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Out of Stock
  • Healthy immune system support
  • Support for healthy lungs, nose, and airway
  • Supports healthy inflammatory responses
This product is temporarily out of stock. For the same great histamine support with a similar formula, try ProBiota HistaminX Capsules.
NEW & IMPROVED FORMULA.- In order to bring you the best quality possible, this product has been reformulated. To learn more about these changes, please click here.

Who Needs HistaminX

Watery eyes, sinus issues, sneezing, runny nose, any of these sound familiar?

When springtime rolls around and pollen levels are high, do you find yourself wanting to hide indoors?

Your immune system normally produces inflammation in your body. However, if immune function is imbalanced, it can trigger inflammation and side effects in your nose, eyes, or lungs.

HistaminX is a targeted formula for immune health and seasonal comfort. It features herbal and plant-derived compounds that synergistically support healthy inflammatory responses.

If you can relate to one or more of the following statements, then HistaminX may be helpful for you in supporting a healthy immune response to your environment:

  • I would like to support my seasonal wellness
  • I experience sinus problems in response to my environment
  • I get red/watery eyes in response to my environment
  • I would like to support healthy histamine storage and release
  • I would like to support healthy inflammatory responses
  • I experience histamine related symptoms when I am around cats or dogs
  • I experience seasonal wellness related issues like sinus or skin problems
  • I currently use Histamine Block, Histamine Block Plus, or Probiota HistaminX and would like additional histamine support
  • I would like to support the health of my mucous membranes

Dietary changes, exposure to pollen, and stress all impact your ability to maintain healthy levels of inflammation and fight off invaders. The bioflavonoids, enzymes, and other plant compounds found in HistaminX work together to support a healthy immune system and inflammatory response. Now you can enjoy time outdoors again with this unique targeted formula!

Customer Review

Great Product

Works like a charm! Finally on a great vitamin routine! ~Kayla S.

Key Ingredients In HistaminX

  • Glucoraphanin: A powerful antioxidant-like ingredient derived from broccoli that is converted to sulforaphane in the body; Sulforaphane supports phase II liver detoxification and a healthy response to oxidative stress.
  • Stinging nettle: Supports healthy inflammatory responses and respiratory tract wellness.
  • Bromelain: An enzyme from pineapple that supports healthy inflammatory processes and healthy lungs and airways
  • Quercetin, Luteolin & Rutin: Flavonoids that possess powerful antioxidant properties and health benefits including immune support; They also support healthy histamine and inflammatory responses

Why HistaminX Works

Within the human body, histamine is stored in immune cells called mast cells and basophils. Signals from the environment such as infections, inflammatory foods, and toxins can excite these cells, causing them to release histamine. However, in the presence of certain plant compounds, mast cells are less likely to release their histamine.

HistaminX contains complementary plant compounds that support healthy mast cell function and normal histamine storage and release.

Bioflavonoids (or simply flavonoids) are a type of compound synthesized by plants. They are attributed to the potential benefits of a plant-rich diet. Compounds in this family may help support healthy inflammatory responses, cellular health, and cellular signaling.

HistaminX features the plant flavonoids luteolin, quercetin, and rutin. These antioxidant-like compounds may help modulate the body’s histamine response by supporting mast cells and healthy levels of histamine.

Stinging nettle leaves have been traditionally used to support respiratory, urinary, and mucus membrane health.

Bromelain, a proteolytic enzyme found in pineapple, is used as a digestive enzyme. It is also thought to help support normal inflammatory and healing responses.

Glucoraphanin is a compound found in plants in the genus Brassica (e.g. broccoli and cauliflower). It is thought to support healthy detoxification processes, a strong immune system, and provide mitochondrial support.

The herbal compounds in HistaminX work to synergically support your seasonal comfort, respiratory, and immune health. Get ready to enjoy the outdoors again, all year long!

Supplement Facts

Serving Size: 2 Capsules
Servings Per Container: 30

Stinging Nettle Extract (Urtica dioica)(aerial parts) 200 mg **
Luteolin [from Sophora japonica(bud)] 100 mg **
Rutin [from Sophora japonica(bud)] 100 mg **
Quercetin [as quercetin dihydrate from Sophora japonica)(bud)] 150 mg **
Bromelain [(from pineapple)(stem)(2,400 GDU/g)] 100 mg **
Glucoraphanin [from broccoli extract)(Brassica oleracea italica)(seed)(TrueBroc®)] 25 mg **
% DV (Daily Value) based on standard 2,000 calorie daily intake
**Daily Value not established

Other Ingredients: vegetarian capsule (hypromellose and water), microcrystalline cellulose, L-leucine, and ascorbyl palmitate.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Capsules
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use HistaminX

Suggested Use

Take 2 capsules without food or as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.

FAQs for HistaminX

What is the purpose of each ingredient in HistaminX?

Ingredients Purpose
Stinging Nettle Extract Supports healthy inflammatory responses and respiratory tract health
Luteolin, Rutin, Quercetin Flavonoids that support healthy inflammatory, histamine, and immune responses
Bromelain An enzyme from pineapple that supports healthy inflammatory processes, lungs, and airways
Glucoraphanin A powerful antioxidant derived from broccoli that supports phase II liver detoxification and healthy responses to oxidative stress

Who is HistaminX intended for?

HistaminX is intended for those seeking to support the health of their respiratory tract, eyes, gastrointestinal tract, and other mucous membranes, and to support normal immune system defenses.

Which histamine product is right for me?

Check out this Histamine Supplement Comparison Chart.

For more detailed information, check out this article about our Top 5 Histamine Intolerance Products

If you have a question that's not addressed
here, see all frequently asked questions.


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What our customers say

Real reviews from real customers.

Rated 4.7 out of 5 stars
Based on 137 reviews
Total 5 star reviews: 113 Total 4 star reviews: 13 Total 3 star reviews: 7 Total 2 star reviews: 1 Total 1 star reviews: 3
93%would recommend this product
137 reviews
  • R
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 hours ago

    This product helps me so much but I've been out for a while and now suffering again. So you have anything similar? When do you expect this one to be back in stock? Thank you!

  • P Profile picture for Presouzgoogle logo
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 weeks ago

    I believe this is now called Histamine digest. That’s why Histamine X is out of stock. It no longer is called that.

  • D
    I recommend this product
    Rated 4 out of 5 stars
    2 weeks ago
    Out of stock for months?

    This product has been out of stock for close to a year! Seriously? For those who use this in their regular supplement routine this is highly unacceptable. Get your logistics together!

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These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.