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Methyl B12 with L-Methylfolate

  • Active, methylated folate and B12 in a well-absorbed lozenge
  • Potent methylation, homocysteine, and MTHFR support
  • Supports optimal mental clarity and brain health

Who Needs Methyl B12 with L-Methylfolate

Do you struggle to get enough B12 or folate?

Do you want to support healthy homocysteine levels?

Do you have concerns about your MTHFR gene?

Would you like to promote optimal energy levels in your body?

Methyl B12 with L-Methylfolate provides a potent dose of bioavailable folate and vitamin B12 in a delicious, well-absorbed lozenge.

Methyl B12 with L-Methylfolate supports healthy methylation, homocysteine regulation, and energy production. It provides methylfolate and active B12, which can bypass the MTHFR gene to support genetic mutations.

Methyl B12 with L-Methylfolate contains:

  • 1,360 mcg DFE (800 mcg) of folate in the active form of L-5-methyltetrahydrofolate (L-5-MTHF or 5-MTHF)
  • 1,000 mg of vitamin B12 in the active forms of methylcobalamin and adenosylcobalamin

Many individuals struggle to adequately absorb folate and B12. Methyl B12 with L-Methylfolate provides these nutrients in a well-absorbed lozenge for immediate support. These tasty lozenges make getting your daily methylation nutrients delicious!

Formulated without artificial colors, artificial flavors, or cane sugar, they are a top-seller here at Seeking Health for a good reason.

Methyl B12 with L-Methylfolate supports healthy:

  • Mood
  • Methylation
  • DNA expression
  • Energy production
  • Blood cell formation
  • Homocysteine levels
  • Cardiovascular wellness
  • Cognitive, memory, and brain function
  • Nervous system function and development
  • Prevention of neural tube defects during pregnancy

Methyl B12 with L-Methylfolate contains methylated forms of folate (methylfolate) and B12 (methylcobalamin). These bioactive forms provide the methyl groups necessary for methylation. The process of methylation supports healthy brain function, a positive mood, and heart health .

Your body requires B12 to utilize folate in the methylation cycle. Both of these critical nutrients are included in Methyl B12 with L-Methylfolate. This targeted formula is perfect if you are looking for a potent dose of B12 and folate for your methylation-support protocol.

Get ready to start firing on all cylinders. Methylation has never tasted so good!

Customer Review

Active B12 with L-5 MTHF has everything I was looking for in one lozenge.

I’m very satisfied with this supplement as well as the company Seeking Health. I have checked many companies that sell supplements and Seeking Health meets my requirements for a qualified company to include research and quality ingredients. I love having a high dose methylation supplement B12 as well as folate. I am vegan and I’m not always able to eat enough of the appropriate foods to meet the appropriate doses of B12 or folate. I feel assured these needs are met with this product.

Key Ingredients In Methyl B12 with L-Methylfolate

  • True Folate: Features the methylated form of folate, methylfolate (L-5-MTHF) as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt. Methylfolate is essential for healthy methylation, fetal development, energy, homocysteine regulation, cognition, and much more.
  • Bioavailable B12: A mixture of ‘Adeno’ and ‘Methyl’ forms are included. These coenzymes support energy production and help utilize folate in methylation processes.

Why Methyl B12 with L-Methylfolate Works

Without sufficient levels of bioavailable folate and B12, methylation is not possible. Methylation supports nearly every biochemical process in your body by determining how your genes are read.

Methyl B12 with L-Methylfolate was formulated based on enzymatic pathways that are involved in methylation. Enzymes in these pathways require specific nutrients as cofactors. Arguably, the most critical of these nutrients are active and bioavailable forms of folate and B12.

Both methylfolate (folate) and methylcobalamin (B12) play a role in supplying methyl groups for methylation in the human body. Methyl B12 with L-Methylfolate provides folate and B12 in these superior, bioavailable forms to support healthy methylation and MTHFR genetic mutations.

Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).

MTHFR gene polymorphisms or lifestyle stress can slow down the MTHFR enzyme, causing folate deficiency. It is estimated that over 50% of the population has a gene mutation in their MTHFR gene.

By supplementing with the natural form of folate as L-5-MTHF, you bypass the MTHFR gene. This supports methylation by allowing folate to flow into the methylation pathway via the MTR enzyme.

