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DAO Enzyme

Original price $38 - Original price $510
Original price $114
$38
$38.00 - $433.50
Current price $38

Key Benefits:†

Quality DAO Supplement

  • Digests histamine fast using the patented DAOgest® enzyme
  • Eat and drink with confidence again!
  • Supports healthy histamine levels in the small intestines, colon, uterus, bladder, prostate and breast milk.
New Name Histamine Digest is changing to DAO Enzyme, a name that more clearly reflects its role in histamine breakdown.

During the transition, you may receive bottles labeled Histamine Digest or DAO Enzyme. It’s the same trusted, high-quality formula you know and rely on.
Purchase Type
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Third Party Tested

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Free Shipping

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60-day Return Policy

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High End Ingredients

Important Note:

DAO Enzyme is very effective for providing the enzyme immediately to support your digestive system.

DAO Enzyme is known as a palliative supplement. It helps you feel great, but it doesn't solve the underlying problem.

Ultimately, you want your body’s DAO enzyme to function well on its own. It takes time to figure out how to heal your gut, restore your microbiome, and balance your immune system. Work with a naturopathic physician or integrative health professional to help you work through these areas.

It’s possible to experience relief now. Use DAO Enzymeso you can enjoy feeling healthy and comfortable when consuming foods or drinks high in histamine.

Over time, as you work on healing your gut, restoring your healthy microbiome, and balancing your immune system, you’ll likely need less DAO Enzyme to support healthy histamine metabolism.

Change in bowel frequency may occur from using DAO Enzyme .

High amounts of histamine in the gut are associated with loose stools or diarrhea, while low amounts are associated with constipation. Since DAO Enzyme supports healthy histamine levels, taking too much may contribute to harder-to-pass stools.

If stools become harder to pass, only use DAO Enzyme when eating foods or drinks with histamine.

If you continue having harder-to-pass stools, then stop using DAO Enzyme and consume a histamine-containing drink like kombucha. If you can pass stools normally again, you know you may have taken too much DAO Enzyme. Adjust your use as needed.

Note that your use of DAO Enzyme will reduce as you restore a healthy gut lining and microbiome.

This is why it’s highly recommended to use ProBiota HistaminX in conjunction with DAO Enzyme each evening after dinner. ProBiota HistaminX supports a healthy gut microbiome.

Can’t digest histamine?

DAO Enzyme can do it for you.

Now you can eat and drink with confidence.

If any of the following statements relate to you, DAO Enzyme may help support healthy histamine levels:

  • My gut microbiome is messing with me, and I’ve been told I have a leaky gut.
  • I’m breastfeeding, and I notice my baby experiences colic when my diet consists of histamine-containing foods or drinks.
  • I’m pregnant and experiencing morning sickness and vomiting.
  • My histamine intolerance was gone when I was pregnant and back postpartum.
  • I need Metformin and want to support a healthy histamine response.
  • Certain probiotics (Streptococcus, L. fermentum, L. casei, and L. bulgaricus) make me feel worse.
  • I need Metformin and want to support a healthy histamine response while taking it.
  • I don’t have food allergies but experience uncomfortable symptoms after consuming foods that are aged, fermented, or cured. The same happens with citrus juices and overly ripe fruit.
  • I have a dirty DAO gene
  • SIBO is troubling me and I believe it’s contributing to my histamine intolerance. I’d like to support healthy histamine levels.
  • After consuming high-histamine foods or drinks, I experience symptoms such as headaches, skin issues, tiredness, sleep problems, stomach discomfort, bladder issues, heart palpitations, and sneezing.

Alternatively, consider Histamine Nutrients or ProBiota HistaminX.

Key Ingredients

Inside the Uncompromising Quality of Our Ingredients

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  • DAOgest® (Diamine oxidase)
    This patented enzyme, derived from porcine (pork) kidney extract, supports the healthy breakdown of histamine in many areas of your body —especially the small intestine, colon, placenta, kidney, appendix, testis, and prostate.

DAOgest® is a trademark licensed by BIOIBERICA, S.A.U

When taken with meals, DAO Enzyme helps break down histamine found in foods and drinks. Histamine will be at a healthy level, which will help eliminate feelings related to histamine intolerance.†‡

When taken on an empty stomach, DAO Enzyme helps break down histamine produced by the microbiome or your gut’s immune system.

