Dirty Genes® - MTHFR Supplements
If you have an MTHFR gene SNP, you need supplementation that is bioavailable and doesn’t slow down your methylation processes. MTHFR (short for methylenetetrahydrofolate reductase) produces an enzyme that helps regulate how well your DNA methylation cycle works. Polymorphisms mean that MTHFR less efficiently converts folic acid (vitamin B9) and vitamin B12 to active forms.
If you have an MTHFR gene SNP, you need supplementation that is bioavailable and doesn’t slow down your methylation processes. MTHFR (short for methylenetetrahydrofolate reductase) produces an enzyme that helps regulate how well your DNA methylation cycle works. Polymorphisms mean that MTHFR less efficiently converts folic acid (vitamin B9) and vitamin B12 to active forms.
An impaired MTHFR gene can also lead to high homocysteine levels, detoxification challenges, and an increased risk for other problems.
For optimal health, you need bioavailable, methylated nutrients like methylcobalamin (methyl-B12), L-5-MTHF (methylfolate), SAMe, creatine, phosphatidylcholine, and more.
These work to support your body’s methylation processes by reducing the effort needed to activate them.
Your MTHFR gene mutation doesn’t have to confuse you. Get started with MTHFR supplements today. Try Seeking Health’s popular Optimal Multivitamin for comprehensive nutrient support. Or get HomocysteX Plus, which helps to support normal homocysteine conversion. B Complex Plus is a great way to support a healthy MTHFR enzyme.
Not sure where to start with a multivitamin? Use this chart to compare products.

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Start your kids’ day off right with the bioavailable nutrients they need to keep going with Kids Multivitamin Chewable MF!†
Kids Multivitamin Chewable MF—A comprehensive multivitamin and multimineral with methyl-sensitive kids in mind in a great-tasting, kid-approved, and sugar-free chewable.†
Kids Multivitamin Chewable MF
4.4Rated 4.4 out of 5 stars36 ReviewsFrom $30Great-tasting, kid-approved and sugar free Supports methyl-sensitive kids from 1 year old and up Comprehensive kid’s multivitamin and multimin...
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Give your body the methyl-free support it needs while still getting your daily dose of vitamins with Multivitamin One MF.†
Multivitamin One MF—A one-a-day multivitamin containing many essential daily nutrients in methyl-free forms, delivered in a well-absorbed capsule without vitamin C, magnesium, calcium, or iron to allow customization.†
Multivitamin One MF
4.9Rated 4.9 out of 5 stars281 ReviewsFrom $35Key Benefits and Actions† One-a-day multivitamin featuring methyl-free B12 and folate Methyl-free support for those sensitive to methylated nutr...
View full details -
Foster healthy energy production and mood with methyl-free B Complex MF.†
B Complex MF—A potent B vitamin complex containing the 8 essential B vitamins, featuring non-methylated B12 and folate in the forms of Hydroxo B12 and folinic acid.†
B Complex MF
4.6Rated 4.6 out of 5 stars111 ReviewsFrom $30Key Benefits and Actions† Methyl-free vitamin B complex Supports healthy energy production Supports a healthy mood Who Needs B Complex MF Have...
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Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars186 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full details -
Support a healthy lifestyle and balanced diet during pregnancy, especially if you’re methyl-sensitive with Prenatal Essentials MF.†
Prenatal Essentials MF—A concise yet powerful prenatal multivitamin. It supports methylation with bioavailable, methyl-free forms of key pregnancy nutrients.†
Prenatal Essentials MF
5.0Rated 5.0 out of 5 stars104 ReviewsFrom $35Key Benefits and Actions† 2-capsule serving size provides your essential daily prenatal nutrients in methyl-free forms Supports healthy immune, ...
View full details
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Start your kids’ day off right with the bioavailable nutrients they need to keep going with Kids Multivitamin Chewable MF!†
Kids Multivitamin Chewable MF—A comprehensive multivitamin and multimineral with methyl-sensitive kids in mind in a great-tasting, kid-approved, and sugar-free chewable.†
Kids Multivitamin Chewable MF
4.4Rated 4.4 out of 5 stars36 ReviewsFrom $30Great-tasting, kid-approved and sugar free Supports methyl-sensitive kids from 1 year old and up Comprehensive kid’s multivitamin and multimin...
