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  • Includes the biologically active form of riboflavin as R-5-P (Riboflavin 5’-Phosphate)
  • Supports MTHFR, MAOA, and GSR gene function
  • Healthy homocysteine, neurotransmitter, antioxidant, and methylation support

Who Needs Riboflavin

Do you have an MTHFR mutation? High homocysteine? Low energy? A slow MAOA gene?

You might have an increased physiological need for riboflavin (vitamin B2).

Riboflavin by Seeking Health contains a potent 400 mg of riboflavin per vegan-friendly capsule. Vitamin B2 is provided in the active and bioavailable form of riboflavin-5-phosphate (R-5-P).

Riboflavin 5’-Phosphate (R-5-P) is the bioactive form of riboflavin (vitamin B2). Compared to common riboflavin supplements, this form is better absorbed and has more biological activity in the body. Our formula features a mixture of riboflavin and R-5-P. It provides extra support those who struggle to convert riboflavin into its active form.

Riboflavin plays many essential roles in the body.

  • Helps to break down carbs, proteins, and fats
  • Helps to release energy from foods
  • Needed to activate and create many other B vitamins
  • Required for proper methylation processes
  • Important cofactor for the MTHFR gene
  • Needed to produce methylfolate, and therefore support homocysteine breakdown
  • Cofactor for the MAOA enzyme, which metabolizes serotonin and dopamine
  • Needed to recycle glutathione, which acts as your body’s master antioxidant
  • Required by enzymes involved in energy production
  • Needed for healthy fetus development during pregnancy
  • Supports healthy mood and cognition
  • Necessary for your genes to express accurately
  • Healthy growth and development, normal red blood cell production, and many more critical functions are dependent on this B vitamin

Riboflavin deficiency can result in high homocysteine levels and low methylfolate levels. Low levels of riboflavin are known to cause flaky scalp, red or cracked corners of the mouth, hair loss, reproductive issues, and swollen throat and mouth.

This essential B vitamin is necessary to recycle your body’s ‘master’ antioxidant for healthy aging and energy. It is also needed for your MTHFR enzyme to produce methylfolate and to metabolize homocysteine.

Riboflavin by Seeking Health supports healthy:

  • Aging
  • Energy levels
  • Blood pressure levels
  • Carb, protein, fat breakdown
  • Growth & development
  • Red blood cell production
  • Oxygen transport to cells
  • Neurotransmitter balance
  • Cardiovascular health
  • Homocysteine metabolism
  • Methylation & MTHFR function

If you’re seeking a potent and bioactive form of vitamin B2, look no further than Riboflavin capsules by Seeking Health.

Customer Review


Definitely works and I appreciate how clean the supplements are. No weird binders or fillers. ~Shanon H.

Key Ingredients In Riboflavin

  • Riboflavin (as a mixture of riboflavin and R-5-P): This essential B vitamin is also known as vitamin B2. It is responsible for converting and activating many other vitamins in the body, breaking down carbs, homocysteine regulation, and metabolizing certain neurotransmitters. The active, readily available form of riboflavin is called riboflavin-5'-phosphate (R-5-P). This formula features a potent amount of R-5-P to support those who struggle to convert riboflavin into its active form.

Why Riboflavin Works

Riboflavin is a water-soluble B complex vitamin. It is found in whole grains, green vegetables, dairy products, and most multivitamins. Like other water soluble vitamins, your body does not store adequate amounts of riboflavin. It must be consumed daily to meet the recommended dietary allowance (RDA) of 1.3 mg of riboflavin per day (ages 4+).


More than 90% of the riboflavin in your body is in the form of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). Riboflavin is a critical component of these coenzymes. Without it, they could not function. FAD and FMN are called flavoproteins or flavoenzymes (‘flavo’ means they require riboflavin). The flavin ring of riboflavin has a bright yellow color. Interestingly, it is the flavin ring in riboflavin that lends to the bright yellow or yellow/orange urine that can accompany riboflavin supplementation.

FAD/FADH plays a huge role in energy production via the breakdown of carbohydrates, proteins, and lipids. By transporting electrons from the Krebs cycle to the electron transport chain (ETC), FAD is central to energy production. Both FAD and FMN participate in liver detoxification reactions as a cofactor for cytochrome P-450 enzymes.

FMN is another name for riboflavin-5’-phosphate. It plays a key role in multiple enzymes including the transformation of NADH to NAD+ which is needed in many places where an electron must be passed on for important functions in the cell. Without NADH dehydrogenase, and FADH (which are both reliant on riboflavin to function), the electron transport chain could not produce ATP and the cell would die.

MTHFR gene mutations

Riboflavin is required for optimal MTHFR function. Likewise, when riboflavin levels are reduced, so is MTHFR enzyme function. Research indicates that improving riboflavin status may improve the activity of MTHFR.

