Real reviews from real customers.
- Provides 250 mg of S-Adenosyl-L-methionine (SAMe) per 2 vegan capsules
- Supports methylation as the body’s main methyl donor
- Supports healthy mood, liver function, joint comfort, and histamine metabolism
Do you have histamine concerns, mood imbalances, or want to support healthy joints? You may be deficient in your body’s main methyl donor—S-adenosylmethionine—also known as SAMe.†
SAMe by Seeking Health provides 250 mg of S-adenosyl-L-methionine (SAMe) per acid-resistant, vegetarian capsule.
SAMe is a vulnerable nutrient. Many SAMe supplements on the market are unstable. We use acid-resistant capsules designed for optimal delivery of SAMe to the gut for absorption. To further optimize stability and prevent degradation, the capsules are protected from moisture and air in a desiccated bottle.†
SAMe (S-adenosylmethionine or S-adenosyl-L-methionine) is your body's main methyl donor. It is found in nearly every tissue and fluid. It is involved in hundreds of biochemical reactions in the human body. By providing your body methyl groups, SAMe plays vital roles in DNA expression, neurotransmitter and hormone balance, normal liver cell regeneration, and much more.†
SAMe aids in normal cartilage production, playing a major role in joint and bone health. SAMe is also an important part of histamine intolerance protocols. It is a cofactor for the HNMT enzyme which helps to break down histamine for healthy inflammatory responses and mast cell balance.†
SAMe is a nutrient cofactor for many important enzymatic reactions in the body, including the COMT enzyme. COMT helps you break down excess dopamine to support a healthy mood and feelings of calm.†
Because so many compounds and processes in your body depend upon methyl groups, SAMe is known to support many areas of health.†
SAMe by Seeking Health supports healthy:†
Now you can support your mood, methylation, and more with SAMe by Seeking Health.†
Excellent product, acid resistant capsules etc. I use the pulse method with this one. So far so good. ~Amy J.
Methylation is a critical chemical process in the human body. It is responsible for genetic expression, activating folate, metabolizing homocysteine, and many more vital biochemical functions. Methylation involves transferring a tiny molecule called a methyl group (CH3) to another molecule. The addition of a methyl group essentially ‘activates’ the receiving molecule by changing its shape. A common example of methylation is the addition of a methyl group to folate. This converts folate into its active form known as 5-MTHF (methylfolate).
The body’s main methyl donor is SAMe (S-adenosylmethionine). SAMe travels around the body, donating methyl groups to molecules in need. Once activated, these molecules can now perform their jobs of keeping our body systems running smoothly. Because so many compounds and processes in your body depend upon methyl groups and methylation, SAMe is known to support many areas of health, including sleep, mood, joints, and histamine sensitivity.†
It is important to realize that 80% of all methylation in the human body is used to make two important compounds: creatine and phosphatidylcholine.†
While 80% of all methylation in the human body is used to make creatine and PC, there are hundreds of other processes that rely on SAMe donating its methyl groups, including DNA expression. The addition of methyl groups tells your DNA how and where to function.†
Methyl groups also bind toxins and excess estrogen. This facilitates their excretion from the body. The addition of methyl groups to N-acetylserotonin produces melatonin. The number of ways that methylation controls your biochemistry is too long to list.
The primary source of methyl groups in your body is SAMe. SAMe is derived from the amino acid methionine. With the help of numerous enzymes and cofactor nutrients (including magnesium, folate, B12, and riboflavin), methionine can be recycled to make SAMe once again. This entire process of methionine becoming SAMe and being recycled back to methionine is often called methylation or the methylation cycle. However, certain conditions, or blocks in the methylation cycle, can reduce the amount of SAMe your body is able to synthesize.†
Many people have genetic variations that slow down their methylation enzymes. Research indicates that over 50% of the population has an MTHFR genetic mutation.Your MTHFR gene and enzymes play a vital role in keeping your methylation cycle running smoothly. Others may be deficient in any one of the cofactor nutrients required to synthesize SAMe. In either case, SAMe production can become diminished.
By supplementing with SAMe, you can support your body’s own production of this critical methyl donor. SAMe by Seeking Health supports the health and function of:†
SAMe by Seeking Health provides 250 mg of S-adenosyl-L-methionine (SAMe) per vegetarian-friendly capsule. To protect this vulnerable nutrient from being destroyed by stomach acid, SAMe has been encapsulated in acid-resistant capsules. The capsules are contained in a desiccated bottle to optimize their stability and prevent degradation from air and moisture. Experience the endless beneficial effects of SAMe today with SAMe capsules by Seeking Health.†
Serving Size: 2 Capsules
Servings Per Container: 30
|SAMe (S-adenosyl-L-methionine)||250 mg||**|
|**Daily Value (DV) not established.|
Other Ingredients: Acid-resistant capsule (hypromellose, gellan gum, and water), microcrystalline cellulose, ascorbyl palmitate, and silica.
Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives
Take two capsules 45 minutes before or 60 minutes after a meal or as recommended by your healthcare provider. Taking away from food increases absorption.†
Children and pregnant, lactating, or breastfeeding women should consult their healthcare professional prior to use. Do not use if tamper seal is damaged. If you are taking any medications for depression or anxiety, click here.
|SAMe (S-adenosyl-L-methionine)||The body’s main methyl donor; Supports healthy mood, connective tissues, glutathione production, liver health, histamine metabolism, and methylation processes|
SAMe is for those seeking healthy methylation support.†
SAMe supports normal neurotransmitter synthesis and hormone metabolism. In turn, this supports feelings of calm and a positive mood.†
Due to its role in histamine breakdown, SAMe is great for those seeking histamine metabolism support.†
SAMe may also support bone and joint health due to its roles in healthy synthesis of connective tissues†
Take one capsule 45 minutes before or 60 minutes after a meal or as recommended by your healthcare professional. Taking away from food increases absorption.†
Dr. Ben Lynch recommends ensuring adequate magnesium levels for an optimal experience with SAMe. Magnesium and SAMe are both cofactors for the COMT enzyme, needed to support normal dopamine breakdown. Those supplementing with SAMe, in particular those with slow COMT gene/enzyme function, may consider adding Optimal Magnesium to your SAMe regiment to support COMT function.†
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Real reviews from real customers.
My recent blood work showed slightly high liver enzymes. In addition, I am dealing with histamine intolerance. I especially appreciate SAMe because it supports both of those.
I can feel healthy strength in my body after taking this. It's like my body feels restored. I would continue to purchase this when the supply runs out.