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L-5-MTHF - 8,500 mcg DFE (5,000 mcg/5 mg)
- Supports healthy neurotransmitter formation
- Supports healthy cognition and mood
- Supports healthy genetic expression
Methylation controls multiple biochemical pathways in your body.
Your genetics, heart health, hormones, sleep, stress, mood, and detoxification depend on healthy methylation.
Where does your body get the methyl groups needed to carry out methylation? Primarily from folates that come from food and intestinal microbes. Food folates must be first converted into an active form before your body can use them.†
Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).†
Over 50 percent of the population is thought to have a genetic mutation in their MTHFR gene. Thus, they may not be achieving adequate methylfolate levels from food alone.†
Because L-5-MTHF bypasses the MTHFR enzyme, it can provide methylation support for those with MTHFR polymorphisms.†
Folate (as bioavailable L-5-MTHF) is:†
Seeking Health’s L-5-MTHF contains 8,500 mcg DFE of methylfolate in the bioavailable form of L-5-methyltetrahydrofolate (L-5-MTHF).†
The bioactive form of L-methylfolate (L-5-MTHF) is well-utilized in the methylation cycle. It is often the preferred form for those with methylation, homocysteine, or MTHFR gene mutation concerns.†
Mutations in your MTHFR gene can lead to reduced L-methylfolate production and a less functional methylation cycle. Challenges in the methylation cycle are associated with an increased risk for cardiovascular and mood issues, birth defects, and infertility concerns.
Mutations in this gene can also slow your body’s ability to convert folate into its active forms. Thus, a large majority of people may benefit from consuming an L-methylfolate dietary supplement.†
The most direct way to support methylation and MTHFR genetic mutations is with L-methylfolate (L-5-MTHF).†
Scientific research has demonstrated that higher strengths of L-5-MTHF may also support healthy neurotransmitter formation. A key cofactor is needed for both serotonin and dopamine metabolism. It is called BH4 or tetrahydrobiopterin. It appears that L-5-MTHF may help to both make more BH4 and also regenerate BH4 that has been previously used to make neurotransmitters. By doing so, L-5-MTHF plays an important role in assuring normal neurotransmitter formation takes place.†
Supplementing with bioavailable L-5-MTHF supports:†
Our 8,500 mcg L-5-MTHF is ideal for those clients who have consulted a healthcare practitioner and have been informed that they may benefit from additional support with their methylation and neurotransmitter pathways. If you or your practitioner are concerned with getting too many methyl groups when taking a higher dose of L-5-MTHF, chemistry shows that the ingestion of higher levels of both glycine (an amino acid found in collagen) and niacin may support normal levels of methylation reactions.†
Get ready for your methylation cycle to fire on all cylinders with Seeking Health’s L-5-MTHF!†
Folate plays critical roles in methylation. By donating its methyl groups, folate regulates DNA expression and much more. Without sufficient bioavailable folate, your cells cannot effectively express your genes.†
The MTHFR gene converts food folates into methyl folates. However, MTHFR variations and environmental or lifestyle stress can slow this gene down. If the MTHFR gene is slowed, MTHFR enzyme function is also slowed. The result can be a debilitating folate deficiency.
The artificial version of folate, folic acid, is often prescribed to folate-deficient individuals. Supplementation with L-5-MTHF may be more effective than folic acid supplementation at increasing blood folate levels.†
Folic acid is never included in any of our Seeking Health dietary supplements. This artificial version of folate is not well-utilized by the body and can produce adverse effects. Folic acid must go through several enzymatic steps before it is converted into usable methylfolate. Its inefficient chemical structure may even slow down your SLC191A, DHFR, and MTHFR genes to the point of folate deficiency! Folic acid can also block usable folate from entering your cells, further contributing to folate deficiency.†
By supplementing with the natural form of folate as L-5-MTHF, you bypass the MTHFR enzyme. The methylated form, L-5-methylfolate (L-5-MTHF), requires no additional metabolic steps to be used by the body. This is why it is often the preferred choice for those with folate absorption or metabolic defects.†
L-5-MTHF also supports the production of important mood neurotransmitters. These include dopamine, serotonin, melatonin, epinephrine, and norepinephrine. This is how supplementation with L-5-MTHF can help to support a healthy mood.†
Seeking Heath’s L-5-MTHF provides a pure, non-racemic form of L-methylfolate. Each easy-to-take capsule offers a potent dose of 1,700 mcg DFE of folate as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt. This superior form supports healthy methylation, mood, and more.†
Because folate needs B12 to support proper methylation, be sure to pair L-5-MTHF with a bioactive form of B12, such as Active B12 1000.†
Now you can go about your day with confidence, knowing your methylation cycle is firing on all cylinders with L-5-MTHF!†
Serving Size: 1 Capsule
Servings Per Container: 60
|Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt)||8,500 mcg DFE (5000 mcg)||2,125%|
|% DV (Daily Value) based on standard 2,000 calorie daily intake|
|**Daily Value not established|
Other Ingredients: Microcrystalline cellulose, vegetarian capsule (hypromellose and water), ascorbyl palmitate, L-leucine, and silica.
Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives
Take 1 capsule daily, or use as directed by your healthcare provider. Do not take within 5 hours of bedtime as it may interfere with sleep.
Children and pregnant or lactating women should consult their healthcare professional for medical advice prior to use. Do not use if tamper seal is damaged. Consult a healthcare professional prior to use if you are taking any medications or undergoing treatment for any medical condition.†
|Folate (Quatrefolic® 6S)-5-methyltetrahydrofolate, glucosamine salt)||Supports a healthy nervous system, methylation, homocysteine recycling, and prenatal regimen along with a healthy diet and lifestyle|
L-methylfolate (L-5-MTHF) is a superior form of folate that is well-utilized in the body. This is because 80 percent of the human body's folate is in this form.†
L-5-MTHF is the form of folate that is used for methylation. Methylation is simply when one compound donates a methyl group to another compound. By having a methyl group attached, the compound's function changes.†
At higher strength, L-5-MTHF has also been shown to support healthy neurotransmitter metabolism by supporting the BH4 (tetrahydrobiopterin) cofactor used in both the serotonin and dopamine pathways.†
You know when L-methylfolate works because of how you feel. It's typically very fast to notice if it's working or not.†
According to Dr. Ben Lynch, supplementing with L-methylfolate can support healthy:†
In order for L-methylfolate to work, it requires vitamin B12. Reduced oxidative stress is also needed for L-methylfolate to function.†
L-methylfolate needs the following to support methylation:†
Talk to your qualified healthcare practitioner before starting methylfolate supplementation. A trained health professional will be able to determine the appropriate dosing and whether methylfolate is right for you.
Click here to view our Folate Supplement Comparison Chart.
Read this blog: The different forms of folate: which one is right for you?
This blog article explains folic acid side effects.
If you have a question that's not addressed
here, see all frequently asked questions.
Real reviews from real customers.
I’ve been taking these for a long time.
Love this brand. Great quality!
Great value in a higher dose. It has been difficult to find this in a larger dosage, very happy that this is available!