The MTHFR gene (and the enzymes it produces) are slow functioning in about 50% of the population. Those affected may struggle to convert folate into its active form of 5-methyltetrahydrofolate (5-MTHF). Methylfolate goes on to donate its methyl groups for methylation processes. Without adequate riboflavin, methylfolate cannot be produced. This can worsen MTHFR gene mutation expression.

Homocysteine breakdown

Dysfunctional MTHFR enzymes can also lead to elevated homocysteine levels, a risk factor for cardiovascular issues. MTHFR is a flavoenzyme. It requires riboflavin to convert 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate. The latter serves as a methyl group donor in the conversion of homocysteine to methionine.


Riboflavin is also a cofactor for the MAOA enzyme. This enzyme helps to metabolize serotonin, dopamine, and other catecholamines. MAOA function can be slowed due to genetic mutations. This can lead to issues in breaking down certain neurotransmitters. The end result may be irritability and restless feelings. Those with slow MAOA function may benefit from riboflavin support.

Antioxidant functions

Glutathione acts as your body’s master antioxidant. The enzyme glutathione reductase (GR) requires riboflavin as a cofactor. This FAD-dependent enzyme recycles glutathione after its been used. Recycling glutathione back into its reduced, active form allows it to be reused in redox and detox reactions.

Tryptophan metabolism

The niacin-containing coenzymes, NAD and NADP, can be synthesized from the amino acid tryptophan. Their synthesis requires a FAD-dependent enzyme called kynurenine 3-monooxygenase (KMO). Riboflavin deficiency can lead to niacin deficiency by decreasing the conversion of tryptophan to these important niacin-dependent coenzymes. Riboflavin deficiency has been shown to lead to the decreased conversion of tryptophan to niacin.

Seeking Health’s Riboflavin delivers a potent dose of riboflavin in a vegan-friendly capsule. It provides both a pre-phosphorylated form and a phosphorylated riboflavin called riboflavin 5’-phosphate (R-5-P).

The R-5-P form is known as the active and superior form of riboflavin. In order for your body to convert riboflavin into the active form of R-5-P, it requires the phosphorylation of riboflavin which necessitates ample ATP and functional enzymes. This formula features a potent amount of R-5-P to provide extra support those who struggle to convert riboflavin into its active form.

If you’re looking to support healthy vitamin B2 levels, look no further than Riboflavin capsules by Seeking Health.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60

Riboflavin (as riboflavin and riboflavin-5'-phosphate sodium) 400 mg 30,769%

Other Ingredients: Vegetarian capsule (hypromellose and water), ascorbyl palmitate, and silica.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Capsules
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Corn, Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, and Artificial Flavors

How to Use Riboflavin

Suggested Use

As needed, take 1 capsule with or without food any time of day. Use as directed by your healthcare professional.
Note: Riboflavin may naturally make your urine brighter yellow than typical, especially at higher amounts. This is to be expected, normal and no cause for concern.


Consult with your healthcare professional prior to use. Do not use if tamper seal is damaged.

FAQs for Riboflavin

What is the purpose of each ingredient in Riboflavin?

Ingredients Purpose
Riboflavin Supports healthy growth and development, energy production, carbohydrate, protein, and lipid metabolism, and healthy tryptophan metabolism

Who is Riboflavin intended for?

Riboflavin is intended for those seeking a very potent serving of riboflavin (vitamin B2) in a convenient capsule.

This product may be used in a variety of protocols by your healthcare professional. It is involved in many enzymatic reactions, including serotonin and dopamine regulation, red blood cell production, carbohydrate metabolism, and much more.

How to use Riboflavin?

As needed, take 1 capsule with or without food any time of day. Use as directed by your healthcare professional. Note: Riboflavin may naturally make your urine brighter yellow than typical, especially at higher amounts. This is to be expected, normal and no cause for concern.

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What our customers say

Real reviews from real customers.

Rated 4.9 out of 5 stars
Based on 85 reviews
Total 5 star reviews: 77 Total 4 star reviews: 8 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 0
99%would recommend this product
85 reviews
  • A Profile picture for Andrea
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 hour ago

    I've recently learned how important b2 is for mthfr. Glad this is in the biologically active form!

  • AM
    Alina M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    Great vitamin B2!

    It’s necessary for so many metabolic imbalances, particularly if you’re trying to compensate vitamin B1 deficiency of vitamin B6 deficiency. Even for B12 deficiency it’s necessary, because vitamin B2 participates in so many intracellular reactions, inside mitochondria.

    This methylated form is required for people wigh MTHFR problems.

    I’m happy to find this clean supplement in the right dose and the right form!

  • DH
    Danielle H.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    Great product!

    They’re always a solid company.

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