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Histamine Nutrients (Formerly Histamine Block Plus)

  • Supports a healthy seasonal histamine response, outdoors and indoors
  • Provides nutrients needed to support healthy histamine breakdown
  • You will notice it works quite quickly
This formula contains niacin. When taken on an empty stomach, a healthy response to niacin supplementation may include mild blushing, warming, or tingling of the skin. See below for more details.

Who Needs Histamine Nutrients

Histamine issues are front and center in your life. It seems you cannot get a handle on them.

You’ve realized that you need histamine support beyond just limiting high histamine food and drinks.

Here are some common scenarios which may resonate with you:

  • You love cats and dogs but your body doesn’t let you love them.
  • Some months of the year, you take a step outside and you find yourself sneezing right away. Mowing the lawn or going for a walk outside can really set you off.

Histamine Nutrients contains histamine-processing nutrients which support total body histamine breakdown.

If you relate to one or more of the following statements, then Histamine Nutrients may be helpful for you in supporting healthy histamine levels:

The synergistic blend of nutrients found in Histamine Nutrients supports healthy histamine metabolism. It also supports the body’s normal breakdown of histamine’s toxic byproducts.

Customer Review

Histamine Nutrients

My 10 year old son suffers from seasonal discomfort. Since starting him on Histamine Nutrients, he can now play outdoors all day and fall asleep easily. My husband has had support from it as well since taking these, too! I love how you don’t have to take it everyday as well! Definitely recommended for anyone experiencing seasonal discomfort! - Holly

Key Ingredients In Histamine Nutrients

  • DAO2TM (Diamine oxidase): A patented, porcine-derived enzyme. DAO is the enzyme responsible for breaking down histamine in the digestive tract
  • Zinc, Vitamins B1 & B3: Nutrient cofactors for aldehyde metabolism and the ALDH enzyme
  • SAMe: A cofactor for the HNMT enzyme that breaks down histamine throughout the body
  • Alpha Keto-Glutarate: Supports the normal breakdown of ammonia, a toxic byproduct of histamine metabolism
  • PQQ: supports normal breakdown of hydrogen peroxide and aldehydes
  • Vitamin C: stabilizes mast cells to support healthy histamine release
  • Vitamin B6: a cofactor for the DAO enzyme and supports healthy ammonia levels
  • Vitamin B5 (pantothenic acid): a cofactor for the NAT2 enzyme, which metabolizes histamine to acetyl histamine and eliminates it in the urine

Why Histamine Nutrients Works

In order for your body to have healthy histamine levels, you have to provide very specific nutrients. If you are lacking in even just one nutrient, your histamine levels will be problematic for you.

This is likely why histamine intolerance is such a common issue. It just takes one nutrient deficiency.

Here's why.

Histamine is a compound that requires destruction by multiple enzymes. These enzymes require specific nutrients. Think of it like an assembly line. If one worker gets overwhelmed, or doesn't have the right tools for the job, everything gets backed up.

Histamine Nutrients is the first, and likely only, supplement which supports all the histamine breakdown enzymes in your body. All of them. There are five enzymes which break apart histamine and eliminate it from your body. As mentioned before, you have to have ALL 5 enzymes working together simultaneously. If you don’t, you will not achieve healthy histamine levels.

Here are your five histamine breakdown enzymes:

  1. HNMT: this requires SAMe to initiate the first step of histamine breakdown into methylhistamine. HNMT is found heavily in your brain, uterus and liver.
  2. MAOA and MAOB: these two enzymes both require vitamin B2. These two enzymes process the methylhistamine made by HNMT.
  3. ALDH: this enzyme requires zinc, niacin and vitamin B1. This enzyme processes the compounds made by your MAOA, MAOB and DAO enzymes.
  4. DAO: this enzyme requires copper and vitamin B6. This enzyme processes histamine found in the digestive tract, placenta, bladder and many other areas.



It's not that easy.

As these enzymes work in breaking down histamine, they create the toxic compounds of ammonia, hydrogen peroxide, and acetaldehyde. These compounds must be broken down by additional enzymes. These enzymes require alpha keto-glutarate, thiamine and PQQ.

Next time you want to support healthy levels of histamine, and the elimination of the toxic byproducts, take 2 capsules of Histamine Nutrients anytime you need it - day or night. You will notice that it acts quite quickly.

Histamine Nutrients
Supplement Facts

Serving Size: 2 Capsules
Servings Per Container: 30

Vitamin C (as ascorbic acid) 100 mg 111%
Thiamine (as thiamine hydrochloride) 20 mg 1,667%
Riboflavin (as riboflavin 5'-phosphate sodium) 10 mg 769%
Niacin (as nicotinic acid) 25 mg 156%
Vitamin B6 (as pyridoxal 5'-phosphate) 7 mg 412%
Pantothenic Acid (as d-calcium pantothenate) 10 mg 200%
Magnesium (as DiMagnesium Malate)(Albion®) 50 mg 12%
Zinc (as zinc gluconate) 5 mg 45%
Copper (as copper gluconate) 0.5 mg 56%
Alpha-Ketoglutaric Acid 150 mg **
SAMe (as disulfate ptoluensulfonate) 100 mg **
PQQ (as LifePQQTM pyrroloquinoline quinone disodium salt) 7 mg **
DAO2TM porcine kidney extract (Diamine Oxidase Activity 5,000 HDU) 2.1 mg **
**Daily Value (DV) not established.

