L-Methylfolate Supplements
L-methylfolate is the most abundant form of folate in your body. It is also referred to as active folate or L-5-MTHF. Other types of folate need to be converted into active forms. People with MTHFR gene variants may not be able to activate folic acid. If you are low on this critical nutrient, your methylation cycle won’t work effectively.
Methylation is essential for regulating gene expression and controlling how your DNA works. L-methylfolate supports healthy red blood cells, mental health, and normal homocysteine levels.
L-methylfolate is the most abundant form of folate in your body. It is also referred to as active folate or L-5-MTHF. Other types of folate need to be converted into active forms. People with MTHFR gene variants may not be able to activate folic acid. If you are low on this critical nutrient, your methylation cycle won’t work effectively.
Methylation is essential for regulating gene expression and controlling how your DNA works. L-methylfolate supports healthy red blood cells, mental health, and normal homocysteine levels. It is found in foods like leafy greens and liver. If you aren’t eating a lot of these, you may benefit from a dietary supplement to support healthy folate levels.†
Seeking Health’s L-methylfolate supplements include L-5-MTHF and Active B12 with L-5-MTHF. You can also get Optimal Prenatal and Optimal Multivitamin, which provide folate along with active vitamin B12 (methylcobalamin), calcium, and other important vitamins and minerals.
Check out this Folate Comparison Chart to select the right folate for you.
Explore L-methylfolate supplementation options below.
If you find that methylated supplements make you feel jittery or upset, use this comparison chart to learn about the differences between methylated and non-methylated products or check out this article.
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Best SellerActive B12 with L-5-MTHF - 60 Lozenges
4.9Rated 4.9 out of 5496 Reviews Based on 496 reviewsFrom $21.95Active B12 with L-5-MTHF Lozenges by Seeking Health provide 1,360 mcg DFE (800 mcg) of pure non-racemic L-methylfolate in an easy-to deliver lozeng...
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Best SellerHomocysteX Plus - 60 Capsules
4.9Rated 4.9 out of 5191 Reviews Based on 191 reviewsFrom $32.95HomocysteX Plus by Seeking Health supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TM...
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Best SellerBonus RewardsB Complex Plus - 100 Capsules
4.9Rated 4.9 out of 5249 Reviews Based on 249 reviewsFrom $27.95B Complex Plus by Seeking Health provides eight B vitamins with active forms of folate, vitamin B12, riboflavin, and B6. This complex also contains...
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Claire C.

Awesome
Keeps me hydrated so I can avoid breaking my fast until lunch time! I love the fizziness of the seltzer flavor.

Cheryl

Best probiotic for women
I love this probiotic. I often get flora imbalances since having my third child. I have been using this for 4 months a few times per week, and have had no issues since.