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Hydroxo-Adeno B12

  • Methyl-free forms of vitamin B12
  • Powerful energy and detoxification support
  • Supports healthy methylation and homocysteine levels

Who Needs Hydroxo-Adeno B12

Do you experience digestive issues? Poor digestion can lead to B12 deficiency. Have you been struggling with low energy or mood? B12 plays critical roles in creating energy and important mood neurotransmitters. Are you sensitive to methylated nutrients but want to support healthy methylation in your body?

You may need a methyl-free form of vitamin B12.

Hydroxo-Adeno B12 contains 2,000 mcg of methyl-free B12 in a well-digested lozenge. The bioavailable forms of adenosylcobalamin and hydroxocobalamin support optimal vitamin B12 levels in your body.

Hydroxo-Adeno B12 supports healthy detoxification and energy in one B12 supplement.

Hydroxocobalamin (Hydroxo B12) supports the normal detoxification of toxins present in environmental exposures, such as smoke inhalation and other pollutants.

Adenosylcobalamin (Adeno B12) is present in the mitochondria to support ATP (energy) production.

Some people experience side effects from methylated nutrients. These can include nervousness, headaches, or rapid heartbeat after taking methylcobalamin or methylfolate.

Hydroxo-Adeno B12 provides vitamin B12 in the non-methyl forms of hydroxo B12 and adeno B12. These methyl-free forms take a few additional enzyme steps before the methyl groups are liberated for your body to use. This slower delivery can provide relief and comfort in those sensitive to methylated nutrients.

You shouldn’t be struggling with side effects related to your supplements. Now, you can provide your body the B12 support it needs...without the headache of methyl donors!

Customer Review

A Great Product At A Great Price

My doctor highly recommends Hydrox-Adeno B12 lozenges, and I do, too! This is a great product. I make sure I use it every day to help me maintain good B12 absorption. The lozenges are easy to take, and they have a pleasant taste. This is a WinWin product for me! ~Margie G.

Key Ingredients In Hydroxo-Adeno B12

  • Hydroxocobalamin: A non-methylated form of B12 that readily converts to methyl B12 in the body. Supports energy production and helps your body utilize folate for methylation processes. Plays a unique role in maintaining healthy detoxification pathways.
  • Adenosylcobalamin: A non-methylated form of B12. Large concentrations are found naturally in the cell’s mitochondria, where it plays roles in energy production. Supports healthy methylation processes by providing adequate cobalamin for the MTR enzyme.

Why Hydroxo-Adeno B12 Works

Hydroxo-Adeno B12 contains B12 in non-methylated, active forms.

Hydroxocobalamin is the most stable form of vitamin B12. It appears to circulate longer in the human body than all other forms. ‘Hydroxo’ B12 can easily convert to both ‘adeno’ and ‘methyl’ forms to support healthy methylation and energy production. It also supports the normal detoxification of toxins present in environmental exposures, such as smoke inhalation and other pollutants.

Adenosylcobalamin is present in the mitochondria of your cells to support energy production. It is used as a coenzyme to create ATP from cholesterol, branched-chain amino acids, odd chain fatty acids, and propionate.

These methyl-free forms are readily transformed into cobalamin that enters the cell’s cobalamin pool. When needed, cobalamin is pulled from this pool to use in various processes, including methylation.

Cobalamin plays essential roles in the methylation cycle to support healthy homocysteine breakdown. Cardiovascular and general wellness are dependent on maintaining homocysteine levels in a healthy range.

Your body needs both vitamin B12 and methylfolate (5-MTHF) to metabolize homocysteine into methionine via the MTR enzyme. From methionine, SAMe is created, your body’s main methyl donor. SAMe donates methyl groups to support your body’s methylation processes, including DNA expression.

Without adequate B12, your body cannot effectively utilize methylfolate through the MTR enzyme. By consuming Hydrox-Adeno B12, you give your body indirect methylation support without the side effects some people experience from methyl groups.

Because B12 needs folate to support proper methylation, be sure to pair Hydrox-Adeno B12 with a bioactive form of folate, such as methyl-free Folinic Acid.

It’s never been easier to get your daily B12. One tasty Hydrox-Adeno B12 lozenge supports optimal vitamin B12 levels without the headache of methyl donors!

Hydroxo-Adeno B12
Supplement Facts

Serving Size: 1 Lozenge
Servings Per Container: 60

Vitamin B12 (as hydroxocobalamin and adenoslycobalamin) 2,000 mcg 83,333%
DV = Daily Value

Other Ingredients: Xylitol, natural cherry flavor, ascorbyl palmitate, malic acid, and silica.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Lozenges
  • How To Store: Keep closed in a cool, dry place out of reach by children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, and Wheat

How to Use Hydroxo-Adeno B12

Suggested Use

Initial use for the first week, take ½ a lozenge by mouth, let dissolve slowly, then swallow. If needing more support, increase to 1 full lozenge. Take as needed. Do not take within 5 hours of bedtime as it may interfere with sleep. Use as directed by your healthcare professional.


Consult with your healthcare practitioner prior to use. Do not use if tamper seal is damaged.

FAQs for Hydroxo-Adeno B12

What is the purpose of each ingredient in Hydrox-Adeno B12?

Ingredients Purpose
Vitamin B12 (as hydroxocobalamin and adenosylcobalamin) Supports cellular and cognitive health, healthy amino acid and fatty acid metabolism, healthy detoxification pathways, and healthy energy levels

Who is Hydrox-Adeno B12 intended for?

Hydrox-Adeno B12 is intended for those seeking a blend of both non-methylated forms of vitamin B12 (an alternative to methylcobalamin) in a lozenge format designed for optimal digestion, absorption, and utilization.

Hydrox-Adeno B12 is great for those looking for the healthy detoxification benefits of hydroxocobalamin, and the energy-supporting benefits of adenosylcobalamin. Both of these vitamin B12 forms support natural methylation processes without the side effects of methyl donors.

Hydrox-Adeno B12 is gluten-free.

Which vitamin B12 supplement is right for me?

Click here to view our Vitamin B12 Supplement Comparison Chart.

This article will help you determine if you need a methyl-free supplement..

If you have a question that's not addressed
here, see all frequently asked questions.


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What our customers say

Real reviews from real customers.

Rated 4.9 out of 5 stars
Based on 123 reviews
Total 5 star reviews: 113 Total 4 star reviews: 8 Total 3 star reviews: 1 Total 2 star reviews: 0 Total 1 star reviews: 1
99%would recommend this product
123 reviews
  • MF
    Melanie F.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    Great supplement

    I love this supplement, it’s easy to take and I notice when I e forgotten!

  • KF
    Karen F.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    Perfect amount of B-12

    I like that this comes in an easy to dissolve tablet. This is the amount of B-12 that I need.

  • KS
    Kimberly S.
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago

    We are always looking for easier ways for our daughter to get her vitamin and mineral needs without her having to swallow a pill. Not only does she love the taste, but she looks forward to taking it! We have seen HUGE improvements with this supplement with get COMT . Highly recommend!

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