Other Ingredients: vegetarian capsule (hypromellose, water, and gellan gum), ascorbyl palmitate, microcrystalline cellulose and silica.
Albion® is a registered trademark of Balchem Corporation or its subsidiaries.
DAO2TM is a licensed trademark of Diem Direct, LLC used with permission.

    NOT Suitable for Vegetarians or Vegans
  • Delivery Method: Capsules
  • How To Store: Keep tightly closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use Histamine Nutrients

Suggested Use

Take 2 capsules, as needed, with or without food, or use as directed by your healthcare professional.


Histamine Nutrients is NOT EFFECTIVE for symptoms of immune-related (antibody- or IgE-related) food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. Do not use if inner tamper seal is damaged.
Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient.

Niacin Flushing: This formula contains niacin. When taken on an empty stomach, a healthy response to niacin supplementation may include mild blushing, warming, or tingling of the skin. This can appear on the ears, face, arms, torso, or occasionally on the legs. Commonly referred to as a "niacin flush", this harmless response normally dissipates within an hour. It is related to niacin's role in vasodilation (widening of blood vessels). Vasodilation leads to better circulation, capillary flushing, and increased blood flow to the surface of the skin. To minimize or prevent flushing, consider taking this supplement with food or in divided doses.

FAQs for Histamine Nutrients

What is the purpose of each ingredient in Histamine Nutrients?

Ingredients Purpose
Vitamin C Supports healthy DAO production, normal histamine breakdown, and normal inflammatory processes
Thiamine Is often depleted in the presence of high aldehyde levels and other histamine byproducts
Niacin Plays a role in increasing the activity of the ALDH enzyme family to support the normal regulation of acetaldehyde concentrations
Vitamin B6 Works with DAO to help support the normal breakdown of histamine
Pantothenic Acid Cofactor for the NAT2 enzyme, which metabolizes histamine to acetylhistamine
Magnesium (as Di-Magnesium Malate) (Albion®) Supports normal glutamate response from ammonia release. Ammonia is released from histamine metabolism
Zinc Cofactor for the ALDH enzyme family
Copper Cofactor for the DAO enzyme
Alpha-Ketoglutaric Acid Supports normal ammonia breakdown, which is created from histamine metabolism
SAMe Cofactor for the HNMT enzyme, which is a major enzyme in histamine breakdown
PQQ Supports healthy oxidative stress responses
DAO (porcine extract) The enzyme that supports healthy breakdown of histamine from food

Why is Histamine Nutrients not suitable for vegans or vegetarians?

Histamine Nutrients contains porcine-derived ingredients.

Which histamine product is right for me?

Check out this Histamine Supplement Comparison Chart..

If you have a question that's not addressed
here, see all frequently asked questions.


Do you have Questions
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What our customers say

Real reviews from real customers.

Rated 4.7 out of 5 stars
Based on 188 reviews
Total 5 star reviews: 166 Total 4 star reviews: 9 Total 3 star reviews: 6 Total 2 star reviews: 1 Total 1 star reviews: 6
95%would recommend this product
188 reviews
  • MF
    Michelle F.
    Verified Buyer
    I do not recommend this product
    Rated 1 out of 5 stars
    3 weeks ago
    Price has tripled!!

    The new jar looks bigger, but don’t be fooled. Only 30 servings compared to 90 servings in the old formula. Really not cool!

    SH Profile picture for Seeking Health
    Seeking Health

    Hello Michelle,

    The Histamine Nutrients and the Histamine Block (now being renamed as Histamine Digest) are 2 different products.

    The Histamine Nutrients comes in 60 capsules.

    The Histamine Digest comes in a 30 or 90 bottle.


  • RK Profile picture for Renee logo
    Renee K.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Prolonged out of stock, disturbing

    This product along with HistaminX helped me get through Spring/Fall pollen season. My histamine intolerance very difficult to control when pollen counts high and now living in SC instead of NY the season here much longer. Did much better with use of these products. Been trying to reorder both for quite a while, they remain out of stock. Trying to replicate by taking separate components which means lots more capsules. DAO alone also does nothing for me as my issues more HNMT caused.

  • S
    Verified Reviewer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Mayday mayday

    I’m a bit in dispair 😓

    I can not order anywhere in the whole world histamine block plus anymore…

    I really can not live a normal life without it ?

    Is there something going on ?

    Without them i am really in bed all day.

    I am from Belgium.

    Hope they Will be available soon 😖

    Please keep up with this amazing product 🙏🏻

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These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.