This is a great idea to try: Take 1 capsule of DAO Enzyme on an empty stomach to see if you feel better within 30 minutes.

Why would this be useful? High amounts of histamine are produced by an unhealthy microbiome or an overactive gut immune system.

If you feel better, continue using DAO Enzyme on an empty stomach as needed. DAO Enzyme supports a healthy histamine balance in the gut.

DAO Enzyme may support healthy levels of histamine within the small intestine, colon, kidneys, uterus, appendix, placenta, prostate, or testicles. This is very important as unhealthy levels of histamine within these areas contribute to problems locally or throughout the body.

Children 4 years of age and older may use DAO Enzyme. If they cannot swallow the small capsule, you may need to open it and mix in a bite of applesauce.

Breastfeeding women may use DAO Enzyme. Histamine gets absorbed from the gut and into breastmilk. If breastmilk has higher levels of histamine, the breastfeeding baby may experience colic. Infant colic is associated with higher levels of histamine. Support healthy levels of histamine in your breastmilk by taking DAO Enzyme.

Pregnant women may use DAO Enzyme if approved by a healthcare professional.

Occasional nausea and vomiting during pregnancy is associated with high levels of histamine. Levels of histamine in a healthy pregnancy decrease below values found in healthy non-pregnant women. This is because the placenta is designed to produce a lot of the DAO enzyme. However, sometimes, the levels of histamine exceed the ability of the placenta’s DAO enzyme to digest histamine.

In some complications of pregnancy, maternal blood histamine levels rise above those associated with a healthy pregnancy. Many of the complications of pregnancy, including preeclampsia, preterm labor, spontaneous abortion, and hyperemesis gravidarum, are associated with increased levels of maternal blood histamine. Supporting healthy levels of maternal blood histamine levels during pregnancy, especially during such complications, may be helpful.

Suggested Use

As needed, anytime, take 1 capsule before eating or drinking. Alternatively, as needed, take 1 capsule away from food or drink if wanting to support uterine comfort during the menstrual cycle, occasional nausea from pregnancy or healthy histamine levels in your digestive system. Capsules may be opened and sprinkled on a bite of food. Use as directed by your healthcare professional.

Suitable for

Bariatric, methyl-sensitive, pregnancy, breastfeeding, ages 4 and up

NOT Suitable for

Vegetarians, vegans, infants

Delivery Method

Capsules

Age Suitability

Adults, age 4 and up

How to Store

Keep closed in a cool, dry place out of reach by children.

What our customers say

Real reviews from real customers.

4.8
Rated 4.8 out of 5 stars
Based on 791 reviews
Total 5 star reviews: 700 Total 4 star reviews: 59 Total 3 star reviews: 13 Total 2 star reviews: 6 Total 1 star reviews: 13
97%would recommend this product
Reviews Summary
Customers say this supplement helps them enjoy a wider variety of foods more comfortably. Many reviews mention taking it before meals to support their dining experience. Common feedback includes its effectiveness for dining out and social occasions. Users appreciate its role in their daily routines, with several noting they carry it with them regularly. While most report positive experiences, a few mention varying results or concerns about cost. Reviews frequently highlight its value for dietary flexibility and mealtime comfort.
Customers Talked About
Rating
Ratings
791 reviews
  • G
    Grace
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 hours ago
    Seems to work

    Seems to help with higher histamine foods. Great service and delivery.

  • C
    Carolina
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    5 hours ago
    DAO before meals is very helpful

    DAO before meals is very helpful for those with histamine intolerance like me. Easy to take and swallow, no after taste. Of course it's more helpful if you get the other products, but I understand the cost and burden on our pockets. I really wished there was a special discount for people that depend on these products for support, especially during season changes.

  • C
    Cynthia
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    17 hours ago
    Histamine episode go to

    DAO Enzyme is my go to when a histamine episode begins. I will take two or three and drink a hydration pack and usually with in 30 minutes, my histamine begins to calm down.

    I panic when I get down to half a bottle. I make sure I have some with me every where I go.