
4.6Rated 4.6 out of 5 stars1,479 ReviewsFrom $38Supports healthy muscle contraction and relaxation Supports healthy heart rhythm and contraction Hydration Blend with PeakATP ®, HydroPrime ®, H...
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Start your day off right by giving your overall health and well-being top priority with Multivitamin One!†
Multivitamin One—A one-day multivitamin containing active forms of your essential daily nutrients in a well-absorbed capsule formulated without vitamin C, magnesium, calcium, or iron to allow customization.†
Best SellerMultivitamin One
4.8Rated 4.8 out of 5 stars368 ReviewsFrom $35Key Benefits and Actions† One-a-day multivitamin featuring bioavailable nutrients Methyl B12 and methylfolate support optimal methylation Powerf...
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Support healthy methylation, MTHFR, and homocysteine levels with bioavailable L-Methylfolate!†
L-Methylfolate—A superior form of L-methylfolate that readily donates its methyl groups, aids the conversion of the amino acid homocysteine into methionine, and supports your entire methylation cycle.†
L-Methylfolate
4.7Rated 4.7 out of 5 stars95 ReviewsFrom $20Key Benefits and Actions† Powerful methylation, MTHFR, and homocysteine support Supports healthy cognition and mood Healthy genetic expression s...
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Support healthy energy production, oxidative stress, and aging responses with PQQ Lozenge!†
PQQ Lozenge—Contains 20 mg of Pyrroloquinoline Quinone Disodium Salt (PQQ), an antioxidant-like nutrient that supports healthy energy production and responses to oxidative stress.†
Best SellerPQQ Lozenge
4.7Rated 4.7 out of 5 stars298 ReviewsFrom $35Key Benefits and Actions† Healthy energy production support Healthy response to oxidative stress Supports healthy aging processes Who Needs PQQ...
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