Without sufficient levels of bioavailable folate and B12, methylation is not possible. Methylation supports nearly every biochemical process in your body by determining how your genes are read.†
Active B12 with L-5-MTHF was formulated based on enzymatic pathways that are involved in methylation. Enzymes in these pathways require specific nutrients as cofactors. Arguably, the most critical of these nutrients are active and bioavailable forms of folate and B12.†
Both methylfolate (folate) and methylcobalamin (B12) play a role in supplying methyl groups for methylation in the human body. Active B12 with L-5-MTHF provides folate and B12 in these superior, bioavailable forms to support healthy methylation and MTHFR genetic mutations.†
Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).†
MTHFR gene polymorphisms or lifestyle stress can slow down the MTHFR enzyme, causing folate deficiency. It is estimated that over 50% of the population has a gene mutation in their MTHFR gene.
By supplementing with the natural form of folate as L-5-MTHF, you bypass the MTHFR gene. This supports methylation by allowing folate to flow into the methylation pathway via the MTR enzyme.†
Ironically, the artificial version of folate that is often prescribed to pregnant women, called folic acid, can further slow the MTHFR gene. This can even lead to folate deficiency! Folic acid is never included in any of Seeking Health’s dietary supplements. Instead, we use natural and bioavailable forms, including L-5-MTHF (methylated) and methyl-free folinic acid.†
An important function of methylation is to keep homocysteine levels in normal ranges. Poor metabolism of homocysteine may lead to increased levels. General wellness and cardiovascular health are dependent upon maintaining normal homocysteine levels.†
Methylfolate donates its methyl group to cobalamin (B12) to form methylcobalamin. This methyl form of B12 then acts as a methyl donor passing on its methyl group to homocysteine. This transforms homocysteine back into the amino acid methionine. The entire process assures that homocysteine levels stay in a healthy range. Complications may arise when either methylfolate or B12 levels drop, and the cycle does not continue at a normal pace.†
L-5-MTHF also supports the production of important mood neurotransmitters. These include dopamine, serotonin, melatonin, epinephrine, and norepinephrine. This is how supplementation with L-5-MTHF can help to support a healthy mood.†
Active B12 with L-5-MTHF provides bioavailable folate and vitamin B12 in a delicious, optimally-absorbed lozenge. It’s never been tastier (or easier) to support optimal methylation and energy!†