Ironically, the artificial version of folate that is often prescribed to pregnant women, called folic acid, can further slow the MTHFR gene. This can even lead to folate deficiency! Folic acid is never included in any of Seeking Health’s dietary supplements. Instead, we use natural and bioavailable forms, including L-5-MTHF (methylated) and methyl-free folinic acid.

An important function of methylation is to keep homocysteine levels in normal ranges. Poor metabolism of homocysteine may lead to increased levels. General wellness and cardiovascular health are dependent upon maintaining normal homocysteine levels.

Methylfolate donates its methyl group to cobalamin (B12) to form methylcobalamin. This methyl form of B12 then acts as a methyl donor passing on its methyl group to homocysteine. This transforms homocysteine back into the amino acid methionine. The entire process assures that homocysteine levels stay in a healthy range. Complications may arise when either methylfolate or B12 levels drop, and the cycle does not continue at a normal pace.

L-5-MTHF also supports the production of important mood neurotransmitters. These include dopamine, serotonin, melatonin, epinephrine, and norepinephrine. This is how supplementation with L-5-MTHF can help to support a healthy mood.

Methyl B12 with L-Methylfolate provides bioavailable folate and vitamin B12 in a delicious, optimally-absorbed lozenge. It’s never been tastier (or easier) to support optimal methylation and energy!

Methyl B12 with L-Methylfolate
Supplement Facts

Serving Size: 1 Lozenge
Servings Per Container: 60

Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt) 1360 mcg DFE (800 mcg) 340%
Vitamin B12 (as MECOBALACTIVE methylcobalamin and adenosylcobalamin) 1000 mcg 41,667%

Other Ingredients: Xylitol, ascorbyl palmitate, natural cherry flavor, and silica.

  • Suitable For: Vegetarians and Vegans
  • Age Suitability: Adults
  • Delivery Method: Lozenges
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use Methyl B12 with L-Methylfolate

Suggested Use

Initial use for the first week, take 1/2 a lozenge by mouth, let dissolve slowly, then swallow. If needing more support, increase to 1 full lozenge. Take as needed. Do not take within 5 hours of bedtime as it may interfere with sleep. Use as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. Consult with a healthcare professional before use if you are using antibiotics or other medications. When taking high doses of nutrients such as B12 and folate, monitor blood levels and use under the supervision of a qualified physician.

Suitable for


Delivery Method


How to Store

Keep closed in a cool, dry place out of reach by children.

FAQs for Methyl B12 with L-Methylfolate

What is the purpose of each ingredient in Methyl B12 with L-Methylfolate ?

Ingredients Purpose
Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt) Supports homocysteine metabolism, methylation processes, and nervous system health
Vitamin B12 (80% as methylcobalamin and 20% as adenosylcobalamin) Helps methylfolate conversion for methylation processes; Supports nervous system and energy

Who is Methyl B12 with L-Methylfolate intended for?

Methyl B12 with L-Methylfolate lozenges are intended for those seeking a potent B12 and folate formula to support healthy methylation. It is great for older adults seeking cognition and energy support, those with MTHFR gene concerns, or those wanting to support healthy homocysteine levels.

Which folate is right for me??

Click here to view our Folate Supplement Comparison Chart.

Read this blog: The different forms of folate: which one is right for you?

This blog article explains folic acid side effects.

If you have a question that's not addressed
here, see all frequently asked questions.


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What our customers say

Real reviews from real customers.

Rated 4.9 out of 5 stars
Based on 663 reviews
Total 5 star reviews: 616 Total 4 star reviews: 40 Total 3 star reviews: 6 Total 2 star reviews: 0 Total 1 star reviews: 1
98%would recommend this product
663 reviews
  • LP
    Lisa P.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    21 hours ago
    Love the se B Vit Tabs!

    Tasty and easy to take. Start my day with it every day!

  • DM
    Debra M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    Very good supplement!

    We appreciate all of Seeking Health supplements. Very high quality and the lozenges are easy to take without adding more capsules to our regimen. Thank you!

  • VR
    Vanessa R.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    5 days ago
    Noticeable difference

    My husband has notice a big difference in how he feels when he takes this. We practice the pulse method, but one time he ran out for a longer period of time and noticed he wasn’t feeling great.

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