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Active B12 with L-5-MTHF - 60 Lozenges

Rated 4.9 out of 5 stars
587 Reviews

Active B12 with L-5-MTHF - 60 Lozenges

Original price $21.95 - Original price $111.96
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$21.95 - $111.96
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  • Bioavailable, methylated folate and B12 in a well-absorbed lozenge
  • Potent methylation, homocysteine, and MTHFR support
  • Supports optimal mental clarity and brain health

Who Needs Active B12 with L-5-MTHF

Do you struggle to get enough B12 or folate?

Do you want to support healthy homocysteine levels?

Do you have concerns about your MTHFR gene?

Would you like to promote optimal energy levels in your body?

Active B12 with L-5-MTHF provides a potent dose of bioavailable folate and vitamin B12 in a delicious, well-absorbed lozenge.

Active B12 with L-5-MTHF supports healthy methylation, homocysteine regulation, and energy production. It provides methylfolate and active B12, which can bypass the MTHFR gene to support genetic mutations.

Active B12 with L-5-MTHF contains:

  • 1,360 mcg DFE (800 mcg) of folate in the active form of L-5-methyltetrahydrofolate (L-5-MTHF or 5-MTHF)
  • 1,000 mg of vitamin B12 in the active forms of methylcobalamin and adenosylcobalamin

Many individuals struggle to adequately absorb folate and B12. Active B12 with L-5-MTHF provides these nutrients in a well-absorbed lozenge for immediate support. These tasty lozenges make getting your daily methylation nutrients delicious!

Formulated without artificial colors, artificial flavors, or cane sugar, they are a top-seller here at Seeking Health for a good reason.

Active B12 with L-5-MTHF supports healthy:

  • Mood
  • Methylation
  • DNA expression
  • Energy production
  • Blood cell formation
  • Homocysteine levels
  • Cardiovascular wellness
  • Cognitive, memory, and brain function
  • Nervous system function and development
  • Prevention of neural tube defects during pregnancy

Active B12 with L-5-MTHF contains methylated forms of folate (methylfolate) and B12 (methylcobalamin). These bioactive forms provide the methyl groups necessary for methylation. The process of methylation supports healthy brain function, a positive mood, and heart health .

Your body requires B12 to utilize folate in the methylation cycle. Both of these critical nutrients are included in Active B12 with L-5-MTHF. This targeted formula is perfect if you are looking for a potent dose of B12 and folate for your methylation-support protocol.

Get ready to start firing on all cylinders. Methylation has never tasted so good!

** Active B12 with L-5-MTHF has met standards for ingredient and product quality for B Vitamins in independent testing. More information at

Customer Review

Active B12 with L-5 MTHF has everything I was looking for in one lozenge.

I’m very satisfied with this supplement as well as the company Seeking Health. I have checked many companies that sell supplements and Seeking Health meets my requirements for a qualified company to include research and quality ingredients. I love having a high dose methylation supplement B12 as well as folate. I am vegan and I’m not always able to eat enough of the appropriate foods to meet the appropriate doses of B12 or folate. I feel assured these needs are met with this product.

Key Ingredients In Active B12 with L-5-MTHF

  • True Folate: Features the methylated form of folate, methylfolate (L-5-MTHF) as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt. Methylfolate is essential for healthy methylation, fetal development, energy, homocysteine regulation, cognition, and much more.
  • Bioavailable B12: A mixture of ‘Adeno’ and ‘Methyl’ forms are included. These coenzymes support energy production and help utilize folate in methylation processes.

Why Active B12 with L-5-MTHF Works

Without sufficient levels of bioavailable folate and B12, methylation is not possible. Methylation supports nearly every biochemical process in your body by determining how your genes are read.

Active B12 with L-5-MTHF was formulated based on enzymatic pathways that are involved in methylation. Enzymes in these pathways require specific nutrients as cofactors. Arguably, the most critical of these nutrients are active and bioavailable forms of folate and B12.

Both methylfolate (folate) and methylcobalamin (B12) play a role in supplying methyl groups for methylation in the human body. Active B12 with L-5-MTHF provides folate and B12 in these superior, bioavailable forms to support healthy methylation and MTHFR genetic mutations.

Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).

MTHFR gene polymorphisms or lifestyle stress can slow down the MTHFR enzyme, causing folate deficiency. It is estimated that over 50% of the population has a gene mutation in their MTHFR gene.

By supplementing with the natural form of folate as L-5-MTHF, you bypass the MTHFR gene. This supports methylation by allowing folate to flow into the methylation pathway via the MTR enzyme.

Ironically, the artificial version of folate that is often prescribed to pregnant women, called folic acid, can further slow the MTHFR gene. This can even lead to folate deficiency! Folic acid is never included in any of Seeking Health’s dietary supplements. Instead, we use natural and bioavailable forms, including L-5-MTHF (methylated) and methyl-free folinic acid.

An important function of methylation is to keep homocysteine levels in normal ranges. Poor metabolism of homocysteine may lead to increased levels. General wellness and cardiovascular health are dependent upon maintaining normal homocysteine levels.

