The Super 7 Dirty Genes
Discover the seven most important genes that affect your health and learn how to optimize them for better wellness.
MTHFR Gene
The methylenetetrahydrofolate reductase gene plays a crucial role in folate metabolism and methylation processes. This enzyme converts folate into its active form, which is essential for DNA synthesis, repair, and methylation reactions throughout the body.
Strengths
- Efficient folate processing when clean
- Good methylation support with proper nutrients
- Enhanced detoxification pathways
- Optimal DNA synthesis and repair
Weaknesses
- Reduced enzyme activity with variants
- Increased need for methylfolate
- Sensitivity to folic acid supplementation
- Potential homocysteine elevation
COMT Gene
The catechol-O-methyltransferase gene is responsible for breaking down dopamine, norepinephrine, and estrogen. This enzyme plays a vital role in neurotransmitter balance and hormone metabolism, affecting mood, focus, and stress response.
Strengths
- Balanced neurotransmitter levels
- Good stress response
- Efficient hormone metabolism
- Stable mood regulation
Weaknesses
- Slow dopamine clearance with variants
- Increased sensitivity to stress
- Potential estrogen dominance
- Mood fluctuations
DAO Gene
The diamine oxidase gene produces the enzyme responsible for breaking down histamine in the digestive tract. This enzyme is crucial for supporting healthy histamine balance in the body.†
Strengths
- Efficient histamine breakdown
- Good tolerance to histamine-rich foods
- Balanced immune response
- Healthy digestive function†
Weaknesses
- Poor histamine clearance
- Food sensitivities and intolerances
- Increased allergy symptoms
MAOA Gene
The monoamine oxidase A gene breaks down neurotransmitters like serotonin, dopamine, and norepinephrine. This enzyme is important for supporting healthy neurotransmitter balance and emotional regulation.
Strengths
- Balanced mood regulation
- Good neurotransmitter turnover
- Stable emotional responses
- Efficient stress management
Weaknesses
- Altered neurotransmitter metabolism
- Mood sensitivity
- Increased need for B vitamins
- Potential emotional fluctuations
GST/GPX Genes
Glutathione S-transferase and glutathione peroxidase genes are crucial for antioxidant defense and detoxification. These enzymes protect cells from oxidative stress and help eliminate toxins from the body.
Strengths
- Strong antioxidant capacity
- Efficient toxin elimination
- Good cellular protection
- Enhanced immune function
Weaknesses
- Reduced detoxification capacity
- Increased oxidative stress
- Higher need for antioxidants
- Environmental sensitivity
NOS3 Gene
The nitric oxide synthase 3 gene produces nitric oxide, which supports healthy circulation. This enzyme plays a role in regulating blood flow, blood pressure, and vascular function.
Strengths
- Good nitric oxide production
- Healthy blood flow
- Optimal cardiovascular support
- Efficient oxygen delivery
Weaknesses
- Reduced nitric oxide synthesis
- Less efficient circulation
- Challenges for cardiovascular wellness Exercise intolerance
PEMT Gene
The phosphatidylethanolamine N-methyltransferase gene is involved in choline metabolism and liver function. This enzyme helps produce phosphatidylcholine, which is essential for cell membrane integrity and healthy liver activity.
Strengths
- Efficient choline production
- Good liver function
- Healthy cell membrane synthesis
- Optimal brain development
Weaknesses
- Reduced choline synthesis
- Increased dietary choline needs
- Potential liver challenges
- Reduced resilience in fat metabolism
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