View full details -
Give your body the methyl-free support it needs while still getting your daily dose of vitamins with Multivitamin One MF.†
Multivitamin One MF—A one-a-day multivitamin containing many essential daily nutrients in methyl-free forms, delivered in a well-absorbed capsule without vitamin C, magnesium, calcium, or iron to allow customization.†
Multivitamin One MF
4.9Rated 4.9 out of 5 stars281 ReviewsFrom $35Key Benefits and Actions† One-a-day multivitamin featuring methyl-free B12 and folate Methyl-free support for those sensitive to methylated nutr...
View full details -
Foster healthy energy production and mood with methyl-free B Complex MF.†
B Complex MF—A potent B vitamin complex containing the 8 essential B vitamins, featuring non-methylated B12 and folate in the forms of Hydroxo B12 and folinic acid.†
B Complex MF
4.6Rated 4.6 out of 5 stars111 ReviewsFrom $30Key Benefits and Actions† Methyl-free vitamin B complex Supports healthy energy production Supports a healthy mood Who Needs B Complex MF Have...
View full details -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars186 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full details -
Support a healthy lifestyle and balanced diet during pregnancy, especially if you’re methyl-sensitive with Prenatal Essentials MF.†
Prenatal Essentials MF—A concise yet powerful prenatal multivitamin. It supports methylation with bioavailable, methyl-free forms of key pregnancy nutrients.†
Prenatal Essentials MF
5.0Rated 5.0 out of 5 stars104 ReviewsFrom $35Key Benefits and Actions† 2-capsule serving size provides your essential daily prenatal nutrients in methyl-free forms Supports healthy immune, ...
View full details
-
Start your kids’ day off right with the bioavailable nutrients they need to keep going with Kids Multivitamin Chewable MF!†
Kids Multivitamin Chewable MF—A comprehensive multivitamin and multimineral with methyl-sensitive kids in mind in a great-tasting, kid-approved, and sugar-free chewable.†
Kids Multivitamin Chewable MF
4.4Rated 4.4 out of 5 stars36 ReviewsFrom $30Great-tasting, kid-approved and sugar free Supports methyl-sensitive kids from 1 year old and up Comprehensive kid’s multivitamin and multimin...
View full details -
Give your body the methyl-free support it needs while still getting your daily dose of vitamins with Multivitamin One MF.†
Multivitamin One MF—A one-a-day multivitamin containing many essential daily nutrients in methyl-free forms, delivered in a well-absorbed capsule without vitamin C, magnesium, calcium, or iron to allow customization.†
Multivitamin One MF
4.9Rated 4.9 out of 5 stars281 ReviewsFrom $35Key Benefits and Actions† One-a-day multivitamin featuring methyl-free B12 and folate Methyl-free support for those sensitive to methylated nutr...
View full details -
Foster healthy energy production and mood with methyl-free B Complex MF.†
B Complex MF—A potent B vitamin complex containing the 8 essential B vitamins, featuring non-methylated B12 and folate in the forms of Hydroxo B12 and folinic acid.†
B Complex MF
4.6Rated 4.6 out of 5 stars111 ReviewsFrom $30Key Benefits and Actions† Methyl-free vitamin B complex Supports healthy energy production Supports a healthy mood Who Needs B Complex MF Have...
View full details -
Support healthy methylation and homocysteine levels with a methyl-free Folinic Acid.†
Folinic Acid —Contains a potent dose of 1,360 mcg DFE (800 mcg) of methyl-free folate as folinic acid in a tasty, well-digested form for those sensitive to methylated nutrients.†
Folinic Acid Lozenge
4.8Rated 4.8 out of 5 stars186 ReviewsFrom $20Key Benefits and Actions† Methyl-free folate in a tasty, well-digested lozenge Supports healthy methylation and homocysteine levels Supports hea...
View full details -
Support a healthy lifestyle and balanced diet during pregnancy, especially if you’re methyl-sensitive with Prenatal Essentials MF.†
Prenatal Essentials MF—A concise yet powerful prenatal multivitamin. It supports methylation with bioavailable, methyl-free forms of key pregnancy nutrients.†
Prenatal Essentials MF
5.0Rated 5.0 out of 5 stars104 ReviewsFrom $35Key Benefits and Actions† 2-capsule serving size provides your essential daily prenatal nutrients in methyl-free forms Supports healthy immune, ...
View full details
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Support the healthy conversion of fat into energy with Acetyl-L-Carnitine.†
Acetyl-L-carnitine—A unique, bioavailable amino acid that supports healthy energy production, brain and nervous system function, and fat metabolism.†

Acetyl-L-Carnitine
Key Benefits and Actions† Supports conversion of fat into energy Supports healthy heart, brain, muscle, and sperm function Supports athletic per...
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