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P-5-P (Pyridoxal 5-Phosphate)
5 Stars
Recommended By My Doc

I take vitamin B individually because I can't seem to take any B complex, especially B12. Thanks to Seeking Health, I can take this to supplement one of the Vitamin B groups. ~Junghun Y.

P-5-P (Pyridoxal 5-Phosphate)

$20 - $120
$60
$20
$20.00 - $102.00
$20

Key Benefits:†

  • Active, bioavailable form of vitamin B6
  • Homocysteine metabolism support
  • Supports a healthy mood
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Recommended By My Doc

I take vitamin B individually because I can't seem to take any B complex, especially B12. Thanks to Seeking Health, I can take this to supplement one of the Vitamin B groups. ~Junghun Y.

Vitamin B6 (or pyridoxine) is an essential nutrient that supports numerous functions in your body.

It’s needed to metabolize homocysteine, normalize mood, balance hormones, and help you sleep.†

Vitamin B6 deficiency has been associated with problems involving the menstrual cycle, heart health, and mood.

Unfortunately, many people have trouble converting food sources of vitamin B6 into its active form, known as pyridoxal 5’-phosphate or P-5-P. These individuals may benefit from P-5-P dietary supplements.†

Seeking Health’s P-5-P contains a potent 25 mg of vitamin B6 (1,471% Daily Value) in the active form of P-5-P (pyridoxal 5’-phosphate).†

This high-strength vitamin B6 supplement is gluten-free and ideal for those deficient or requiring higher amounts. It can be a great addition to your daily multivitamin or B-complex supplement.†

P-5-P is considered by many to be the best vitamin B6 form. Vitamin B6 must have a phosphate group attached for it to bind to enzymes. P-5-P is considered an active coenzyme form of vitamin B6. It activates over 140 different enzymatic reactions in the body. Like the other B complex vitamins, you must obtain this water-soluble vitamin daily from food. This is because your body does not make it.†

Vitamin B6 is required for healthy:†

  • Breakdown of amino acids, carbohydrates, and fats
  • Energy production/energy metabolism
  • Immune system function
  • Brain function
  • Central nervous system function
  • Red blood cells and red blood cell function
  • Methylation processes
  • Many enzymatic reactions

P-5-P pairs well with magnesium to promote healthy female menstrual cycles, neurotransmitter function, and hormone metabolism prior to menstruation. It may also support stomach comfort and digestion due to occasional nausea or morning sickness.†

It can be challenging to get enough vitamin B6 from foods alone. Seeking Health’s P-5-P delivers a high-quality form of vitamin B6 in a convenient capsule. For a complete B complex containing active forms of folate and vitamin B12, consider B Complex Plus.†

Key Ingredients

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  • P-5-P (pyridoxal-5’-phosphate)
    The active, readily available coenzyme form of vitamin B6 plays a role in neurotransmitter metabolism and supporting a healthy mood. P-5-P also supports the healthy metabolism of hormones, homocysteine, sulfur, amino acids, and over 140 different enzymatic reactions in the body.†

Suggested Use

As needed, take 1 capsule with food anytime of day or night. Use as directed by a healthcare provider.

Suitable for

Bariatric, methyl sensitive, pregnancy, breastfeeding, vegetarian, vegan, ages 4 and up

Delivery Method

Capsules

Age Suitability

Adults, ages 4 and up

How to Store

Keep closed in a cool, dry place out of reach of children.

What our customers say

Real reviews from real customers.

4.9
Rated 4.9 out of 5 stars
Based on 119 reviews
Total 5 star reviews: 109 Total 4 star reviews: 8 Total 3 star reviews: 1 Total 2 star reviews: 0 Total 1 star reviews: 1
97%would recommend this product
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119 reviews
  • JB
    Jeanne B.
    Verified Buyer
    Rated 3 out of 5 stars
    3 days ago
    I find it OK

    I am not exactly sure of what P-5-P is doing for me. However, my doctor wants me to take 2 each week and so I am. Maybe after my next blood tests we will know how well it is working. I personally can not tell any difference.

    Was this helpful?
    SH Profile picture for Seeking Health
    Seeking Health
    21 seconds ago

    Jeanne,

    Thank you for sharing your experience and for giving this product a try.
    It’s completely understandable not to notice an immediate or obvious difference—P-5-P (the active form of vitamin B6) often works behind the scenes, supporting metabolic and enzymatic processes rather than creating a noticeable “feeling.” Many people use it based on lab markers or practitioner guidance rather than day-to-day sensations.
    We’re glad to hear you’re working closely with your doctor and using blood testing to guide your approach. That’s often the best way to assess how a nutrient like this is supporting your individual needs over time.
    If you ever have questions about the product, our team is always happy to help. We truly appreciate you taking the time to share your feedback.

  • RW
    Reaghan W.
    Verified Buyer
    I recommend this product
    Rated 4 out of 5 stars
    6 days ago
    Still accessing

    I added this to see if i could improve overall energy. I'm still accessing how this has helped in my daily routine. I haven't noticed anything negative. I would say the affects are subtle which is good but could get overlooked.

    Was this helpful?
  • R
    Rachelle
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    I really like this

    I am very particular on the vitamins and supplements I choose. This has been gentle on my stomach and effective for my health. I would highly recommend

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