Methylfolate donates its methyl group to cobalamin (B12) to form methylcobalamin. This methyl form of B12 then acts as a methyl donor passing on its methyl group to homocysteine. This transforms homocysteine back into the amino acid methionine. The entire process assures that homocysteine levels stay in a healthy range. Complications may arise when either methylfolate or B12 levels drop, and the cycle does not continue at a normal pace.

L-5-MTHF also supports the production of important mood neurotransmitters. These include dopamine, serotonin, melatonin, epinephrine, and norepinephrine. This is how supplementation with L-5-MTHF can help to support a healthy mood.

Active B12 with L-5-MTHF provides bioavailable folate and vitamin B12 in a delicious, optimally-absorbed lozenge. It’s never been tastier (or easier) to support optimal methylation and energy!

Active B12 with L-5-MTHF
Supplement Facts

Serving Size: 1 Lozenge
Servings Per Container: 60

Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt) 1360 mcg DFE (800 mcg) 340%
Vitamin B12 (80% as methylcobalamin and 20% as adenosylcobalamin) 1000 mcg 41,667%

Other Ingredients: Xylitol, ascorbyl palmitate, natural cherry flavor, and silica.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Lozenges
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use Active B12 with L-5-MTHF

Suggested Use

Take 1 lozenge daily, or use as directed by your healthcare professional. Lozenge may be broken into smaller pieces if lower dosage is desired. Do not take within 5 hours of bedtime as it may interfere with sleep.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. Consult with a healthcare professional before use if you are using antibiotics or other medications. When taking high doses of nutrients such as B12 and folate, monitor blood levels and use under the supervision of a qualified physician.

How to Enhance Active B12 with L-5-MTHF


Consider Pulsing

Dr. Ben Lynch recommends using certain dietary supplements based on your need for them. Start with a partial serving and increase slowly over time to the full serving, only if needed. When you start feeling good, consider reducing the serving size, skipping days, or pausing supplementation. Then take again when you feel you need it (stressful day, traveling, chemical exposure, etc.), hence "pulsing." Work with your qualified healthcare practitioner to determine what's best for you.


Pairs Well With

Optimal Magnesium, to support methylation-dependent enzymes. B Minus, to provide the rest of your essential B vitamins. This formula is free from B12 and folate. PQQ Lozenge, to support oxidative stress levels in your methylation pathways.


Clean Your Genes

After years of suffering from unexplainable health issues, Dr. Ben Lynch, ND discovered the root cause - "dirty" genes. In his best-selling book, Dirty Genes, Dr. Ben Lynch describes the steps you can take to promote optimal epigenetic health. Ready to get started? Click here to take the Dirty Genes Quiz to find which of your genes are dirty!

Why Choose Seeking Health

Here at Seeking Health, we are committed to providing you the best in bioavailable supplements, methylation support, prenatal vitamins, genetic analysis tools, and more.

We strive to go above and beyond the average supplement company, which is why we allocate significant resources to testing all of our supplements for purity, potency, and label claims.

  • Third-party tested for heavy
    metals, microbials, and potency
  • Scientifically formulated by Dr. Ben Lynch, ND
  • Manufactured in the USA from globally
    sourced ingredients
  • Nutrients in their bioavailable
    forms for optimal absorption
  • cGMP facility registered by NSF International
Purity & Potency Tested & Assured
Scientifically Formulated by Dr. Ben Lynch
Manufactured in the USA from globally sourced ingredients third-party independently tested
Bioavailable Nutrients

FAQs for Active B12 with L-5-MTHF

What is the purpose of each ingredient in Active B12 with L-5-MTHF?

Ingredients Purpose
Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt) Supports homocysteine metabolism, methylation processes, and nervous system health
Vitamin B12 (80% as methylcobalamin and 20% as adenosylcobalamin) Helps methylfolate conversion for methylation processes; Supports nervous system and energy

Who is Active B12 with L-5-MTHF intended for?

Active B12 with L-5-MTHF lozenges are intended for those seeking a potent B12 and folate formula to support healthy methylation. It is great for older adults seeking cognition and energy support, those with MTHFR gene concerns, or those wanting to support healthy homocysteine levels.

Which folate is right for me??

Click here to view our Folate Supplement Comparison Chart.

Read this blog: The different forms of folate: which one is right for you?

This blog article explains folic acid side effects.

If you have a question that's not addressed
here, see all frequently asked questions.


Do you have Questions
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What our customers say

Real reviews from real customers.

Rated 4.9 out of 5 stars
Based on 587 reviews
Total 5 star reviews: 544 Total 4 star reviews: 37 Total 3 star reviews: 5 Total 2 star reviews: 0 Total 1 star reviews: 1
99%would recommend this product
587 reviews
  • MY
    Mervat Y.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    18 hours ago
    A must vitamin

    I have MTHFR mutation and my lab test shows every time my B12 deficiency even my diet is animal based but my body can’t absorb it and I have to take the mythelated form to perform otherwise I have no energy weak muscles fatigue and pain ! Thank you

  • MJ
    Mary Jo A.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    Active B12 + L-5-MTHF

    I can skip the nap when I take this. I am a fan.

  • JS
    Judith S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    5 days ago


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These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.